Erythrophagocytic Tγ Lymphoma

Kadin, Marshall E.; Kamoun, Malek; Lamberg, John

doi:10.1056/nejm198103123041106

Cited by 229 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diagnosis of this type of lymphoma is based mainly on the demonstration of NK cell markers on the lymphoma cells. However, since one of the NK cell markers, CD 16 (marker for Fc receptor of IgG), is also detected on lymphoma cells of other groups, such as the erythrophagocytic Ty lymphoma [32] and hepatosplenic T-cell lymphoma [33,34], a morphologic identity of this type of lymphoma should be sought. The histologic cell type of this lymphoma varies from well-differentiated small cell, small cleaved cell, large cell, large cell immunoblastic, and lymphoblastic, to mixed small and large cell [S-151.…”

Section: Discussionmentioning

confidence: 99%

A study of lymphoma of large granular lymphocytes with modern modalities: Report of two cases and review of the literature

et al. 1992

View full text Add to dashboard Cite

Two cases of lymphoma of large granular lymphocytes are reported. The first case expressed natural killer (NK) cell, some T-cell (CD 2, CD 5, CD 8), and HLA-DR antigens, but was negative for other T-cell (CD 3, CD 4, CD 7), T-cell receptor (TCR), B-cell, and myeloid antigens. Germline configuration was demonstrated for TCR, and immunoglobulin heavy and light chain genes. The second case expressed NK cell, some T-cell (CD 3, CD 7, CD 8), and TCR antigens, but was negative for other T-cell (CD 4, CD 5), B-cell, myeloid, and HLA-DR antigens. Rearrangement of TCR alpha and beta chains were detected. Thus, the findings of case 1 were consistent with true NK cell lineage and case 2 with NK-like T-cell lineage. Our report underscores the heterogeneity of this newly recognized lymphoma, which nevertheless carries a consistently poor prognosis and is probably more prevalent in the Asian population. This study also provides information concerning immunophenotypes of cellular infiltrates in internal organs and cytogenetic abnormalities in this lymphoma; neither has been reported frequently in the literature. The importance of detecting cytoplasmic granules in tissue imprints or electron micrographs for differentiating other T-cell lymphomas is emphasized, and the classification of large granular lymphoproliferative disorders is discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

A study of lymphoma of large granular lymphocytes with modern modalities: Report of two cases and review of the literature

et al. 1992

View full text Add to dashboard Cite

show abstract

“…Sheep rosette-forming cells (SRFC), surface membrane immunoglobulin (slg)-bearing PBMC, mouse rosette-forming cells (MRFC) and cells posi tive for the receptor of the Fc portion of IgG (FcyR) were determined as previously described [10]. PBMC were studied with a panel of commercially available monoclonal antibodies, and with the following rea gents: 5/9 antibody recognizes T lymphocytes with helper activity [5]; 20.2 reacts with monocytes [7]; helper and inducible suppressor T cells are included among 3A1-positive cells [10]; anti-Tac monoclonal antibody recognizes the receptor for human T-cell growth factor [12]. Antibodies were used in an indi rect immunofluorescence test as previously described [ 10].…”

Section: Surface Markersmentioning

confidence: 99%

Unusual Phenotype (Leu 7+, OKT4+, OKMl+) Expressed by Cells from a Patient with an Abnormal Expansion of Granular Lymphocytes

Quinti¹,

Pacilli²,

Zoli³

et al. 1984

Acta Haematol

View full text Add to dashboard Cite

We report the case of a 70-year-old female with a lymphocytosis which was casually detected during a routine examination. Immunological studies revealed the expansion of granular lymphocytes (GL) with the following, previously undescribed phenotype: Leu 7⁺, OKT3⁺ , OKT4⁺, OKT8^-, OKM1⁺ . These cells were tested for their functional activities and found to exert neither helper nor suppressor functions in in vitro tests. Cytotoxic activities demonstrated a strong ADCC and a markedly reduced NK function. 1 year later the clinical course has remained good without any treatment and we suggest that this case should be classified as an abnormal expansion of GL, despite the OKT4 positivity of the cells. Our data point out the importance of a careful immunological study of cells from these rare patients and suggest the existence of a normal GL population expressing the OKT4 phenotype, which is possibly expanded in this patient.

show abstract

“…Sjogren syndrome, SLE and/or their related conditions may involve an increased risk of CHP and/or lymphproliferative disorders. CHP is occasionally found in patients with lymphoma/leukemia (3,4,17), and viral infections such as that from the Epstein-Barr virus (18). Various explanations have been proposed for the etiology and pathogenesis of this disorder: 1) associated viral infection (18), 2) mediation through Fc receptors on tumor cells (17), and 3) lymphokines secreted from tumor cells (19) are considered to be phagocytosis-inducing factors.…”

Section: Discussionmentioning

confidence: 99%

A Case of Cytophagic Histiocytic Panniculitis with Sicca Symptoms and Lupus Nephritis

Tsukahara¹,

Fujioka²,

Horiuchi³

et al. 1992

The Journal of Dermatology

View full text Add to dashboard Cite

A 48-year-old Japanese woman presented with many subcutaneous nodules. The skin was purplish in color and tender; the nodules were scattered over the entire surface. Histological findings of biopsy specimens from the nodules indicated septal panniculitis comprised of histiocyte and/or macrophage infiltrates, often with erythro- and/or leukophagocytosis. Phagocytic cells were OKM1 (CD11b), MT1 (CD43), LeuM3 (CD14), and histiocyte antigen positive, indicating the presence of histiocytes and/or macrophages. The patient had sicca symptoms, positive homogenous, speckled pattern ANA (x320), and diffuse proliferative lupus nephritis.

show abstract

Erythrophagocytic Tγ Lymphoma

Cited by 229 publications

References 22 publications

A study of lymphoma of large granular lymphocytes with modern modalities: Report of two cases and review of the literature

A study of lymphoma of large granular lymphocytes with modern modalities: Report of two cases and review of the literature

Unusual Phenotype (Leu 7<sup>+</sup>, OKT4<sup>+</sup>, OKMl<sup>+</sup>) Expressed by Cells from a Patient with an Abnormal Expansion of Granular Lymphocytes

A Case of Cytophagic Histiocytic Panniculitis with Sicca Symptoms and Lupus Nephritis

Contact Info

Product

Resources

About