Erythrocyte α-linolenic acid is associated with the risk for mild dementia in Korean elderly

Kim, Malgeunsinae; Nam, Jung Hyun; Oh, Dong Hoon; Park, Yongsoon

doi:10.1016/j.nutres.2010.10.005

Cited by 23 publications

(24 citation statements)

References 29 publications

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“…Finally, 21 eligible articles that reported 4438 cases (263 cases of MCI, 320 cases of cognitive decline, 1864 cases of dementia, 1332 cases of AD, and 659 cases of PD) in 181,580 participants from 17 independent cohorts were included (9-13, 24, 44-58). Of these articles, 4 case-control studies were included (50,(53)(54)(55). Table 1 and Supplemental Table 1 show the characteristics of included studies.…”

Section: Methodsmentioning

confidence: 99%

“…Of these studies, 6 trials reported the association between fish consumption and various risk of adverse cognitive outcomes (9-13, 55), 11 trials described the correlation between total PUFAs and risk of adverse cognitive outcomes (24, 44-48, 50, 52, 55-57), 12 trials investigated the association between n-3 PUFAs and risk of adverse cognitive outcomes (11, 24, 44-46, 48-51, 54-56), and 13 trials described the correlation between representative n-3 PUFAs (ALA, EPA, and DHA) and risk of adverse cognitive outcomes (11,12,24,44,45,48,50,51,(53)(54)(55)(56)58). Overall, 7 studies were from the United States (11,13,24,44,53,55,58), 11 studies were from Europe (9, 10, 12, 45-49, 52, 56, 57), 2 studies were from Asia (50,54), and one study was from Canada (51). One study only included men (49), and the other studies included both men and women.…”

Section: Methodsmentioning

confidence: 99%

“…Total PUFA and n-3 PUFA intakes and risk of adverse cognitive outcomes Eleven studies investigated the association between total PUFA intake and MCI (47,55,57), cognitive decline (44,48), dementia (46,50,52,56), AD (46,52), or PD (24, 45) with 156,582 participants and 1474 cases. Two studies investigated both dementia and AD events (46,52).…”

Section: Fish Consumption and Risk Of Adverse Cognitive Outcomesmentioning

confidence: 99%

“…AD, Alzheimer disease; ID, identifier; MCI, mild cognitive impairment; PD, Parkinson disease. association between n-3 PUFA intake and MCI (55), cognitive decline (44,48,49), dementia (46,50,51,56), AD (11,46,51), and PD (24,45,54) Figure 3). For concentrations in blood, the dose-response relation between increments of n-3 PUFA concentrations and lower risks of cognitive decline (RR: 1.03; 95% CI: 0.96, 1.11) or dementia (RR: 0.99; 95% CI: 0.94, 1.04) did not seem significant (Supplemental Figure 4).…”

Section: Figurementioning

confidence: 99%

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Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies

Zhang

Chen

Qiu³

et al. 2016

The American Journal of Clinical Nutrition

272

183

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Background: The intake of fish and polyunsaturated fatty acids (PUFAs) may benefit cognitive function. However, optimal intake recommendations for protection are unknown. Objective: We systematically investigated associations between fish and PUFA intake and mild-to-severe cognitive impairment risk. Design: Studies that reported risk estimates for mild cognitive impairment (MCI), cognitive decline, dementia, Alzheimer disease (AD), or Parkinson disease (PD) from fish, total PUFAs, total n-3 (v-3) PUFAs, or at least one n-3 PUFA were included. Study characteristics and outcomes were extracted. The pooled RR was estimated with the use of a random-effects model metaanalysis. A dose-response analysis was conducted with the use of the 2-stage generalized least-squares trend program. Results: We included 21 studies (181,580 participants) with 4438 cases identified during follow-up periods (2.1-21 y). A 1-serving/wk increment of dietary fish was associated with lower risks of dementia (RR: 0.95; 95% CI: 0.90, 0.99; P = 0.042, I 2 = 63.4%) and AD (RR: 0.93; 95% CI: 0.90, 0.95; P = 0.003, I 2 = 74.8%). Pooled RRs of MCI and PD were 0.71 (95% CI: 0.59, 0.82; P = 0.733, I 2 = 0%) and 0.90 (95% CI: 0.80, 0.99; P = 0.221, I 2 = 33.7%), respectively, for an 8-g/d increment of PUFA intake. As an important source of marine n-3 PUFAs, a 0.1-g/d increment of dietary docosahexaenoic acid (DHA) intake was associated with lower risks of dementia (RR: 0.86; 95% CI: 0.76, 0.96; P , 0.001, I 2 = 92.7%) and AD (RR: 0.63; 95% CI: 0.51, 0.76; P , 0.001, I 2 = 94.5%). Significant curvilinear relations between fish consumption and risk of AD and between total PUFAs and risk of MCI (both P-nonlinearity , 0.001) were observed. Conclusions: Fishery products are recommended as dietary sources and are associated with lower risk of cognitive impairment. Marinederived DHA was associated with lower risk of dementia and AD but without a linear dose-response relation.Am J Clin Nutr 2016;103:330-40.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Fish Consumption and Risk Of Adverse Cognitive Outcomesmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies

Zhang

Chen

Qiu³

et al. 2016

The American Journal of Clinical Nutrition

272

183

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“…In addition, they are associated with reduced cognitive decline during aging [4]. Brain tissue membranes are rich in n -3 PUFAs, which have anti-inflammatory, antioxidant, antiatherogenic, antiamyloid and neuroprotective properties [11]. n -3 PUFAs have also been associated with cardiovascular benefits, because they prevent cardiac arrhythmia, inhibit hepatic triglyceride synthesis, reduce platelet aggregation and, by modifying eicosanoid function, cause vascular relaxation and reduce inflammation [6,12].…”

Section: Introductionmentioning

confidence: 99%

Fatty Acid Status and Its Relationship to Cognitive Decline and Homocysteine Levels in the Elderly

et al. 2014

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Polyunsaturated fatty acids (PUFAs), especially the n-3 series, are known for their protective effects. Considering that cardiovascular diseases are risk factors for dementia, which is common at aging, the aim of this study was to evaluate whether fatty acid status in the elderly was associated with cognitive function and cardiovascular risk. Forty-five elderly persons (age ≥60 years) were included and divided into two groups based on their Mini-Mental Status Examination score adjusted for educational level: the case group (n = 12) and the control group (n = 33). Serum fatty acid composition, homocysteine (Hcy), hs-CRP, lipid profile and different cognitive domains were evaluated. The case group, characterized by reduced cognitive performance, showed higher levels of 14:0, 16:0, 16:1n-7 fatty acids and lower levels of 22:0, 24:1n-9, 22:6n-3 (DHA) and total PUFAs compared to the control group (p < 0.05). The n-6/n-3 ratio was elevated in both study groups, whereas alterations in Hcy, hs-CRP and lipid profile were observed in the case group. Cognitive function was positively associated with the 24:1n-9, DHA and total n-3 PUFAs, while 14:0, 16:0 and 16:1n-7 fatty acids, the n-6/n-3 ratio and Hcy were inversely associated. In addition, n-3 PUFAs, particularly DHA, were inversely associated with cardiovascular risk, assessed by Hcy levels in the elderly.

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Beneficial Effects of Flaxseed Oil (n-3 Fatty Acids) on Neurological Disorders

Farooqui

2012

Phytochemicals, Signal Transduction, and Neurological Disorders

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Erythrocyte α-linolenic acid is associated with the risk for mild dementia in Korean elderly

Cited by 23 publications

References 29 publications

Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies

Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies

Fatty Acid Status and Its Relationship to Cognitive Decline and Homocysteine Levels in the Elderly

Beneficial Effects of Flaxseed Oil (n-3 Fatty Acids) on Neurological Disorders

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