Erythromycin in pityriasis rosea: A double-blind, placebo-controlled clinical trial☆, ☆☆

Sharma, Prafulla Kumar; Yadav, Tribhuvan Pal; Gautam, R. K.; Taneja, Neelam; Labani, Satyanarayana

doi:10.1016/s0190-9622(00)90132-4

Cited by 126 publications

(89 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Use of new garments or old garments in storage for prolonged period have been suggested as precipitating factors for pityriasis rosea, indicative of a transmissible infectious agent [8]. A chance observation of improvement of skin lesions of pityriasis rosea in two patients who were given erythromycin for upper respiratory tract infections, also confirms this hypothesis [9]. It has already been established that drugs like allopurinol, arsenic, bismuth, barbiturate, gold, hydrochlorothiazide, organic mercurials, nimesulide, d-penicillamine, clonidine, isotretinoin and ketotifen can cause eruptions resembling pityriasis rosea [10][11][12].…”

Section: Introductionmentioning

confidence: 80%

See 1 more Smart Citation

A Randomized, Double-blind, Placebo-Controlled Study of Efficacy of Oral Acyclovir in the Treatment of Pityriasis Rosea

Ganguly¹

2014

JCDR

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 80%

“…Sharma et al, [9] had conducted a double blind, placebo-controlled trial using oral erythromycin stearate in adults (250 mg q.i.d. X 2 weeks) and children (25 to 40 mg q.i.d.)…”

Section: Discussionmentioning

confidence: 99%

A Randomized, Double-blind, Placebo-Controlled Study of Efficacy of Oral Acyclovir in the Treatment of Pityriasis Rosea

Ganguly¹

2014

JCDR

View full text Add to dashboard Cite

“…Erythromycin has been used in PR after incidental observation of improvement in some patients with PR while receiving erythromycin. 15 The main limitation to the study was the small sample …”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14] On the other hand, oral Erythromycin is a timetested drug which is reported to be beneficial to patients with PR. 15 However, recent clinical experiences suggest macrolides, including Azithromycin and Erythromycin, are of no value in the treatment of PR. 16,17 The aim of this study is to compare the effectiveness of empiric oral Erythromycin treatment with high dose oral Acyclovir targeting HHV7 and HHV6, in the management of PR.…”

Section: Original Articlementioning

confidence: 99%

Comparative Study of Effectiveness of Oral Acyclovir with Oral Erythromycin in the Treatment of Pityriasis Rosea

Amatya

Rajouria

Karn

2012

Kathmandu Univ. Med. J.

View full text Add to dashboard Cite

BackgroundPityriasis rosea is an acute, self-limiting disease, probably infective in origin, affecting mainly children and young adults, characterized by distinctive skin eruptions and minimal constitutional symptoms. Both oral Erythromycin and oral Acyclovir have been used in its management. ObjectivesTo compare the effectiveness of oral Erythromycin and oral Acyclovir in the treatment of Pityriasis rosea. MethodForty two patients with clinical diagnosis of Pityriasis rosea were enrolled. They were randomized into two groups. One group was given high-dose oral Acyclovir and another group oral Erythromycin in standard dose. The participants were evaluated one, two, four, six and eight weeks and six months after commencement of the study. ResultsForty two patients including 26 males and 16 females completed the study. After 8th week, all patients showed complete response in both the groups. The response to oral Acyclovir compared with that to oral Erythromycin was better and was statistically significant in 1st, 2nd, 4th and 6th weeks. ConclusionAlthough it is a self-limiting disease which resolves within three weeks to three months, this study reveals that both oral Acyclovir and oral Erythromycin are helpful in decreasing the severity and duration of Pityriasis rosea. Moreover, the study also indicates that oral Acyclovir is more effective than oral Erythromycin in reducing the severity and duration of Pityriasis rosea.

show abstract

“…La duración del cuadro puede disminuir con el uso de eritromicina por vía oral cuando se administra en la primera semana del exantema diseminado, disminuyendo el tiempo de evolución que se resuelve, en 73% de los casos, en dos semanas. 18 Es recomendable que el paciente evite la exposición directa al sol en el sitio de las lesiones porque la escama de la placa evitará el bronceado y dejará una mancha hipocrómica en su lugar, aunque ésta es temporal y se resuelve espontáneamente es muy notoria en niños de piel morena.…”

Section: Tratamientounclassified

Pitiriasis rosada: un exantema que debe ser reconocido por el médico de primer contacto. Estudio de 30 casos

et al. 2014

View full text Add to dashboard Cite

289www.actapediatrica.org.mx Acta Pediátr Mex 2014;35:289-294. artículo original Pitiriasis rosada: un exantema que debe ser reconocido por el médico de primer contacto. Estudio de 30 casos RESUMEN Antecedentes: la pitiriasis rosada es un exantema agudo diseminado de etiología desconocida y duración prolongada. Se caracteriza por placas eritematosas con un collarete de escama periférica. Aunque el cuadro clínico es aparatoso para el paciente y el familiar, la pitiriasis rosada es involutiva y generalmente remite sin secuelas. Frecuentemente es confundida con micosis y se prescriben tratamientos innecesarios.Objetivo: describir las características clínicas y demográficas de la pitiriasis rosada en un grupo de pacientes pediátricos mexicanos.Pacientes y métodos: estudio retrospectivo y descriptivo en el que se analizaron las características clínicas y demográficas de los pacientes evaluados en el Servicio de Dermatología del Instituto Nacional de Pediatría con diagnóstico de pitiriasis rosada en un periodo de 10 años.Resultados: se encontraron treinta pacientes con pitiriasis rosada para una frecuencia de 3.6 por cada 1 000 pacientes dermatológicos. Predominio en mujeres con una relación de 1.5:1 y edad promedio de 10 años. En más de la mitad de los casos (56%) se observaron formas atípicas que hicieron necesaria la toma de biopsia en 7 pacientes para establecer el diagnóstico definitivo.Conclusiones: el conocimiento de las características clínicas de la pitiriasis rosada, por médicos de primer contacto, evitará tratamientos y exámenes innecesarios. Pityriasis Rosea: A rash that should be recognized by the primary care physician. Study of 30 cases ABSTRACT Background: Pityriasis rosea is an acute disseminated rash of unknown etiology and prolonged duration, characterized by erythematoussquamous plaques. Despite having an ostentatious clinical picture for both the patient and family, it is self-limited and usually resolves without sequelae. Pityriasis rosea is often erroneously diagnosed as mycosis and given unnecessary treatment.

show abstract

Erythromycin in pityriasis rosea: A double-blind, placebo-controlled clinical trial☆, ☆☆

Cited by 126 publications

References 20 publications

A Randomized, Double-blind, Placebo-Controlled Study of Efficacy of Oral Acyclovir in the Treatment of Pityriasis Rosea

A Randomized, Double-blind, Placebo-Controlled Study of Efficacy of Oral Acyclovir in the Treatment of Pityriasis Rosea

Comparative Study of Effectiveness of Oral Acyclovir with Oral Erythromycin in the Treatment of Pityriasis Rosea

Pitiriasis rosada: un exantema que debe ser reconocido por el médico de primer contacto. Estudio de 30 casos

Contact Info

Product

Resources

About