Erythropoietin and Ovarian Cancer – Response

Solár, Peter; Kovaľ, Ján; Mikeš, Jaromír; Kleban, Ján; Solárová, Zuzana; Lazúr, Ján; Hodorová, Ingrid; Fedoročko, Peter; Sytkowski, Arthur J.

doi:10.1158/1535-7163.mct-09-1217

Cited by 3 publications

(2 citation statements)

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“…The acquired resistance of A2780cis cells was maintained by supplementation of media with 1 µM of cisplatin every second passage. 22 Cell viability assay. A2780 and A2780cis cells were seeded into 96-well culture plates at a concentration of 3×10 3 and 6×10 3 cells per well, respectively.…”

Section: Cellular Studiesmentioning

confidence: 99%

Photocytotoxic Pt(iv) complexes as prospective anticancer agents

et al. 2019

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Section: Cellular Studiesmentioning

confidence: 99%

Photocytotoxic Pt(iv) complexes as prospective anticancer agents

et al. 2019

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“…Cisplatin-based chemotherapy is a primary treatment for ovarian cancer. However, the resistance to cisplatin remains a major obstacle in the effective treatment of ovarian cancers [1][2][3][4]. Deactivating cisplatin -resistant ovarian cells is an urgent task.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic action of LED-activated pyropheophorbide-αmethyl ester in cisplatinresistant human ovarian carcinoma cells

Tan

Xia

et al. 2009

Laser Phys. Lett.

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Cisplatin-resistance is a major obstacle for the successful therapy to ovarian cancer, and exploring novel approach to deactivate cisplatin-resistant ovarian cells will improve the clinical outcomes. Our present study showed that there was no dark cytotoxicity of MPPa in the COC1/DDP cells at the dose of 0.25 -4 μM, and LED-activated MPPa resulted in drug doseand light-dependent cytotoxicity. Apoptotic rate 6 h after LEDactivated MPPa (2 μM) increased to 16.71% under the light energy of 1 J/cm 2 . Confocal laser scanning microscopy showed that MPPa mainly localized in the intracellular membrane system, namely the endoplasmic reticulum, Golgi apparatus, lysosomes and mitochondria in the COC1/DDP cells. Mitochondrial membrane potential (ΔΨm) was collapsed when COC1/DDP cells were exposed to 2 μM MPPa for 20 h and then 1 J/cm 2 irradiation of LED source. These data demonstrated that LEDactivated MPPa significantly deactivated cisplatin-resistant ovarian cell line COC1/DDP cells and enhanced apoptosis and decreased ΔΨ m , which suggests LED is an efficient light source for PDT and LED-activated MPPa can be developed as new modality for treating cisplatin-resistant ovarian.The setup of light source from a light emitting diode (LED) at the wavelength of 630 nm and the power density from 1 to 130 mW/cm 2 distributing uniformly over an area of 78.5 cm 2

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The Neurobiology of Erythropoietin

Sytkowski

2011

Cell Mol Neurobiol

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Erythropoietin and Ovarian Cancer – Response

Cited by 3 publications

References 7 publications

Photocytotoxic Pt(iv) complexes as prospective anticancer agents

Photocytotoxic Pt(iv) complexes as prospective anticancer agents

Photodynamic action of LED-activated pyropheophorbide-αmethyl ester in cisplatinresistant human ovarian carcinoma cells

The Neurobiology of Erythropoietin

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