Erythroleukemia in a retrovirus-negative cat

Tan, Emmeline; Bienzle, Dorothee

doi:10.2460/javma.240.3.294

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…In fact, feline lymphoma has been reported to show a clearly poor prognosis in individuals infected with FeLV [3]. To date, almost all cases of MDS in cats involved FeLV infections, but outbreaks of FeLV-uninfected acute leukemia have been sporadically reported in recent years [4,26]. FeLV, an infectious agent that induces tumorigenesis, was not observed in this case, suggesting that the patient's prognosis may be favorable as a result.…”

Section: Azacytidine (Aza) a Methylation Inhibitor Has Recently Gaine...mentioning

confidence: 69%

A cat with myelodysplastic syndrome by administration of the methylation inhibitor Azacytidine

Hisasue

Tanaka

Neo

2022

The Journal of Veterinary Medical Science

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A 5-year-old female cat with nonregenerative anemia and thrombocytopenia was diagnosed with myelodysplastic syndromes (MDS), since peripheral blood and bone marrow (BM) examination revealed various dysplasias and a blast ratio of 19%. Chemotherapy with azacytidine (AZA; 70-35 mg/m 2 , 3-5 days, three cycles) and treatment with prednisolone, antibiotics, and vitamin K2, and blood transfusion were performed. On day 106, blast cells and dysplasia had decreased in the BM, and the cat remained alive for at least 1,474 days. This report is the first on feline MDS treated with AZA, suggesting appropriate drug dosage, interval and effective combination should be investigated and the pharmacological and cell biological mechanisms needs to be elucidated in the future.

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Section: Azacytidine (Aza) a Methylation Inhibitor Has Recently Gaine...mentioning

confidence: 69%

A cat with myelodysplastic syndrome by administration of the methylation inhibitor Azacytidine

Hisasue

Tanaka

Neo

2022

The Journal of Veterinary Medical Science

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“…Feline acute myeloid leukemia, subtype acute erythroid leukemia with erythroid dominance (AML M6-Er), is most frequently associated with feline leukemia virus (FeLV) infection and is often preceded by myelodysplastic syndrome (MDS). 7 Only one previous report has described AML M6-Er in a retrovirus-negative cat. 7 The underlying mechanism of AML M6-Er induction is unclear.…”

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confidence: 99%

“…7 Only one previous report has described AML M6-Er in a retrovirus-negative cat. 7 The underlying mechanism of AML M6-Er induction is unclear. Leukemia is classified as AML M6 when early erythroid precursors, such as rubriblasts, prorubricytes, and basophilic rubricytes, account for >50% of marrow cells and myeloblasts and monoblasts combined are >30% of all nucleated cells (ANC).…”

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Anti-CD71 antibody immunohistochemistry in the diagnosis of acute myeloid leukemia, subtype acute erythroid leukemia with erythroid dominance (AML M6-Er), in a retrovirus-negative cat

et al. 2020

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CD71 is an immunohistochemical marker used in diagnosing acute myeloid leukemia (AML) M6-Er in humans; however, to our knowledge, it has not been reportedly used for immunohistochemistry in veterinary medicine. We evaluated the pathologic features of AML M6-Er in a retrovirus-negative cat and used CD71 to support the diagnosis. A 4-y-old spayed female Scottish Fold cat was presented with lethargy, anorexia, and fever. Whole-blood PCR assay results for pro feline leukemia virus/pro feline immunodeficiency virus and feline vector-borne diseases were negative. Early erythroid precursors were observed in the peripheral blood smear. Fine-needle aspiration of the enlarged spleen and splenic lymph node showed many early erythroid precursors. Bone marrow aspirate smears revealed erythroid hyperplasia with 68.4% erythroid lineage and 3.6% rubriblasts. Dysplastic cells infiltrated other organs. The patient was diagnosed with myelodysplastic syndrome, progressing to the early phase of AML M6-Er. The patient died on day 121 despite multidrug treatments. Postmortem examination revealed neoplastic erythroblasts infiltrating the bone marrow and other organs. Neoplastic cells were immunopositive for CD71 but immunonegative for CD3, CD20, granzyme B, von Willebrand factor, CD61, myeloperoxidase, and Iba-1. Although further studies are necessary for the application of CD71, our results supported the morphologic diagnosis of AML M6-Er.

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Tumors of the Hemolymphatic System

Valli

Bienzle

Meuten

2016

Tumors in Domestic Animals

107

242

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Erythroleukemia in a retrovirus-negative cat

Abstract: To the authors' knowledge, erythroleukemia has only been reported in cats infected with FeLV. However, results of all diagnostic assays for FeLV were negative in the cat reported here, which suggested that erythroleukemia can develop in cats in the absence of FeLV infection.

Cited by 7 publications

References 12 publications

A cat with myelodysplastic syndrome by administration of the methylation inhibitor Azacytidine

A cat with myelodysplastic syndrome by administration of the methylation inhibitor Azacytidine

Anti-CD71 antibody immunohistochemistry in the diagnosis of acute myeloid leukemia, subtype acute erythroid leukemia with erythroid dominance (AML M6-Er), in a retrovirus-negative cat

Tumors of the Hemolymphatic System

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