Erythropoietin attenuates experimental haemorrhagic shock-induced renal damage through an iNOS- dependent mechanism in male Wistar rats

Ranjbaran, Mina; Kadkhodaee, Mehri; Seifi, Behjat; Adelipour, Maryam; Azarian, Bahareh

doi:10.1016/j.injury.2017.01.010

Cited by 10 publications

(3 citation statements)

References 26 publications

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“…EPO and its derivatives such as helix B surface peptide (HBSP) revealed protective effects in transplant-related renal injuries such as ischemia-reperfusion injury (IRI) and immunosuppressant nephrotoxicity [ 98 ]. Renoprotection of EPO was demonstrated via modulation of the STAT6/MAPK/NF-κB pathway, ERK/p53 signaling [ 99 , 100 ], and via the PI3K/AKT activated NOS/NO pathway [ 101 , 102 ].…”

Section: Epor/pi3k/akt and Epor/mapk In Non-hematopoietic Tissuesmentioning

confidence: 99%

The Role of PI3K/AKT and MAPK Signaling Pathways in Erythropoietin Signalization

Tóthová

Šemeláková

Solárová

et al. 2021

IJMS

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Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on various types of cells and tissues. EPO and its receptor EPOR trigger signaling cascades JAK2/STAT5, MAPK, and PI3K/AKT that are interconnected and irreplaceable for cell survival. In this article, we describe the role of the MAPK and PI3K/AKT signaling pathways during red blood cell formation as well as in non-hematopoietic tissues and tumor cells. Although the central framework of these pathways is similar for most of cell types, there are some stage-specific, tissue, and cell-lineage differences. We summarize the current state of research in this field, highlight the novel members of EPO-induced PI3K and MAPK signaling, and in this respect also the differences between erythroid and non-erythroid cells.

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Section: Epor/pi3k/akt and Epor/mapk In Non-hematopoietic Tissuesmentioning

confidence: 99%

The Role of PI3K/AKT and MAPK Signaling Pathways in Erythropoietin Signalization

Tóthová

Šemeláková

Solárová

et al. 2021

IJMS

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“…Erythropoietin (EPO) is a pleiotropic hormone whose primary function is to stimulate erythropoiesis. Its target receptors are expressed in several cell types including skeletal muscle [42][43][44][45][46][47][48][49]. EPO has a tissue protective potential, including anti-inflammation, anti-apoptosis, and improving metabolic alteration [48,[50][51][52][53].…”

Section: Ivyspringmentioning

confidence: 99%

Erythropoietin Alleviates Burn-induced Muscle Wasting

Tai

et al. 2020

Int. J. Med. Sci.

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Background: Burn injury induces long-term skeletal muscle pathology. We hypothesized EPO could attenuate burn-induced muscle fiber atrophy. Methods: Rats were allocated into four groups: a sham burn group, an untreated burn group subjected to third degree hind paw burn, and two burn groups treated with weekly or daily EPO for four weeks. Gastrocnemius muscle was analyzed at four weeks post-burn. Results: EPO attenuated the reduction of mean myofiber cross-sectional area post-burn and the level of the protective effect was no significant difference between two EPO-treated groups (p=0.784). Furthermore, EPO decreased the expression of atrophy-related ubiquitin ligase, atrogin-1, which was up-regulated in response to burn. Compared to untreated burn rats, those receiving weekly or daily EPO groups had less cell apoptosis by TUNEL assay. EPO decreased the expression of cleaved caspase 3 (key factor in the caspase-dependent pathway) and apoptosis-inducing factor (implicated in the caspase-independent pathway) after burn. Furthermore, EPO alleviated connective tissue overproduction following burn via transforming growth factor beta 1-Smad2/3 pathway. Daily EPO group caused significant erythrocytosis compared with untreated burn group but not weekly EPO group. Conclusion: EPO therapy attenuated skeletal muscle apoptosis and fibrosis at four weeks post-burn. Weekly EPO may be a safe and effective option in muscle wasting post-burn.

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“…We have previously reported that administration of EPO (300 IU/kg, i.v.) 10 min prior to HS induction, reduced renal dysfunction by activation of survival pathway (activated Akt pathway) and reduction in the apoptotic process (reduced caspase 3 activity) (Ranjbaran et al 2017b). However, the exact mechanisms mediating these beneficial effects of EPO on tissues are not fully clear and warrant further research.…”

Section: Shammentioning

confidence: 99%

Resuscitative therapy with erythropoietin reduces oxidative stress and inflammatory responses of vital organs in a rat severe fixed-volume hemorrhagic shock model

Ranjbaran

Kadkhodaee²,

Seifi³

et al. 2018

gpb

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Hemorrhagic shock (HS) still has a high mortality rate and none of the known resuscitative regimens completely reverse its adverse outcomes. This study investigated the effects of different models of resuscitative therapy on the healing of organ damage in a HS model. Male Wistar rats were randomized into six groups: Sham, without HS induction; HS, without resuscitation; HS+Blood, resuscitation with the shed blood; HS+Blood+NS, resuscitation with blood and normal saline; HS+Blood+RL, resuscitation with blood and Ringer's lactate; EPO, erythropoietin was added to the blood and RL. Blood and urine samples were obtained 3 h after resuscitation. Kidney, liver and brain tissue samples were harvested for multiple organ failure evaluation. Survival rate was the highest in the Sham, EPO and HS+Blood+RL groups compared to others. Plasma creatinine concentration, ALT, AST, urinary NAG activity and renal NGAL mRNA expression significantly increased in the HS+Blood+RL group compared to the Sham group. There was a significant increase in tissue oxidative stress markers and pro-inflammatory cytokines in HS+Blood+RL group compared to the Sham rats. EPO had more protective effects on multiple organ failure compared to the HS+Blood+RL group. EPO, as a resuscitative treatment, attenuated HS-induced organ damage. It seems that it has a potential to be attractive for clinical trials.

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Erythropoietin attenuates experimental haemorrhagic shock-induced renal damage through an iNOS- dependent mechanism in male Wistar rats

Cited by 10 publications

References 26 publications

The Role of PI3K/AKT and MAPK Signaling Pathways in Erythropoietin Signalization

The Role of PI3K/AKT and MAPK Signaling Pathways in Erythropoietin Signalization

Erythropoietin Alleviates Burn-induced Muscle Wasting

Resuscitative therapy with erythropoietin reduces oxidative stress and inflammatory responses of vital organs in a rat severe fixed-volume hemorrhagic shock model

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