Erythroplasia of Queyrat treated with topical methyl aminolevulinate photodynamic therapy

Abstract

An 82-year-old man presented with invasive squamous cell carcinoma of the glans penis arising in erythroplasia of Queyrat. He underwent Mohs' micrographic surgery for the invasive carcinoma. Seven weeks later, the residual erythroplasia of Queyrat was treated using photodynamic therapy. Methyl aminolevulinate cream was applied to the glans of the penis under occlusion for 3 hours and then, after local anaesthesia, irradiated with a 630-nm red-light-emitting diode lamp at a dose of 37 J/cm(2) for 8 min. The patient experienced some mild swelling, redness and pain, which subsided over the following 5 days. Eighteen weeks after photodynamic therapy, there had been no recurrence of the lesion, when the patient died from an unrelated cause.

Eritroplasia e leucoeritroplasia oral: análise retrospectiva de 13 casos

“…Surgical excision is the treatment of choice made by most healthcare professionals; it was done in six of the 13 cases. Other treatments have been proposed, such as: topical retinoic acid with systemic beta-carotens; 22 photodynamic therapy with methyl aminolevulinate; 23 and cryosurgery or vaporization with carbon dioxide laser radiation. 24 These approaches also include cessation of risk factors.…”

Methylaminolaevulinic Acid Photodynamic Therapy in the Treatment of Erythroplasia of Queyrat

“…Although the small number of reported cases (5 patients to date [8,9]) does not allow a relevant statistical comparison of the success of this therapy, our results document a favourable outcome after PDT for some of the patients and underline the importance of repeated treatment. Indeed, the mean number of PDT sessions in our patient collective was 12.3 in the complete response group, 10.3 in the partial remission group, whereas it was only 2.8 in the progression group.…”

“…Two further patients with more extensive disease achieved partial response after 2 cycles of 5-aminolaevulinic acid PDT and required laser vaporization [8]. Lee and Ryman [9] reported an 82-year-old patient with invasive squamous cell carcinoma of the glans penis arising in EQ. While he underwent Mohs micrographic surgery for his invasive carcinoma, his residual EQ was treated by PDT.…”

“…Indeed, the mean number of PDT sessions in our patient collective was 12.3 in the complete response group, 10.3 in the partial remission group, whereas it was only 2.8 in the progression group. The patients of Stables et al [8] had 1–2 cycles, that of Lee and Ryman [9] 1 cycle of therapy only. We think therefore that the success of the PDT therapy for EQ is closely linked to the number of sessions, and that patients treated by this method need to be regularly followed clinically.…”

“…While he underwent Mohs micrographic surgery for his invasive carcinoma, his residual EQ was treated by PDT. Eighteen weeks after completion of one cycle of treatment, he had no evidence of recurrence [9]. …”