Erythrodermic cutaneous T cell lymphoma with hypereosinophilic syndrome: Treatment with interferon alfa and extracorporeal photopheresis

Abstract

A patient with erythroderma and concomitant diagnosis of "idiopathic" HES may warrant further investigation for CTCL.

Secondary hypereosinophilic syndrome: an unusual manifestation in a patient with syringotropic mycosis fungoides and human immunodeficiency virus infection

“…As reported in the literature, CTCLs are associated with peripheral blood eosinophilia in 14% of patients with plaque phase disease. 6 This is a result of the action of eosinophilopoietic cytokines secreted by neoplastic cells, including interleukins (IL) 4, 5 and 10. 7 On the other hand, in patients with HIV infection eosinophilia is found in up to 28% of the cases, 8,9 with higher rates in those with advanced disease.…”

Analytical Methods for Isolation, Separation and Identification of Selected Furanocoumarins in Plant Material

“…Their ability to covalently modify nucleic acids is used in process called "extracorporeal photopheresis" that is medically necessary for either of the following clinical indications: erythrodermic variants of cutaneous T-cell lymphoma (e.g. mycosis fungioides, Sezary's syndrome) or chronic graft-versus-host disease, refractory to standard immunosuppressive therapy (Hotlick et al, 2008;Lee et al, 2007).…”

The hypereosinophilic syndromes: current concepts and treatments

“…Recent reports have highlighted the protean clinical presentations of HES, including watershed cerebral infarction (McMillan et al , 2008), with sarcoma and granulocyte macrophage‐colony stimulating factor (GM‐CSF) production (Ando et al , 2007), orbital pseudotumour (Zenone & Ligeon‐Ligeonnet, 2005), retro‐orbital mass (Vigna et al , 2008), Budd Chiari syndrome (Becker et al , 2006; Inoue et al , 2007), erythroderma (Granjo et al , 2002; Lee et al , 2007), thrombosis of the cerebral superior sagital sinus (Sakuta et al , 2007), Kimura disease (Barge et al , 2008), Buerger disease (Kawata et al , 2007), lymphoma (Bae et al , 2007; Capovilla et al , 2008), with haemolytic anaemia and eosinophil erythrophagocytosis (Kuk et al , 2006), during pregnancy (Ogasa et al , 2006; Ault et al , 2009), with pemphigoid nodularis (von Felbert et al , 2006), with recurrent optic neuritis (Lincoff & Schlesinger, 2005), brachial artery occlusion (Ponsky et al , 2005), and, especially, with superficial venous thrombosis (Liao et al , 2005; Terrier et al , 2006; Sakuta et al , 2007). Mucosal ulcers of the mouth, genitalia and anus should alert the clinician to a particular variant, myeloproliferative HES (Leiferman et al , 1982; Leiferman & Gleich, 2004).…”