Erythrocyte Transport Function in Cystic Fibrosis

Feig, Stephen A.; Segel, George B.; Kern, Kenneth A.; Osher, Alan B; Schwartz, Robert H.

doi:10.1203/00006450-197405000-00008

Cited by 16 publications

(6 citation statements)

References 4 publications

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“…Grinwald and Segal (12) found ouabain-insensitive Na emux diminished in cystic fibrosis erythrocytes for 35%. These findings could not be confirmed by Feig et al (7) and Horton er al. ( 13) who found no abnormalities in the active Na and K transport in cystic fibrosis red blood cells.…”

Section: Discussioncontrasting

confidence: 56%

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Anion Transport and 2,3-Diphosphoglycerate in Cystic Fibrosis Red Blood Cells

Berghout

Bender

1984

Pediatr Res

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Section: Discussioncontrasting

confidence: 56%

“…Furthermore, where divalent cation transport in the cystic fibrosis red blood cell is concerned, a normal Ca-ATPase activity was observed by Feig et al (7) and McEvoy ef al. (23).…”

Section: Discussionmentioning

confidence: 72%

Anion Transport and 2,3-Diphosphoglycerate in Cystic Fibrosis Red Blood Cells

Berghout

Bender

1984

Pediatr Res

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“…Our finding of a marginally significant decrease in the pancreatic insufficient subpopulation probably reflects technical and perhaps patient population differences from these studies. Previous reports on Ca-ATPase activities in CF erythrocyte membranes other than that of Foder et al (18) did not report attempts to compare the observed activities with any criteria of patient clinical status (1,7,16,24,(27)(28)(29)(30)35). In contrast to our findings of differences based on exocrine pancreatic status, we failed to observe any correlation of Ca-ATPase activities with either general clinical status as documented by a standard fourpart clinical scoring system (10,43) or acute clinical status as judged by the need for hospitalization for intensive pulmonary therapy versus comparatively healthy outpatients.…”

Section: Discussionmentioning

confidence: 94%

“…While Balfe et al (2) found the activities of ouabain-sensitive ATPase of CF erythrocyte membranes to be decreased by about 30%, subsequent investigators (7,16,22,27,32,35) have observed that any decreased (Na + K)-ATPase activities are not significantly different from control activities. Our finding of a marginally significant decrease in the pancreatic insufficient subpopulation probably reflects technical and perhaps patient population differences from these studies.…”

Section: Discussionmentioning

confidence: 99%

Calcium-ATPase Activity in Cystic Fibrosis Erythrocyte Membranes: Decreased Activity in Patients with Pancreatic Insufficiency

et al. 1984

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Summary modulin, of the pancreatic sufficient patients (34.3 f 4.2 and 75.9 f 6.9 nmol/min/mg) was indistinguishable from that of The activity of Ca-ATPase (Ca2+,Mg2+-ATPase, ATP phos-controls (35.8 2.6 and 84.3 f 4.7 nmol/min/mg), while both phohydrolase, EC 3.6.1.3) was measured in erythrocyte mem-activities of patients with pancreatic insufficiency were signifibrane preparations from 37 cystic fibrosis patients, 27 with cantly decreased (28.9 + 1.3, < 0.02; 65.2 + 3.0, < 0.001) pancreatic insufficiency and 10 with pancreatic sufficiency, and to the control group. Similarly, the mean erythrocyte from 24 healthy controls. The mean maximal calcium-stimulated membrane (Na + K)ATPase activity was decreased only for specific activities, in the absence and presence of purified cal-those patients with a history of steatorrhea and who clinically Received August 18, 1983; accepted March 12, 1984. required pancreatic enzyme therapy and had low immunoreactive

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“…Feig et al (13) assayed (Na+-Kf)-ATPase in CF erythrocytes, and Quissell and Pitot (19) assayed ouabain-binding sites in CF fibroblasts, but neither study demonstrated differences compared to their control data. Cole and Sella (7), however, showed that CF saliva inhibited erthrocyte (Na+-K+)-ATPase activity.…”

Section: Discussionmentioning

confidence: 99%

Short Communication: Cystic Fibrosis “Factor(s)” Present Also in Sera of Shwachman's Pancreatic Insufficiency

et al. 1981

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Summarvprotracted diarrhoea of undetermined cause) aged 6 months to 7Using an in vivo closed-loop technique in rat jejunum, we have confirmed previous in vitro studies that cystic fibrosis (CF) serum inhibits water, sodium, and glucose absorption and transmural potential difference. CF heterozygote serum or sera from children with diarrhoeal disorders not associated with exocrine pancreatic insufficiency had no effect on transport. Sera from patients with Shwachman's syndrome and exocrine pancreatic insufficiency had identical effects to CF serum. These results challenge the specificity of the CF "factor." Speculation PANCREATIC-RELATED FACTORSThe pancreas may modulate small intestinal absorption of water, electrolytes, and glucose via an humoral pathway. In exocrine pancreatic insufficiency, there could. be a deficiency of a normal serum factor which stimulates absorption or, alternatively, a factor which inhibits absorption could be present.

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Erythrocyte Transport Function in Cystic Fibrosis

Cited by 16 publications

References 4 publications

Anion Transport and 2,3-Diphosphoglycerate in Cystic Fibrosis Red Blood Cells

Anion Transport and 2,3-Diphosphoglycerate in Cystic Fibrosis Red Blood Cells

Calcium-ATPase Activity in Cystic Fibrosis Erythrocyte Membranes: Decreased Activity in Patients with Pancreatic Insufficiency

Short Communication: Cystic Fibrosis “Factor(s)” Present Also in Sera of Shwachman's Pancreatic Insufficiency

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