Escalating the Global Fight Against Neglected Tropical Diseases Through Interventions in the Asia Pacific Region

Hotez, Peter J.; Ehrenberg, John P.

doi:10.1016/s0065-308x(10)72002-9

Cited by 82 publications

(49 citation statements)

References 65 publications

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“…China has witnessed huge economic and social improvements over the past 30 years, hotspots of soil-transmitted helminthiasis and other neglected tropical diseases persist, 35 with ethnic minority groups particularly vulnerable and thus, less benefiting from the country's development. 36,37 Post-treatment re-infection patterns of soil-transmitted helminths are largely dependent on the degree of endemicity within the community. 38,39 In the current high endemicity area of P.R.…”

Section: Discussionmentioning

confidence: 99%

Rapid Re-Infection with Soil-Transmitted Helminths after Triple-Dose Albendazole Treatment of School-Aged Children in Yunnan, People's Republic of China

Yap

Du²,

Fang-wei³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. Post-treatment soil-transmitted helminth re-infection patterns were studied as part of a randomized controlled trial among school-aged children from an ethnic minority group in Yunnan province, People's Republic of China. Children with a soil-transmitted helminth infection (N = 194) were randomly assigned to triple-dose albendazole or placebo and their infection status monitored over a 6-month period using the Kato-Katz and Baermann techniques. Baseline prevalence of Trichuris trichiura, Ascaris lumbricoides, hookworm, and Strongyloides stercoralis were 94.5%, 93.3%, 61.3%, and 3.1%, respectively, with more than half of the participants harboring triple-species infections. For the intervention group (N = 99), the 1-month post-treatment cure rates were 96.7%, 91.5%, and 19.6% for hookworm, A. lumbricoides, and T. trichiura, respectively. Egg reduction rates were above 88% for all three species. Rapid re-infection with A. lumbricoides was observed: the prevalence 4 and 6 months post-treatment was 75.8% and 83.8%, respectively. Re-infection with hookworm and T. trichiura was considerably slower.

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Section: Discussionmentioning

confidence: 99%

Rapid Re-Infection with Soil-Transmitted Helminths after Triple-Dose Albendazole Treatment of School-Aged Children in Yunnan, People's Republic of China

Yap

Du²,

Fang-wei³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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“…A recent analysis of NTDs in SSA (sub-Saharan Africa) identified Nigeria as a country with the greatest number of cases of STH infections (Hotez and Kamath, 2009) and ranked fourth or fifth globally behind China, India and Indonesia (DeSilva et al 2003;Hotez and Ehrenberg, 2010;Lobo et al 2011;Tchuem Tchuenté et al 2013).…”

Section: Introductionmentioning

confidence: 99%

A preliminary survey of school-based water, sanitation, hygiene (WASH) resources and soil-transmitted helminthiasis in eight public schools in Odeda LGA, Ogun State, Nigeria

et al. 2017

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This cross-sectional study was undertaken to assess the status of school-based water, sanitation and hygiene (WASH) resources and soil-transmitted helminthiasis (STH) in Odeda, Ogun State, Nigeria. The status and condition of WASH resources were determined in eight selected schools (three with WASH support and five without). Stool samples were also collected from 428 pupils from both school categories and screened for STH infections. Findings showed that water and sanitation conditions of WASH resource programming schools were better than those in schools without WASH support. However, pupils' knowledge about STH infections and basic hygiene were not significantly different between both categories of school (P > 0·05). The prevalence of Hookworm, Ascariasis and Trichuriasis cases recorded were 26·2, 18·2 and 1·6% respectively, with an overall prevalence of 33·4%. By school categories, Ascariasis (14·9 vs 20·6), Hookworm (17·7 vs 32·0), Trichuriasis (1·7 vs 1·6) and, any STH prevalence (27·4 vs 37·5) were recorded for schools with WASH resource programming and those without respectively. A greater portion of the infected children 95 (66·4%) were from schools without WASH support. Our findings imply that WASH resource may have very positive impact on the control of STH among school children. However, there is need for improvement on coverage, adequacy and maintenance of WASH facilities in school.

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“…Soil-related Helminth infections (Acariasis, Trichuriasis and Hookworm infections) debilitate many children and leave them socially ostracized and chronically anemic through poor hygiene and lack of prevention or educational resources [56]. Lymphatic filariasis (elephantiasis) causes social ostracization and dysmorphic effects from unnatural swelling of the lymph nodes.…”

Section: Food Security and Malnourishmentmentioning

confidence: 99%

Fragile States, Infectious Disease and Health Security: The Case for Timor-Leste

Quinn

Martins

Cunha

et al. 2014

Journal of Human Security

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Timor-Leste is a very young and developing nation state. Endemic infectious disease and weakened health security coupled with its growing and inclusive public institutions keep Timor-Leste fragile and in transition on the spectrum of state stability. The objective here is to systematically review Timor-Leste's state and public health successes, showing how a fragile state can consistently improve its status on the continuum of stability and improve health security for the population. The case study follows a state case study approach, together with a disease burden review and a basic description of the health portrait in relation to Timor-Leste's fragile state status. Disease burden and health security are directly proportional to state stability and indirectly proportional to state failure. Timor-Leste is a clear example of how public health can feed into increased state stability. Our discussion attempts to describe how the weak and fragile island nation of Timor-Leste can continue on its current path of transition to state stability by increasing health security for its citizens. We surmise that this can be realized when public policy focuses on primary healthcare access, inclusive state institutions, basic hygiene and preventative vaccination programs. Based on our review, the core findings indicate that by

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Escalating the Global Fight Against Neglected Tropical Diseases Through Interventions in the Asia Pacific Region

Cited by 82 publications

References 65 publications

Rapid Re-Infection with Soil-Transmitted Helminths after Triple-Dose Albendazole Treatment of School-Aged Children in Yunnan, People's Republic of China

Rapid Re-Infection with Soil-Transmitted Helminths after Triple-Dose Albendazole Treatment of School-Aged Children in Yunnan, People's Republic of China

A preliminary survey of school-based water, sanitation, hygiene (WASH) resources and soil-transmitted helminthiasis in eight public schools in Odeda LGA, Ogun State, Nigeria

Fragile States, Infectious Disease and Health Security: The Case for Timor-Leste

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