Erythromycin in the Short- and Long-term Control of Dyspepsia Symptoms in Patients with Gastroparesis

Dhir, Rohtashav; Richter, Joel E.

doi:10.1097/00004836-200403000-00008

Cited by 81 publications

(38 citation statements)

References 44 publications

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“…Since the duration of postoperative abomasal hypomotility is unknown (Wittek et al 2005), erythromycin was applied three times at intervals of 24 h in the Emy3 study group. In human medicine, low doses of this drug are administered repeatedly to increase gastric emptying in patients with gastroparesis and, thus, to facilitate a sustained clinical benefit (Dhir and Richter 2004).…”

Section: Discussionmentioning

confidence: 99%

Effects of erythromycin on milk yield, rumen contraction rate and blood beta-hydroxybutyrate concentration in dairy cows after laparoscopic reposition of the left displaced abomasum

Freick¹,

Weber²,

Passarge³

et al. 2016

Vet. Med. - Czech

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ABSTRACT:The objective of this study was to evaluate the beneficial effects of erythromycin (Emy), a prokinetic drug active at the level of the abomasum, duodenum and proximal duodenum, in dairy cows undergoing a laparoscopic repositioning of left abomasal displacement (LAD). A total of 71 German Holstein cows were randomly assigned into three groups. Cows of the group Emy1 received erythromycin once preoperatively (10 mg/kg; intramuscularly). Animals of the group Emy3 were additionally treated twice after surgery at intervals of 24 h each (10 mg/kg; intramuscularly), while cows in the control group did not receive erythromycin. The milk yield of the patients was documented on Days 0, 1, 2, 3, 6 and 10 and the rumen contraction rate (RCR) was determined on Days 1 and 3. Additionally, the measurement of the concentration of beta-hydroxybutyrate (BHB) in whole blood samples was performed on Days 0, 1 and 3. Significant differences between the study groups regarding the cure rates, milk yield (in relation to Day 0); BHB concentrations and RCR could not be determined on the observation dates. With respect to a prudent use of antibiotics in livestock, the application of erythromycin as a prokinetic drug cannot be recommended for the present in cows undergoing a laparoscopic correction of LAD.Keywords: cattle; dislocatio abomasi; endoscopy; prokinetic drugs; gastrointestinal mobility List of abbreviations BHB = beta-hydroxybutyrate; DIM = days in milk; Emy = erythromycin; GIT = gastro-intestinal tract; LAD = left abomasal displacement; NSAID = non-steroidal anti-inflammatory drug; RCR = rumen contraction rate

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Section: Discussionmentioning

confidence: 99%

Effects of erythromycin on milk yield, rumen contraction rate and blood beta-hydroxybutyrate concentration in dairy cows after laparoscopic reposition of the left displaced abomasum

Freick¹,

Weber²,

Passarge³

et al. 2016

Vet. Med. - Czech

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“…In a comprehensive review, Camilleri 47 concluded that erythromycin is most useful in acute gastroparesis and recommended a regimen that begins with intravenous erythromycin lactobionate (3 mg/kg every 8 hours) and continues with oral administration (250 mg three times a day) for 5 to 7 days. 47 Efficacy with long-term oral administration has been less obvious 48,49 and may be complicated by the risks associated with long-term antibiotic use 49 ; in general, data remains scanty. 50 There is also evidence that the salutory response to erythromycin may be blunted by hyperglycemia.…”

Section: Macrolidesmentioning

confidence: 99%

Prokinetics in the Management of Functional Gastrointestinal Disorders

Quigley

2017

Curr Gastroenterol Rep

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A variety of common and some not common gastrointestinal syndromes are thought to be based on impaired gut motility. For some, the role of motility is well defined, for others and the functional gastrointestinal disorders, in particular, the role of hypo-or dysmotility remains unclear. Over the years pharmacological and physiological laboratories have developed drugs which stimulate gut motility; many have been evaluated in motility and functional disorders with what can best be described as mixed results. Lack of receptor specificity and resultant expected and unexpected adverse events have led to the demise of some of these agents. Newer, more selective agents offer promise but the heterogeneity of the clinical disorders they target continues to pose a formidable challenge to drug development in this area.

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“…The sample size was never more than 13 and the treatment duration was 4 weeks. Two recent studies, again with small sample sizes, have reported conflicting results regarding the effectiveness of ER in the treatment of gastroparesis [18,19].…”

Section: Off-label Administration Of Erythromycinmentioning

confidence: 99%

Erythromycin as a prokinetic agent: Risk factors

Berthet

Charpiat

Mabrut

2010

Journal of Visceral Surgery

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Erythromycin (ER) is an antibiotic with prokinetic activity. This property has led to its clinical use to improve gastric emptying in patients with gastroparesis. Several papers have reported the effectiveness of ER in such patients; however few of these studies have been well-conducted methodologically with evaluation of clinical endpoints and their results are often contradictory. A benefit/risk analysis prior to prescription of ER should take into account the numerous medication interactions of this drug as well as the prevention of cardiovascular complications, most notably torsade de pointes and cardiac arrest. The aim of this paper was to provide new insights into these adverse events and allow for better-informed prescription. Risk prevention requires prescription guidelines and effective communication among surgeons, anesthesiologists and pharmacists.

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Erythromycin in the Short- and Long-term Control of Dyspepsia Symptoms in Patients with Gastroparesis

Abstract: Treatment of gastroparesis with low-dose erythromycin and low-bulk diet results in a dramatic short-term improvement in the majority of patients. Short-term response predicts long-term response. This response may not be as great, possibly due to tachyphylaxis.

Cited by 81 publications

References 44 publications

Effects of erythromycin on milk yield, rumen contraction rate and blood beta-hydroxybutyrate concentration in dairy cows after laparoscopic reposition of the left displaced abomasum

Effects of erythromycin on milk yield, rumen contraction rate and blood beta-hydroxybutyrate concentration in dairy cows after laparoscopic reposition of the left displaced abomasum

Prokinetics in the Management of Functional Gastrointestinal Disorders

Erythromycin as a prokinetic agent: Risk factors

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