2005
DOI: 10.3168/jds.s0022-0302(05)72690-4
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Escherichia coli Strain Nissle 1917: Significant Reduction of Neonatal Calf Diarrhea

Abstract: Inappropriate daily use of antimicrobial drugs for the treatment of intestinal diseases is associated with an increased risk of antibiotic resistance. Thus, the establishment of new forms of therapy is still needed. Our objective was to examine the effect of the nonpathogenic Escherichia coli strain Nissle 1917 on the prophylaxis and treatment of neonatal calf diarrhea in a hypothesis-generating study (study I) and a subsequent confirmatory clinical study (study II) under field conditions. Both trials were des… Show more

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Cited by 73 publications
(45 citation statements)
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“…The mean incidence of diarrhea in individual herds of cattle can be as high as 80% (Cornaglia et al, 1992;Khan and Khan, 1995;Wright et al, 1995); therefore, rates of diarrhea > 50% are not unusual. The mortality rate due to diarrhea varies up to 25% (Khan and Khan, 1995;Buenau et al, 2005;Khan et al, 2009). Successful treatment of diarrheic calves based primarily on the use of broad-spectrum antibiotics or other antimicrobials along with administration of fluids and electrolytes for the correction of dehydration and acidemia (Roussel and Kasari, 1990;Berchtold, 1999;Senturk, 2003;Buenau et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The mean incidence of diarrhea in individual herds of cattle can be as high as 80% (Cornaglia et al, 1992;Khan and Khan, 1995;Wright et al, 1995); therefore, rates of diarrhea > 50% are not unusual. The mortality rate due to diarrhea varies up to 25% (Khan and Khan, 1995;Buenau et al, 2005;Khan et al, 2009). Successful treatment of diarrheic calves based primarily on the use of broad-spectrum antibiotics or other antimicrobials along with administration of fluids and electrolytes for the correction of dehydration and acidemia (Roussel and Kasari, 1990;Berchtold, 1999;Senturk, 2003;Buenau et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…The mortality rate due to diarrhea varies up to 25% (Khan and Khan, 1995;Buenau et al, 2005;Khan et al, 2009). Successful treatment of diarrheic calves based primarily on the use of broad-spectrum antibiotics or other antimicrobials along with administration of fluids and electrolytes for the correction of dehydration and acidemia (Roussel and Kasari, 1990;Berchtold, 1999;Senturk, 2003;Buenau et al, 2005). Therefore, intravenous administration of isotonic fluids is considered to be the best methods for treating severely dehydrated and acidotic calves with diarrhea (Simmons et al, 1985;Roussel and Kasari, 1990;Walker et al, 1998;Berchtold, 1999;Senturk, 2003).…”
Section: Introductionmentioning
confidence: 99%
“…A nonpathogenic strain has been well established in human medicine since 1917 [8] . This strain was used successfully under the brand name Mutaflor for treating various gut-related diseases, e.g., chronic constipation, ulcerative colitis, Crohn's disease, or pouchitis.…”
Section: Introductionmentioning
confidence: 99%
“…This strain was used successfully under the brand name Mutaflor for treating various gut-related diseases, e.g., chronic constipation, ulcerative colitis, Crohn's disease, or pouchitis. In addition, the strain prevented colonization of the intestine with microbial pathogens in new born infants [8] . In Germany, E. coli strain Nissle 1917 is authorized under the brand name Ponsocol for the prophylaxis of neonatal calf diarrhea and has been marketed since 2001.…”
Section: Introductionmentioning
confidence: 99%
“…Competition for iron is one mechanism by which Nissle inhibits Salmonella (42). Nissle is safe for use in animals and humans and has been shown to be effective in treating diarrhea, ulcerative colitis, and constipation and preventing necrotizing enterocolitis (NEC) in infants (44)(45)(46)(47).…”
mentioning
confidence: 99%