¿Es tiempo de vacunar a la mujer embarazada contra la coqueluche?

Cofré, José

doi:10.4067/s0716-10182016000100008

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…If this vaccination in pregnant women reaches high coverage, pertussis deaths in children younger than 6 months should decrease and even disappear in children born from mothers already vaccinated during gestation 5 18 . The same group, through a retrospective analysis, showed that children of mothers vaccinated during pregnancy with Tdap and who were infected with pertussis had less severe manifestations of the disease, which it results in a lower rate of hospitalization and/or admission to critical patient unit (95% confidence interval (CI): 49% -85%) and 58% (95% CI: 15% -80%), compared to those who were born from unvaccinated mothers, establishing an effectiveness of 72%, in relation to hospitalization prevention 26 .…”

Section: Effectiveness and Safety Of Tdap Antenatal Vaccinementioning

confidence: 99%

“…It was decided to vaccinate the postpartum women, as well as parents of every newborn, siblings and relatives of 12 years and older, including caregivers, who lived and shared all day with the newborn, in addition to vaccination of health care providers whom work with pediatric patients. The total coverage reached was 91% in postpartum women and 60% in other groups, however, given the high number of members in chilean families, it is not possible to sustain this strategy over time, due to Pertussis vaccination during pregnancy -R. Villena et al its cost, which is clearly high, and its optimal coverage is very difficult to fulfill, which enables frames of susceptibility for the infant to the B. pertussis infection 5,12 . This type of vaccination during pregnancy has been considered as one of the most gentle and effective strategies to reduce morbidity and mortality in children younger than 6 months of age 1,[13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

“…The mortality rate has remained stationary, without many changes, with about 0.4 per 100,000 inhabitants, corresponding to the fifth cause of immune preventable deaths 1,3 . There are no specific mortality rates available for those children younger than 6 months, however, children of this age group die every year for pertussis [3][4][5][6] ( figure 1 and table 1). …”

Section: Introductionmentioning

confidence: 99%

“…This type of vaccination during pregnancy has been considered as one of the most gentle and effective strategies to reduce morbidity and mortality in children younger than 6 months of age 1,[13][14][15] . Its main objective is to promote the transfer of placental antibodies to the fetus and to protect it during the period of greatest risk of a severe pertussis infection, while patient completes its primary immunization schedule with 3 doses 1,5,16 .…”

Section: Introductionmentioning

confidence: 99%

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Vacunación con pertussis en el embarazo: una estrategia segura y efectiva para proteger al lactante menor

Villena

Vidal²,

Carrillo

et al. 2017

Rev. chil. pediatr.

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Vacunación con pertussis en el embarazo: una estrategia segura y efectiva para proteger al lactante menor Keywords:Whooping cough, Bordetella pertussis, diphtheria-tetanuspertussis vaccine AbstractWhooping cough is an immune preventable disease that can be life threatening. Despite infant immunization starting at 2 month of age, there are many cases and outbreaks in our country and also around the world, with a high risk of mortality especially in infants under 6 month of age. It has been proposed that antenatal vaccination with acellular pertussis component (Tdap) would be useful, safe and effective since it transfers a high antibody rate to the child, reducing the incidence of pertussis in this group by 85%. No higher incidence of adverse effects has been found in pregnant women with this vaccine. This strategy has been implemented in several developed and Latin American countries. The purpose of this manuscript is to review and discuss the benefits of antenatal vaccination with Tdap. It was concluded that maternal immunization with Tdap vaccine should be promoted to prevent infection and associated mortality in infants under 6 months of age by Bordetella pertussis.

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Section: Effectiveness and Safety Of Tdap Antenatal Vaccinementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Vacunación con pertussis en el embarazo: una estrategia segura y efectiva para proteger al lactante menor

Villena

Vidal²,

Carrillo

et al. 2017

Rev. chil. pediatr.

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Inmunizaciones en el adulto: una mirada hacia las poblaciones especiales

Vergara-Pinto,

Herrera-Morgado

2024

Revista Médica Clínica Las Condes

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Detection of IgM, IgG and IgA against pertussis in pregnant women in I - II - III trimesters

Skirda

Borisova

Gadua

et al. 2021

jour

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Purpose: to investigate the level anti-pertussis IgM, IgG, IgA in pregnant women in the I — II — III trimesters. Materials and methods. A total of 288 pregnant women aged. 17 — 43 years (in the I — II — III trimesters) were examined. A serums samples tested for IgM, IgG, IgA against pertussis by ELISA of RIDASCREEN (Germany). Results. Anti-pertussis IgG concentration below the low limit of detection occurred in 75,7% of pregnant women. The majority of seropositive among pregnant women was in the age group 26 — 35 years (82,9%). The proportion of seronegative among pregnant women increased. with increasing pregnancy periods, as well as depending on age. In III trimester IgG were detected in 18,2% of pregnant women. The most seronegative among pregnant women were in the III trimester and at the age of over 36 years old. The detection of IgM, IgG and IgA made it possible to detect the active infection process in 11 (3,9%) pregnant women by elevated level of IgA. High IgA level only in combination with IgM was in serum sample from 1 pregnant woman, high IgA level in combination with IgG at negative values of IgM was in serum samples from 8 pregnant woman. Only IgA in serum sample from 2 pregnant women (I and III trimesters of pregnancy) were detected. This is probably due to the presence of whooping cough or mucosal contamination with B.pertussis (persisting IgA). Conclusion. The serological studies have shown the need to develop algorithms for protecting newborns — from, the moment pregnant women are registered, to the onset of childbirth. These algorithms will provide information about on the presence of whooping cough and will help prevent infection of the newborn.

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¿Es tiempo de vacunar a la mujer embarazada contra la coqueluche?

Cited by 3 publications

References 6 publications

Vacunación con pertussis en el embarazo: una estrategia segura y efectiva para proteger al lactante menor

Vacunación con pertussis en el embarazo: una estrategia segura y efectiva para proteger al lactante menor

Inmunizaciones en el adulto: una mirada hacia las poblaciones especiales

Detection of IgM, IgG and IgA against pertussis in pregnant women in I - II - III trimesters

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