Erythromycin as Therapy for Acute Colonic Pseudo-Obstruction (Ogilvieʼs Syndrome)

Bonacini, Maurizio; Smith, Owen J.

doi:10.1097/00004836-199108000-00024

Cited by 40 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Armstrong et al [26] reported decompression in two patients with ACPO who were treated with oral erythromycin (500 mg four times daily) for 10 days. In another report, a patient with ACPO had resolution after 3 days of intravenous erythromycin [27]. The potential of newly developed motilin receptor agonists to stimulate colonic motility remains to be determined.…”

Section: Other Pharmacologic Therapymentioning

confidence: 99%

See 1 more Smart Citation

Acute colonic pseudoobstruction

Saunders

2004

Curr Gastroenterol Rep

View full text Add to dashboard Cite

Acute colonic pseudoobstruction (ACPO) is a clinical condition of acute large bowel obstruction without mechanical blockage. ACPO occurs most often in hospitalized patients with serious underlying medical and surgical conditions. ACPO is an important cause of morbidity and mortality. The pathogenesis of ACPO is not completely understood but likely results from an imbalance in the autonomic regulation of colonic motor function. Metabolic or pharmacologic factors, as well as spinal or retroperitoneal trauma, may alter the autonomic regulation of colonic function, leading to excessive parasympathetic suppression or sympathetic stimulation. This imbalance results in colonic atony and pseudoobstruction. Early recognition and appropriate management are critical to minimizing morbidity and mortality. The mortality rate is estimated at 40% when ischemia or perforation occurs. The best documented treatment of ACPO is intravenous neostigmine, which leads to prompt decompression in the majority of patients after a single infusion. In patients failing or having contraindications to neostigmine, colonoscopic decompression is the active intervention of choice. Surgery is reserved for those with overt peritonitis or perforation.

show abstract

Section: Other Pharmacologic Therapymentioning

confidence: 99%

“…Erythromycin, a motilin receptor agonist, was found to be successful in a few case reports [26,27]. Armstrong et al [26] reported decompression in two patients with ACPO who were treated with oral erythromycin (500 mg four times daily) for 10 days.…”

Section: Other Pharmacologic Therapymentioning

confidence: 99%

Acute colonic pseudoobstruction

Saunders

2004

Curr Gastroenterol Rep

View full text Add to dashboard Cite

show abstract

“…Erythromycin is a motilin receptor agonist that has been shown to decompress the bowel in a few case reports [60] . In one study erythromycin improved gastric emptying and intestinal transit measured by sulphamethizole methods and radio opaque markers, respectively [61] .…”

Section: Medical Treatmentmentioning

confidence: 99%

Colonic Pseudo-Obstruction

Zaidi¹

2012

Current Concepts in Colonic Disorders

View full text Add to dashboard Cite

“…Falls nach zweimaliger Anwendung keine klinische Wirkung erzielt werden kann, ist die Indikation zur koloskopischen Dekompression gegeben. Zu den weiteren motilitätsanregenden Substanzen gehören Erythromycin [10,11] …”

Section: Fallbeschreibungunclassified