Erythrocyte transport efficacy of human blood: a rheological point of view

Bogár, Lajos; Juricskay, I.; Késmárky, Gábor; Kenyeres, Péter; Tóth, Kálmán

doi:10.1111/j.1365-2362.2005.01562.x

Cited by 21 publications

(26 citation statements)

References 11 publications

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“…Although some hemorheological parameters differed between SCC and SCA patients, both have markedly reduced and essentially identical HVR levels at all shear rates ( Figure 1); our calculated mean HVR values are consistent with the range reported by Serjeant et al 29 Thus the oxygen transport effectiveness of blood in SCA and SCC subjects is lower than in controls, a finding also seen in other disease states. 6 Recent results obtained by Alexy et al 8 also support our findings. They investigated HVR in mixtures of AA and SCA RBC and found that HVR decreased as the proportion of HbS increased; due to the non-Newtonian, shear-thinning flow behavior of blood, HVR also decreased as shear rate decreased.…”

Section: Discussionsupporting

confidence: 82%

“…1,4 For example, increased RBC aggregation, elevated blood viscosity and the ratio of hematocrit (Hct) to blood viscosity (HVR, an index to the oxygen transport potential of blood) have been shown to significantly affect in vivo microcirculatory flow dynamics. [5][6][7] In a recent study, Alexy et al described impaired HVR in patients with SCA and suggest that the reduced HVR might play a role in the pathophysiology of the disease. 8 Unfortunately, similar studies are lacking for patients with SCC and sickle cell trait (AS).…”

Section: Introductionmentioning

confidence: 99%

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Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease

Tripette¹,

Alexy²,

et al. 2009

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BackgroundRecent evidence suggests that red blood cell aggregation and the ratio of hematocrit to blood viscosity (HVR), an index of the oxygen transport potential of blood, might considerably modulate blood flow dynamics in the microcirculation. It thus seems likely that these factors could play a role in sickle cell disease. Design and MethodsWe compared red blood cell aggregation characteristics, blood viscosity and HVR at different shear rates between sickle cell anemia and sickle cell hemoglobin C disease (SCC) patients, sickle cell trait carriers (AS) and control individuals (AA). ResultsBlood viscosity determined at high shear rate was lower in sickle cell anemia (n=21) than in AA (n=52), AS (n=33) or SCC (n=21), and was markedly increased in both SCC and AS. Despite differences in blood viscosity, both sickle cell anemia and SCC had similar low HVR values compared to both AA and AS. Sickle cell anemia (n=21) and SCC (n=19) subjects had a lower red blood cell aggregation index and longer time for red blood cell aggregates formation than AA (n=16) and AS (n=15), and a 2 to 3 fold greater shear rate required to disperse red blood cell aggregates. ConclusionsThe low HVR levels found in sickle cell anemia and SCC indicates a comparable low oxygen transport potential of blood in both genotypes. Red blood cell aggregation properties are likely to be involved in the pathophysiology of sickle cell disease: the increased shear forces needed to disperse red blood cell aggregates may disturb blood flow, especially at the microcirculatory level, since red blood cell are only able to pass through narrow capillaries as single cells rather than as aggregates.Key words: sickle cell disease, red blood cell aggregation, viscosity, red blood cell deformability. Citation: Tripette J, Alexy T, Hardy-Dessources M-D, Mougeneld D, Beltan E, Chalabi T, Chout

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease

Tripette¹,

Alexy²,

et al. 2009

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“…This is in essence expressed through the theoretical "optimal HCT". Nemeth et al (2009) report a range around a HCT of 45% to be optimal in dogs at shear rates of 90 s -1 and 200 s -1 , and Bogar et al (2005) report a range of about 43% at a low shear rate (10 s -1 ) and 60% at a high shear rate (200 s -1 ) in healthy human volunteers. WBV is known to influence tissue perfusion through increased venous resistance Baskurt et al, 1999;Cabel et al, 1997;Yalcin et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…In the camels studied the theoretical "optimal HCT" varied with the shear rates measured, as in other species (Bogar et al, 2005;Nemeth et al, 2009). At high shear rates above 100 s -1 , where the rheological characteristics of blood change and generally resemble a more Newtonian behaviour (e.g.…”

Section: Discussionmentioning

confidence: 99%

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Towards a basic understanding of the properties of camel blood in response to exercise

Auer

Gleiß

Windberger

2015

Emir. J. Food Agric

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The objective of the study was to investigate changes in blood fluidity in camels in response to exercise. 11 camels (9 male, 2 female) performed a 30 minutes run. Blood lactate changes indicated mild aerobic exercise. HCT and PCV remained essentially unchanged while plasma protein concentration decreased mildly suggesting a gain in blood volume of 1-2 L. Whole blood viscosity (WBV) did not change significantly at any shear rate (flow curves at logarithmic shear rate (SR) ramp, 37°C:11.6-500 s -1 ), and viscosity ratio (WBV 500s -1 / WBV 11.6s -1 ) was maintained as well. RBC aggregation indices M0 and M1 did not change significantly either. The theoretical optimal HCT, i.e. the range of the HCT at which the O 2 -transport capacity (HCT/WBV) is highest, was estimated by measuring WBV of RBC dilutions in autologous plasma. The RBC concentrations were measured as PCV and thus PCV/WBV plotted against PCV (2nd degree polynom). At 11.6 s -1 the "optimal HCT" was at a PCV of 49.2%, and decreased to 34.8% at 500 s -1 . In arteries and arterioles (high SR), the actual PCV observed may be regarded "optimal", whereas in venules and veins (low SR), the actual PCV observed was lower than its theoretical "optimal" value. This indicates that a possible increase in PCV might provide a sizable reserve in performance capacity. During a more strenuous exercise or at arid environments this would optimize O 2 transport at low shear areas by eventually preventing blood from becoming sluggish.

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Hemodilution on microvascular oxygen delivery potential of the blood during coronary bypass surgery

et al. 2022

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Erythrocyte transport efficacy of human blood: a rheological point of view

Abstract: This is one of the first reports in which a theoretically optimal haematocrit value was determined using the haematocrit/blood viscosity ratio. Further studies are needed to examine the potential clinical usefulness of this approach.

Cited by 21 publications

References 11 publications

Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease

Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease

Towards a basic understanding of the properties of camel blood in response to exercise

Hemodilution on microvascular oxygen delivery potential of the blood during coronary bypass surgery

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