In this study, the presence of permafrost layer and its potential variation in the last three decades will be examined through the multitemporal analysis of satellite data in the area of the Deosai Plateau (Northern Pakistan). In the area, only global maps on the potential presence of permafrost layer are known. The results are based on the evaluation of variation of the number and water levels of the small lakes, and the changes of the extensions of the wetlands. The adopted methodology is based on the use of spectral indices and visual interpretation of a time-series data of Landsat images in the range 1990–2019, and on the processing of radar data from Sentinel 1 satellites, adopting new methods to extract the vertical displacement. The main findings are: (i) a high temporal dynamic of the number and surface areas of small lakes, and (ii) the evidence of a subduction in a wetland area (Black Hole), coherent with its extension, and suggesting the potential presence of a permafrost layer slowly degrading. This analysis can play a useful role on the management of the Deosai National Park (DNP), adopting careful measures for the human activities inside the park.