Erythromycin enhances abomasal emptying in healthy unweaned lambs as shown by acetaminophen absorption test

Fazeli, Mehdi; Shomali, Tahoora; Firouzi, Masoumeh; Ghane, Mohsen

doi:10.1111/j.1365-2885.2011.01345.x

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…Our previous findings indicated that apigenin and quercetin as well as hederagenin and medicagenic acid significantly affect the contractility of bovine abomasum and duodenum smooth muscle (Mendel et al, 2016a(Mendel et al, , 2016b. Therefore, we hypothesized that all of previously tested PSM might be able to modify the effect of pharmaceutical (Nouri et al, 2008;Wittek et al, 2008;Fazeli, Shomali, Firouzi, & Ghane, 2012) in addition to the main activity, that is, antibacterial, anti-inflammatory and anthelminthic, respectively. Their contractile impact towards gut smooth muscle observed in vivo is consistent with our findings obtained from experiments performed on bovine isolated abomasum and duodenum strips (Figures 1, 2 and 3).…”

Section: Discussionmentioning

confidence: 98%

“…However, due to the limited bioavailability of flavonoids and saponins in ruminants, the findings including the low dose of PSM require major attention. Erythromycin, flunixin meglumine and levamisole are examples of medicines of confirmed prokinetic effect (Nouri et al., ; Wittek et al., ; Fazeli, Shomali, Firouzi, & Ghane, ) in addition to the main activity, that is, antibacterial, anti‐inflammatory and anthelminthic, respectively. Their contractile impact towards gut smooth muscle observed in vivo is consistent with our findings obtained from experiments performed on bovine isolated abomasum and duodenum strips (Figures , and ).…”

Section: Discussionmentioning

confidence: 99%

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Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility—in vitro study

Mendel

Chłopecka

Dziekan

et al. 2017

Vet Pharm & Therapeutics

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Continued ingestion of plant secondary metabolites by ruminants can provoke pharmacological interactions with pharmaceutical agents used in animals. As some drugs and phytocompounds affect smooth muscle activity, the aim of this study was to verify the possible interaction between selected pharmaceutical agents and plant secondary metabolites towards bovine gastrointestinal motility. The interactions between phytocompounds-apigenin, quercetin, hederagenin, medicagenic acid-and medicines-erythromycin, flunixin meglumine and levamisole-were evaluated on bovine isolated abomasal and duodenal specimens obtained from routinely slaughtered cows. The obtained results confirmed the contractile effect of all three drugs used solely. Hederagenin and medicagenic acid (0.001 μM) enhanced the contractile effect of levamisole. Hederagenin additionally increased the impact of erythromycin. Both saponins (100 μM) showed synergistic effects with all tested pharmaceuticals. Apigenin and quercetin (0.001 μM) intensified the contractile response induced by erythromycin and levamisole. Moreover, both flavonoids (100 μM) showed an antagonistic interaction with all tested drugs which in that situation were devoid of the prokinetic effect. To conclude, plant metabolic metabolites such as saponins and flavonoids are potent modifiers of the effect of drugs towards gut motility. The synergy observed between phytocompounds and selected medicines can be beneficial in the treatment of cows with hypomotility disorders.

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