Erythrodermic Pustular Psoriasis Triggered by Subcutaneous Flu Vaccine

Abstract

A 59-year old man was admitted with severe pustular psoriasis all over his body that was triggered by a flu vaccine injection 8 days before admission. Until then, his psoriasis was under control and was noticed slightly only on extensor tendons of the hands and around the elbows. He was treated with steroids and the skin eruption disappeared slowly within 3 days. This is the first report of a patient with psoriasis who had a flare up of the autoimmune skin disease following vaccination.

Generalized Pustular Psoriasis Triggered by ChAdOx1nCoV-19 Vaccine: a case report

“…The main clinical manifestations are guttate and guttate-plaque variants 2,3 . GPP outbreaks following influenza, hepatitis B vaccination and intravesical BCG immunotherapy have been reported [8][9][10][11][12][13] (Table 1). Flares after COVID19 vaccination have included one case after COVID-19-Pfizer-BioNTechBNT16B2b2mRNA and two cases after ChAdOx1nCoV-19 vaccine (plaque lesions) and one case after Sinovac vaccines (GPP) [5][6][7] .…”

SARS‐CoV‐2 vaccination and practical points in psoriasis patients: A narrative review

“…The vaccine‐induced psoriasis is so prevalent that the term “psoriasis vaccinalis” has been suggested for vaccine‐induced new‐onset psoriasis 37 . New‐onset psoriasis or flare‐up has been reported following several vaccines, including yellow fever, tetanus‐diphteria, BCG, pneumococcal polysaccharide, and influenza vaccines 38–44 . A variety of clinical presentation of psoriasis have been reported in association with the latter vaccines such as plaque, guttate, erythrodermic, and pustular psoriasis 41,45,46 .…”

“…37 New‐onset psoriasis or flare‐up has been reported following several vaccines, including yellow fever, tetanus‐diphteria, BCG, pneumococcal polysaccharide, and influenza vaccines. 38 , 39 , 40 , 41 , 42 , 43 , 44 A variety of clinical presentation of psoriasis have been reported in association with the latter vaccines such as plaque, guttate, erythrodermic, and pustular psoriasis. 41 , 45 , 46 Accordingly, as the number of SARS‐CoV‐2 vaccinated psoriasis patients increases, the prevalence of vaccine‐induced consequences increases proportionately.…”