Erythropoietin levels in children with obstructive sleep apnea

Kalogritsas, Nick; Lachanas, Vassilios A.; Liakos, Panagiotis; Alexopoulos, Emmanouel Ι.; Beka, Despoina; Petinaki, Efthymia; Hajiioannou, Jiannis; Simos, George

doi:10.1016/j.ijporl.2021.110932

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Data from 90 children were analysed and the study demonstrated a higher level of EPO in children affected by OSAS and its correlation with AHI score. The inconstant O2 tension overnight in OSAS patients activates the hypoxia-inducible factor 2 (HIF-2) that regulates transcription of several genes, including EPO: 2 h of continuous hypoxia as well as 4 h of intermittent hypoxia results in a 50% increase of EPO [ 88 ]. Another potential diagnostic tool for children affected by SDB is the exhaled breath profile analysis using the E-nose technology that detects the volatile compounds in exhaled breath.…”

Section: What Is the Role Of Alternative Diagnostic Tools In The Diag...mentioning

confidence: 99%

Diagnosis of Paediatric Obstructive Sleep-Disordered Breathing beyond Polysomnography

Borrelli,

Corcione,

Cimbalo

et al. 2023

Children

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Obstructive sleep-disordered breathing (SDB) has significant impacts on health, and therefore, a timely and accurate diagnosis is crucial for effective management and intervention. This narrative review provides an overview of the current approaches utilised in the diagnosis of SDB in children. Diagnostic methods for SDB in children involve a combination of clinical assessment, medical history evaluation, questionnaires, and objective measurements. Polysomnography (PSG) is the diagnostic gold standard. It records activity of brain and tibial and submental muscles, heart rhythm, eye movements, oximetry, oronasal airflow, abdominal and chest movements, body position. Despite its accuracy, it is a time-consuming and expensive tool. Respiratory polygraphy instead monitors cardiorespiratory function without simultaneously assessing sleep and wakefulness; it is more affordable than PSG, but few paediatric studies compare these techniques and there is optional recommendation in children. Nocturnal oximetry is a simple and accessible exam that has high predictive value only for children at high risk. The daytime nap PSG, despite the advantage of shorter duration and lower costs, is not accurate for predicting SDB. Few paediatric data support the use of home testing during sleep. Finally, laboratory biomarkers and radiological findings are potentially useful hallmarks of SDB, but further investigations are needed to standardise their use in clinical practice.

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Section: What Is the Role Of Alternative Diagnostic Tools In The Diag...mentioning

confidence: 99%

Diagnosis of Paediatric Obstructive Sleep-Disordered Breathing beyond Polysomnography

Borrelli,

Corcione,

Cimbalo

et al. 2023

Children

View full text Add to dashboard Cite

show abstract

“…There is some evidence to suggest that OSA is associated with a pro-inflammatory state, with raised cytokines, which may result in these changes [13,15]. Erythropoietin has been suggested as a potential biomarker candidate for paediatric OSA [16]. In a study of 115 children (mean age 6.8 years), 86 children with OSA had significantly higher serum erythropoietin levels compared to non-OSA children (29 children), their levels correlating with AHI [16].…”

Section: Underlying Mechanisms For Cardiovascular Changesmentioning

confidence: 99%

“…Erythropoietin has been suggested as a potential biomarker candidate for paediatric OSA [16]. In a study of 115 children (mean age 6.8 years), 86 children with OSA had significantly higher serum erythropoietin levels compared to non-OSA children (29 children), their levels correlating with AHI [16]. Another postulated mechanism is elevated sympathetic drive caused by frequent arousals and intermittent hypoxia.…”

Section: Underlying Mechanisms For Cardiovascular Changesmentioning

confidence: 99%

Recent advances in paediatric sleep disordered breathing

Garde

Gibson

Samuels

et al. 2022

Breathe

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This article reviews the latest evidence pertaining to childhood sleep disordered breathing (SDB), which is associated with negative neurobehavioural, cardiovascular and growth outcomes. Polysomnography is the accepted gold standard for diagnosing SDB but is expensive and limited to specialist centres. Simpler tests such as cardiorespiratory polygraphy and pulse oximetry are probably sufficient for diagnosing obstructive sleep apnoea (OSA) in typically developing children, and new data-processing techniques may improve their accuracy. Adenotonsillectomy is the first-line treatment for OSA, with recent evidence showing that intracapsular tonsillectomy results in lower rates of adverse events than traditional techniques. Anti-inflammatory medication and positive airway pressure respiratory support are not always suitable or successful, although weight loss and hypoglossal nerve stimulation may help in select comorbid conditions.Educational aimsTo understand the clinical impact of childhood sleep disordered breathing (SDB).To understand that, while sleep laboratory polysomnography has been the gold standard for diagnosis of SDB, other diagnostic techniques exist with their own benefits and limitations.To recognise that adenotonsillectomy and positive pressure respiratory support are the mainstays of treating childhood SDB, but different approaches may be indicated in certain patient groups.

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Respiratory Arrest in an Obese Teenager in PACU After Cardiac Catheterization

Perez-Velasco¹

2023

Anesthesia STAT! Acute Pediatric Emergencies in PACU

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Erythropoietin levels in children with obstructive sleep apnea

Cited by 4 publications

References 15 publications

Diagnosis of Paediatric Obstructive Sleep-Disordered Breathing beyond Polysomnography

Diagnosis of Paediatric Obstructive Sleep-Disordered Breathing beyond Polysomnography

Recent advances in paediatric sleep disordered breathing

Respiratory Arrest in an Obese Teenager in PACU After Cardiac Catheterization

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