Erythrocythemia and Neoplastic Tumors

Donati, Robert M.; McCarthy, John; Lange, Robert D.; Gallagher, Neil I.

doi:10.7326/0003-4819-58-1-47

Cited by 68 publications

(10 citation statements)

References 47 publications

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“…[2][3][4][5][6][7] The association of the three has been recorded once by Schonfeld et al 8 The additional findings of hypercalcemia in the current case of hepatoma is a previously unreported association.…”

mentioning

confidence: 77%

Hepatoma Associated with Hypoglycemia, Polycythemia, and Hypercalcemia

Becker¹,

Sternberg²,

Kaiser³

1963

JAMA

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mentioning

confidence: 77%

Hepatoma Associated with Hypoglycemia, Polycythemia, and Hypercalcemia

Becker¹,

Sternberg²,

Kaiser³

1963

JAMA

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“…18 It is also well recognized that hepatocellular carcinoma may lead to erythrocytosis through increased erythropoietin production. [19][20][21][22][23] Conflicting data exist regarding serum erythropoietin level and its response to anemia in humans with liver disease. Two studies found elevated erythropoietin levels in patients with liver disease and anemia.…”

Section: Discussionmentioning

confidence: 99%

Erythropoietin response to post–liver transplantation anemia

et al. 2000

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Anemia frequently accompanies end-stage liver disease. Erythropoietin has recently been shown to be of benefit in a number of diseases complicated by anemia. We studied erythropoietin levels before and after orthotopic liver transplantation (OLT) and correlated these with the degree of anemia. Twenty-seven patients with end-stage cirrhosis who underwent OLT had preoperative and weekly postoperative serum erythropoietin levels determined by a highly sensitive radioimmunoassay. The relation of erythropoietin level to the values for hematocrit, serum creatinine, and cyclosporine and other biochemical test results was evaluated. Before transplantation, 23 patients were anemic; erythropoietin levels were appropriately elevated (72.7 ؎ 37 mU/mL; normal, 10 to 15 mU/mL) for the degree of anemia (hematocrit, 33.1% ؎ 1%) in 16 patients (70%). A blunted erythropoietin response to anemia was found in 7 of the anemic patients with cirrhosis (30%). After OLT, the hematocrit decreased to 29.5% ؎ 0.6% at 4 weeks, with a reciprocal increase in serum erythropoietin levels to 36 ؎ 5 mU/mL. Erythropoietin response appeared appropriate to the degree of anemia in 82% of the liver transplant recipients and blunted in 18%. We conclude that the ability to secrete erythropoietin in response to anemia is defective in many patients with end-stage liver disease, and a normal response may be restored after OLT. The results suggest that exogenous erythropoietin administration may be beneficial in anemic patients with cirrhosis and liver transplant recipients who have inappropriately low serum erythropoietin levels. (Liver Transpl 2000;6: 349-355.)

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“…Neoplasms. Renal cell carcinomas occur with erythrocytosis in 2% of patients [98] and some tumors were demonstrated to retain EPO secretion when cultured in vitro [99,100]. Within the tumor the transcription of mRNA for EPO is confined to epithelial structures and the EPO-producing tumor cells appear therefore not to be derived from cells physiologically producing EPO in the kidney (P. Bruneval, C. Lacombe occurs only in a few patients with renal artery stenosis is most likely due to the simultaneous decline in renal sodium load that usually goes along with the limited blood flow, thus maintaining the balance between renal oxygen supply and oxygen consumption.…”

Section: Autonomous or Inappropriate Increase In Erythropoietinmentioning

confidence: 99%

“…Renal cell carcinomas occur with erythrocytosis in 2% of patients [98] and some tumors were demonstrated to retain EPO secretion when cultured in vitro [99,100]. Within the tumor the transcription of mRNA for EPO is confined to epithelial structures and the EPO-producing tumor cells appear therefore not to be derived from cells physiologically producing EPO in the kidney (P. Bruneval, C. Lacombe, J.L.…”

Section: Autonomous or Inappropriate Increase In Erythropoietinmentioning

confidence: 99%