Erythropoietin prevents ischemia-reperfusion from inducing oxidative damage in fetal rat brain

Solaroğlu, İhsan; Solaroglu, Ayse; Kaptanoğlu, Erkan; Dede, Suat; Haberal, Alı; Beşkonaklı, Etem; Kılınç, Kamer

doi:10.1007/s00381-002-0680-2

Cited by 97 publications

(33 citation statements)

References 27 publications

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“…Moreover, varying evidence points to the efficacy of EPO against HIE in rodent and primate models, since this hormone exhibits anti-inflammatory, anti-apoptotic and antioxidant effects [58,59], as detailed below. Nevertheless, the cellular mechanisms by which EPO exerts neuroprotection are not completely understood [51].…”

Section: New Approaches To Antioxidant Therapymentioning

confidence: 99%

Role of Antioxidants in Neonatal Hypoxic–Ischemic Brain Injury: New Therapeutic Approaches

Arteaga

Álvarez

Revuelta

et al. 2017

IJMS

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Hypoxic–ischemic brain damage is an alarming health and economic problem in spite of the advances in neonatal care. It can cause mortality or detrimental neurological disorders such as cerebral palsy, motor impairment and cognitive deficits in neonates. When hypoxia–ischemia occurs, a multi-faceted cascade of events starts out, which can eventually cause cell death. Lower levels of oxygen due to reduced blood supply increase the production of reactive oxygen species, which leads to oxidative stress, a higher concentration of free cytosolic calcium and impaired mitochondrial function, triggering the activation of apoptotic pathways, DNA fragmentation and cell death. The high incidence of this type of lesion in newborns can be partly attributed to the fact that the developing brain is particularly vulnerable to oxidative stress. Since antioxidants can safely interact with free radicals and terminate that chain reaction before vital molecules are damaged, exogenous antioxidant therapy may have the potential to diminish cellular damage caused by hypoxia–ischemia. In this review, we focus on the neuroprotective effects of antioxidant treatments against perinatal hypoxic–ischemic brain injury, in the light of the most recent advances.

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Section: New Approaches To Antioxidant Therapymentioning

confidence: 99%

Role of Antioxidants in Neonatal Hypoxic–Ischemic Brain Injury: New Therapeutic Approaches

Arteaga

Álvarez

Revuelta

et al. 2017

IJMS

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“…Another tissue-protective mechanism of EPO is its ability to protect cells against oxidative damage [75,76]. EPO inhibits lipid peroxidation by increasing the activities of cytosolic antioxidant enzymes such as superoxide dismutase and glutathione peroxidase [77-79].…”

Section: Multimodal Neuroprotective Profilementioning

confidence: 99%

Erythropoietin: a multimodal neuroprotective agent

Byts

Sirén

2009

Exp & Trans Stroke Med

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The tissue protective functions of the hematopoietic growth factor erythropoietin (EPO) are independent of its action on erythropoiesis. EPO and its receptors (EPOR) are expressed in multiple brain cells during brain development and upregulated in the adult brain after injury. Peripherally administered EPO crosses the blood-brain barrier and activates in the brain anti-apoptotic, anti-oxidant and anti-inflammatory signaling in neurons, glial and cerebrovascular endothelial cells and stimulates angiogenesis and neurogenesis. These mechanisms underlie its potent tissue protective effects in experimental models of stroke, cerebral hemorrhage, traumatic brain injury, neuroinflammatory and neurodegenerative disease. The preclinical data in support of the use of EPO in brain disease have already been translated to first clinical pilot studies with encouraging results with the use of EPO as a neuroprotective agent.

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“…1 Ischaemiareperfusion injury is known to occur in the central nervous system, and has also been shown in the tissues of the liver, kidney and heart. 2 Similar to the central nervous system, the skin is also vulnerable to acute ischaemic injury because of its high lipid content. Skin changes in intrauterine ischaemia have been shown in animal models of chronic ischaemia 3,4 but not in acute ischaemia.…”

Section: Introductionmentioning

confidence: 99%