Erythrocytosis and a fibroid

Yoshida, Masumi; Koshiyama, Masafumi; Fujii, Haruko; Konishi, Mitsunaga

doi:10.1016/s0140-6736(99)02273-4

Cited by 27 publications

(19 citation statements)

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“…Particularly, the production of Epo by uterine leiomyoma tissue has been confirmed by immunostaining [6,24], radioimmunoassay [6,24], reverse transcription polymerase chain reaction [5,25], enzyme-linked immunosorbent assay [5], and Southern blot analysis [25].…”

Section: Discussionmentioning

confidence: 95%

Erythropoietin and erythropoietin receptor system in a large uterine myoma of a patient with myomatous erythrocytosis syndrome: possible relationship with the pathogenesis of unusual tumor size

et al. 2005

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Section: Discussionmentioning

confidence: 95%

Erythropoietin and erythropoietin receptor system in a large uterine myoma of a patient with myomatous erythrocytosis syndrome: possible relationship with the pathogenesis of unusual tumor size

et al. 2005

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“…Yoshida et al [4] reported a case of myomatous erythrocytosis syndrome in which specific immunostaining for erythropoietin was seen in the cytoplasm of leiomyoma cells. They detected only the level of erythropoietin in leiomyoma tissue with erythrocytosis in comparison with these from the controls using radioimmunoassay.…”

Section: Discussionmentioning

confidence: 99%

Erythrocytosis due to an Erythropoietin-Producing Large Uterine Leiomyoma

Yokoyama¹,

Shinohara

Hirokawa

et al. 2003

Gynecol Obstet Invest

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Background: Various etiologies of myomatous erythrocytosis syndrome (erythrocytosis associated with a uterine leiomyoma), one of which is altered production of erythropoietin, have been proposed. We report a case of erythrocytosis associated with a large uterine leiomyoma in which erythropoietin activity and immunostaining for erythropoietin in the leiomyoma were found. Case: A 64-year-old woman, gravida 2, para 1, was referred to our department for treatment of a large uterine myoma and erythrocytosis with elevated levels of erythropoietin. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed, and the results of the pathological examination confirmed the diagnosis of leiomyoma of the uterus, which weighed 920 g. The patient’s postoperative course was satisfactory, and the levels of hemoglobin and erythropoietin were normalized and remained within normal ranges. The level of erythropoietin in the uterine leiomyoma measured by radioimmunoassay was elevated (372 mU/wet gram), and specific immunostaining for erythropoietin was found in the cytoplasm of leiomyoma cells. The levels of erythropoietin extracted from uterine leiomyomas of other patients who did not have erythrocytosis (control patients, n = 5) were lower (65 ± 15.3 mU/wet gram), but specific immunostaining for erythropoietin was also found in the cytoplasm of leiomyoma cells from those patients. Conclusions: Our case was typical of myomatous erythrocytosis syndrome in which uterine leiomyoma was proved to produce erythropoietin. Our results also suggest that erythropoietin is produced in uterine leiomyomas of patients with and without erythrocytosis. Leiomyoma of the uterus may affect the production of erythropoietin and may develop into myomatous erythrocytosis syndrome when the level of erythropoietin exceeds the normal range.

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“…Indeed, acute urinary retention secondary to a large fibroid was resolved after surgical intervention. Rare presentations should be considered, as the uterine leiomyoma is largely asymptomatic; these include polycythaemia,8 infertility,9 hypercalcaemia10 and hyperprolactinaemia 11. Our case represents a rare presentation of uterine leiomyoma as the patient had clinical symptoms of renal failure in the setting of underlying obstruction.…”

Section: Discussionmentioning

confidence: 85%

Unusual presentation of uterine leiomyoma

2015

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Uterine leiomyoma is the most common pelvic tumour in women. The presentation of uterine leiomyoma varies. Symptoms may include abnormal uterine bleeding or abdominal pressure and heaviness; however, most cases are asymptomatic. We report a case with renal impairment as the first presentation of uterine leiomyoma in a patient who presented with extensive bilateral lower limb oedema and no menstrual symptoms. Imaging studies, a subsequent Papanicolaou test and uterine biopsy were suggestive of uterine leiomyoma, which was confirmed by pathological examination after hysterectomy. The patient's kidney impairment resolved completely after the procedure.

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Erythrocytosis and a fibroid

Cited by 27 publications

References 1 publication

Erythropoietin and erythropoietin receptor system in a large uterine myoma of a patient with myomatous erythrocytosis syndrome: possible relationship with the pathogenesis of unusual tumor size

Erythropoietin and erythropoietin receptor system in a large uterine myoma of a patient with myomatous erythrocytosis syndrome: possible relationship with the pathogenesis of unusual tumor size

Erythrocytosis due to an Erythropoietin-Producing Large Uterine Leiomyoma

Unusual presentation of uterine leiomyoma

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