Erythrocytes from patients with myeloproliferative neoplasms and splanchnic venous thrombosis show greater expression of Lu/BCAM

Abstract

Patients with MPN have increased expression of the red cell Lu/BCAM adhesion molecule. Further work is required to determine the role of the increased Lu/BCAM adhesion to the endothelium in the development of thrombosis in MPN of all genotypes.

Dimerization and phosphorylation of Lutheran/basal cell adhesion molecule are critical for its function in cell migration on laminin

“…Lu/BCAM binds to ␣5 chaincontaining laminins and is the unique laminin receptor on the surface of circulating RBCs in humans (1)(2)(3). The adhesive function of Lu/BCAM has been studied mainly in the context of blood and lysosomal pathologies (4), such as sickle cell disease (5)(6)(7)(8)(9), hereditary spherocytosis (10), myeloproliferative neoplasms (11)(12)(13), and Gaucher disease (14), and to a lesser extent in epithelial cells and tumor invasion or metastasis.…”