1983
DOI: 10.1016/s0140-6736(83)91167-4
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Escherichia Coli Cytotoxin, Haemolytic-Uraemic Syndrome, and Haemorrhagic Colitis

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Cited by 183 publications
(129 citation statements)
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“…Enterohemorrhagic E. coli (EHEC) O157:H7 is a potentially fatal food-borne pathogen that can cause hemorrhagic colitis (9) and the hemolytic uremic syndrome (HUS) (10). Hallmarks of EHEC pathogenicity are the production of intestinal attaching and effacing (AE) lesions (11) and the secretion of potent Shiga toxins, which are responsible for the HUS (10).…”
mentioning
confidence: 99%
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“…Enterohemorrhagic E. coli (EHEC) O157:H7 is a potentially fatal food-borne pathogen that can cause hemorrhagic colitis (9) and the hemolytic uremic syndrome (HUS) (10). Hallmarks of EHEC pathogenicity are the production of intestinal attaching and effacing (AE) lesions (11) and the secretion of potent Shiga toxins, which are responsible for the HUS (10).…”
mentioning
confidence: 99%
“…Hallmarks of EHEC pathogenicity are the production of intestinal attaching and effacing (AE) lesions (11) and the secretion of potent Shiga toxins, which are responsible for the HUS (10). Most of the EHEC genetic elements responsible for the AE lesions are contained within the pathogenicity island called the ''locus of enterocyte effacement'' (LEE) (11).…”
mentioning
confidence: 99%
“…Enterohemorrhagic E. coli (EHEC) is known to cause disease in humans associated with diarrhea and hemorrhagic colitis. [39][40][41] EHEC serotype O157:H7 has emerged as a major cause of severe diarrhea worldwide and EHEC is the leading predecessor to pediatric acute renal failure in many countries. 42,43 Healthy ruminants are the principal reservoir of EHEC and human infections occur by ingestion of contaminated meat or dairy products contaminated with ruminant feces.…”
Section: Escherichia Colimentioning
confidence: 99%
“…Infection with EHEC may cause a variety of symptoms such as abdominal cramps, non-bloody diarrhoea and haemorrhagic colitis, which can progress to haemolytic-uraemic syndrome (HUS) (Karmali et al 1983). Among bacterial virulence factors that are involved in the pathogenesis of EHEC infections, Shiga toxin (stx) which is cytotoxic for Vero 4.2.…”
Section: Introductionmentioning
confidence: 99%