Erythroid proliferations in myeloid neoplasms

Wang, Sa A.

doi:10.1016/j.humpath.2011.08.008

Cited by 23 publications

(15 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[48][49][50] Another important use for these data sets is to develop a better mechanistic understanding of disordered erythropoiesis, with the ability to better understand stage-specific defects. This includes disorders such as the thalassemia syndromes, bone marrow failure syndromes and aplastic anemia [51][52][53][54][55][56] as well as acquired disorders such as the myelodysplasia syndromes, [57][58][59] particularly subtypes with disordered terminal erythroid differentiation. Numerous abnormalities have been identified in these disorders, including perturbed apoptosis, cytokine signaling, and regulation of cellular growth.…”

Section: Discussionmentioning

confidence: 99%

Global transcriptome analyses of human and murine terminal erythroid differentiation

Schulz

et al. 2014

Blood

316

340

View full text Add to dashboard Cite

• Transcriptome analyses of human and murine reveal significant stage and speciesspecific differences across stages of terminal erythroid differentiation.• These transcriptomes provide a significant resource for understanding mechanisms of normal and perturbed erythropoiesis.We recently developed fluorescence-activated cell sorting (FACS)-based methods to purify morphologically and functionally discrete populations of cells, each representing specific stages of terminal erythroid differentiation. We used these techniques to obtain pure populations of both human and murine erythroblasts at distinct developmental stages. RNA was prepared from these cells and subjected to RNA sequencing analyses, creating unbiased, stage-specific transcriptomes. Tight clustering of transcriptomes from differing stages, even between biologically different replicates, validated the utility of the FACSbased assays. Bioinformatic analyses revealed that there were marked differences between differentiation stages, with both shared and dissimilar gene expression profiles defining each stage within transcriptional space. There were vast temporal changes in gene expression across the differentiation stages, with each stage exhibiting unique transcriptomes. Clustering and network analyses revealed that varying stage-specific patterns of expression observed across differentiation were enriched for genes of differing function. Numerous differences were present between human and murine transcriptomes, with significant variation in the global patterns of gene expression. These data provide a significant resource for studies of normal and perturbed erythropoiesis, allowing a deeper understanding of mechanisms of erythroid development in various inherited and acquired erythroid disorders. (Blood. 2014;123(22):3466-3477) IntroductionMammalian erythropoiesis is an excellent example of the complex changes in temporal, developmental, and differentiation stage-specific gene expression exhibited by a single cell type.1,2 In the mammalian embryo and fetus, erythroid cells have differing developmental origins, with the primitive erythroid cell lineage developing from yolk sac-derived erythroid progenitors, and the definitive cell lineage maturing from 2 different developmentally regulated stem and progenitor cell populations. [3][4][5][6] These cells have different programs of regulation, with variation in spatial, temporal, and site-specific differentiation.In the adult, mature erythrocytes are the terminally differentiated final cellular product derived from hematopoietic stem and progenitor cells (HSPC). HSPCs undergo a series of lineage choice fate decisions, with increasingly restricted potential, ultimately committing to the erythroid lineage and beginning erythropoiesis. Traditionally, erythropoiesis has been divided into 3 stages: early erythropoiesis, terminal erythroid differentiation, and reticulocyte maturation.2 Early erythropoiesis involves commitment of multi-lineage progenitors into erythroid progenitor cells, with proliferation and d...

show abstract

Section: Discussionmentioning

confidence: 99%

Global transcriptome analyses of human and murine terminal erythroid differentiation

Schulz

et al. 2014

Blood

316

340

View full text Add to dashboard Cite

show abstract

“…Currently, there seems to be no consensus on this practice, and different hematologists follow different approaches in counting these cells. 8,9 This point needs resolution in the next version of the WHO classification. What Is the Relationship of AEL to MDS?…”

Section: Historical and Current Who Definitions Of Aelmentioning

confidence: 99%

Acute Erythroleukemias, Acute Megakaryoblastic Leukemias, and Reactive Mimics

Wang

2015

Am J Clin Pathol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Wang et al. reported an infantile erythroblastic sarcoma of the ovaries with cytogenetics involving the C‐MYB locus (6q23) …”

Section: Discussionmentioning

confidence: 99%

Pure Erythroid Leukemia Mimicking Ewing Sarcoma/Primitive Neuroectodermal Tumor in an Infant

Lapadat

Tower

Orazi³

et al. 2016

Pediatr Blood Cancer

View full text Add to dashboard Cite

Pure erythroid leukemia (PEL) is a rare type of acute myeloid leukemia (AML) with a very aggressive clinical course. Presentation as a myeloid/erythroid sarcoma is exceedingly rare. We describe an infantile PEL presenting as a multifocal myeloid sarcoma, clinically and pathologically mimicking Ewing sarcoma/PNET family of tumors. The patient died 8 weeks after the initial presentation due to widespread disease. Our case shows that PEL needs to be considered in the differential diagnosis of small round blue cell tumors in infancy. A meticulous workup including immunohistochemistry, flow cytometry, molecular, and cytogenetic studies was required to reach the diagnosis.

show abstract

Erythroid proliferations in myeloid neoplasms

Cited by 23 publications

References 60 publications

Global transcriptome analyses of human and murine terminal erythroid differentiation

Global transcriptome analyses of human and murine terminal erythroid differentiation

Acute Erythroleukemias, Acute Megakaryoblastic Leukemias, and Reactive Mimics

Pure Erythroid Leukemia Mimicking Ewing Sarcoma/Primitive Neuroectodermal Tumor in an Infant

Contact Info

Product

Resources

About