Erythropoietin in Diabetic Macular Edema and Renal Insufficiency

Friedman, Eli A.; Brown, Chris; Herman, Damir

doi:10.1097/00006982-199501560-00021

Cited by 3 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In diabetic retinopathy, EPO administration was observed to improve macular oedema, stable vision and fluorescein angiography (Ref. 127). However, elevated EPO and VEGF were found in the vitreous fluid of patients with proliferative diabetic retinopathy and branch retinal vein occlusion (Ref.…”

Section: Erythropoietin and Vascular Endotheliummentioning

confidence: 99%

“…However, elevated EPO and VEGF were found in the vitreous fluid of patients with proliferative diabetic retinopathy and branch retinal vein occlusion (Ref. 127). A recently discovered polymorphism in the EPO gene promoter is linked to elevated EPO levels in the vitreous body and to diabetic retinopathy, suggesting a possible causal relationship (Ref.…”

Section: Erythropoietin and Vascular Endotheliummentioning

confidence: 99%

See 1 more Smart Citation

Survival and proliferative roles of erythropoietin beyond the erythroid lineage

Noguchi

Wang

Rogers

et al. 2008

Expert Rev. Mol. Med.

View full text Add to dashboard Cite

Since the isolation and purification of erythropoietin (EPO) in 1977, the essential role of EPO for mature red blood cell production has been well established. The cloning and production of recombinant human EPO led to its widespread use in treating patients with anaemia. However, the biological activity of EPO is not restricted to regulation of erythropoiesis. EPO receptor (EPOR) expression is also found in endothelial, brain, cardiovascular and other tissues, although at levels considerably lower than that of erythroid progenitor cells. This review discusses the survival and proliferative activity of EPO that extends beyond erythroid progenitor cells. Loss of EpoR expression in mouse models provides evidence for the role of endogenous EPO signalling in nonhaematopoietic tissue during development or for tissue maintenance and/or repair. Determining the extent and distribution of receptor expression provides insights into the potential protective activity of erythropoietin in brain, heart and other nonhaematopoietic tissues.

show abstract

Section: Erythropoietin and Vascular Endotheliummentioning

confidence: 99%

Section: Erythropoietin and Vascular Endotheliummentioning

confidence: 99%

Survival and proliferative roles of erythropoietin beyond the erythroid lineage

Noguchi

Wang

Rogers

et al. 2008

Expert Rev. Mol. Med.

View full text Add to dashboard Cite

show abstract

“…42 Recent studies indicate that intravitreal EPO is a potentially interesting treatment option in retinal disease, although data are limited. [12][13][14][15][16][17] It is noteworthy that eyes examined less than 1 week after injection showed slightly decreased VEGF levels and central macular thickness after intravitreal EPO. In contrast, eyes examined 1 month after injection showed increased VEGF levels and central macular thickness.…”

Section: Discussionmentioning

confidence: 98%

“…11 Systemic administration of EPO to treat azotemia-induced anaemia in diabetic patients demonstrated a beneficial effect on macular oedema and improved visual outcomes. [12][13][14] Following the study of EPO toxicity and pharmacokinetics, dosages and schedules were designed for human intravitreal injections of EPO. 15,16 In addition, intravitreal EPO has shown a short-term positive effect in diabetic macular oedema.…”

Section: Introductionmentioning

confidence: 99%

Aqueous humour levels of vascular endothelial growth factor and erythropoietin in patients with diabetic macular oedema before and after intravitreal erythropoietin injection

Lim

Han

2011

Clinical &Amp; Experimental Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Iron deficiency anaemia, either alone or with vitamin B12 deficiency, rapidly increases the risk of PDR pathogenesis (Shorb 1985). The treatment of iron deficiency anaemia promotes tissue oxygenation and reduces VEGF production; these effects further halt neovascularization stimulation and improve hyperpermeability (Friedman et al 1995). Low vitamin B12 concentrations increase the risk of vascular damage by homocysteine, hinder retinal arteriole dilation through NO-mediated pathways and induce apoptosis in retinal ganglion cells by increasing the levels of the highly expressed proapoptotic Bcl-2-associated X protein in diabetic retinas (Satyanarayana et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Bariatric surgery might aggravate proliferative diabetic retinopathy

Sever

Horozoğlu

2020

Acta Ophthalmologica

View full text Add to dashboard Cite

This study aimed to assess the changes experienced by patients with proliferative diabetic retinopathy (PDR) after bariatric surgery (BS). Methods: This retrospective observational study includes 37 eyes of 21 patients with PDR who underwent BS at a tertiary university hospital over the period of 2014-2018. The control group (CG) comprised 37 eyes of 27 patients with PDR who attended the same research hospital for diabetes care without undergoing BS. Preoperative and postoperative glycated haemoglobin (HbA1c) levels, weight and diabetic retinopathy screening results were collected from the medical records of the patients. Patients who had undergone preoperative retinal screening and at least one postoperative retinal screening were included in the analysis. Results: Both groups exhibited statistically significant visual acuity (VA) loss at 6 months and 1 year (p < 0.001). At postoperative 6 months the VA loss experienced by the control BS group was significantly more severe than that experienced by the CG (p = 0.03). The first-year HbA1c levels of the BS group were significantly lower than those of the CG (p = 0.02). The BS group had significantly higher intraocular haemorrhage (p = 0.04), neovascular glaucoma (p = 0.04) and retinal vein occlusion (p = 0.04) rates than the CG group. All complications occurred at different patients. Conclusion: Patients with PDR who received BS showed more severe retinopathy than patients who were matched for age, sex, HbA1c levels and follow-up duration and who did not receive BS.

show abstract

Erythropoietin in Diabetic Macular Edema and Renal Insufficiency

Cited by 3 publications

References 0 publications

Survival and proliferative roles of erythropoietin beyond the erythroid lineage

Survival and proliferative roles of erythropoietin beyond the erythroid lineage

Aqueous humour levels of vascular endothelial growth factor and erythropoietin in patients with diabetic macular oedema before and after intravitreal erythropoietin injection

Bariatric surgery might aggravate proliferative diabetic retinopathy

Contact Info

Product

Resources

About