Erythropoietin Plays a Protective Role in Submandibular Gland Hypofunction Induced by Irradiation

Liu, Qilin; Wang, Yue; Cui, Zhi; Ma, Xiaozhou; Shi, Haibo; Zhang, Wei

doi:10.1016/j.joms.2020.12.001

Cited by 2 publications

(3 citation statements)

References 32 publications

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“…Erythropoietin, an endogenous glycoprotein hormone, increases when IR damages SG microvessels, ischemia, and hypoxia. Recombinant human erythropoietin has been shown to balance SOD and ROS levels [ 56 , 66 ]. Notably, recombinant human erythropoietin administration may also activate erythropoietin receptors in cancer cells, making them IR resistant [ 66 ].…”

Section: Preventionmentioning

confidence: 99%

“…Recombinant human erythropoietin has been shown to balance SOD and ROS levels [ 56 , 66 ]. Notably, recombinant human erythropoietin administration may also activate erythropoietin receptors in cancer cells, making them IR resistant [ 66 ]. The specific mechanism of erythropoietin function in the glands and methods to reduce its tumor-protective effect are aspects of future research.…”

Section: Preventionmentioning

confidence: 99%

Section: Antioxidantsmentioning

confidence: 99%

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Diagnosis, Prevention, and Treatment of Radiotherapy-Induced Xerostomia: A Review

Pang

et al. 2022

Journal of Oncology

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In patients with head and neck cancer, irradiation (IR)-sensitive salivary gland (SG) tissue is highly prone to damage during radiotherapy (RT). This leads to SG hypofunction and xerostomia. Xerostomia is defined as the subjective complaint of dry mouth, which can cause other symptoms and adversely affect the quality of life. In recent years, diagnostic techniques have constantly improved with the emergence of more reliable and valid questionnaires as well as more accurate equipment for saliva flow rate measurement and imaging methods. Preventive measures such as the antioxidant MitoTEMPO, botulinum toxin (BoNT), and growth factors have been successfully applied in animal experiments, resulting in positive outcomes. Interventions, such as the new delivery methods of pilocarpine, edible saliva substitutes, acupuncture and electrical stimulation, gene transfer, and stem cell transplantation, have shown potential to alleviate or restore xerostomia in patients. The review summarizes the existing and new diagnostic methods for xerostomia, along with current and potential strategies for reducing IR-induced damage to SG function. We also aim to provide guidance on the advantages and disadvantages of the diagnostic methods. Additionally, most prevention and treatment methods remain in the stage of animal experiments, suggesting a need for further clinical research, among which we believe that antioxidants, gene transfer, and stem cell transplantation have broad prospects.

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Section: Preventionmentioning

confidence: 99%