Escoliose degenerativa do adulto

Cristante, Alexandre Fogaça; Silva, Ricardo Teixeira e; Costa, Guilherme Henrique Ricardo da; Marcon, Raphael Martus

doi:10.1055/s-0040-1709736

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…The prevalence of ASD increases with age, reaching 32%-68% in people aged 65 years or over. 1,2 Spinal curvature progresses at 18-68 per year, 3 resulting in impaired lung function, reduced daily activity, and increased mortality. 4 Since pain is often only partially relieved by postural compensation and patients are unable to self-manage, ASD often progresses to a point where surgical treatment is necessary.…”

Section: Introductionmentioning

confidence: 99%

Self-management in patients with adult spinal deformity: a best practice implementation project

Zhang,

Liu,

Shi

et al. 2024

JBI Evidence Implementation

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Introduction: The prevalence of adult spinal deformity (ASD) has increased in recent years. Patients often have to live for a prolonged period from the onset of the condition, up until the need for surgical treatment. Self-management plays a crucial role in disease progression and prognosis. Objectives: This project aimed to promote evidence-based practices for the self-management of patients with ASD. Methods: This project was guided by the JBI Evidence Implementation Framework project and was conducted in the orthopedic department of a tertiary care hospital in China. A baseline audit was conducted to evaluate current practice against best practice recommendations. Barriers were identified and, after the implementation of improvement strategies, a follow-up audit was conducted to assess project effectiveness. Results: A comparison between the baseline and follow-up audits revealed a significant increase in nurses’ compliance with best practices (rising from 0%–64% to 97.7%–100%) in the following areas: improved health promotion behaviors by nurses in self-management of ASD patients; acquisition and application of communication skills with patients; increased availability of educational materials in the ward; and establishment of conservative treatment follow-up instructions for patients. For patients, the Visual Analog Scale of pain decreased from (2.72 ± 1.67) to (1.90 ± 1.14), the Oswestry Disability Index decreased from (49.96 ± 16.49) to (39.83 ± 18.97), self-management behaviors improved from (10.84 ± 4.31) to (19.52 ± 6.31), and maximum isometric muscle strength in the standing position increased from (179.48 ± 91.18)N to (250.03 ± 91.50)N, all with statistically significant improvements (p <0.05). For nurses, the knowledge questionnaire score improved from (34.83 ± 24.16) to (82.00 ± 11.11) (p <0.05). Conclusions: This project helped ASD patients improve self-management, alleviated their clinical symptoms, and improved nurses’ knowledge of best practices. Future audits will be conducted to review long-term project outcomes. Spanish abstract: http://links.lww.com/IJEBH/A193

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Section: Introductionmentioning

confidence: 99%

Self-management in patients with adult spinal deformity: a best practice implementation project

Zhang,

Liu,

Shi

et al. 2024

JBI Evidence Implementation

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“…The intervertebral disc (IVD) consists of a soft central nucleus pulposus, a tough annulus fibrosus, and a hyaline cartilage endplate, which acts as a shock absorber in the spine and allows for spinal motion. Studies have demonstrated that with aging, changes such as an increase in protease activity and a decrease in proteoglycan synthesis led to a reduction in the height and mechanical properties of the IVD, which contributed to the onset and development of ADS [ 7 ]. In turn, ADS can further aggravate IVDD [ 8 ], which forms a vicious circle.…”

Section: Introductionmentioning

confidence: 99%

Overloaded axial stress activates the Wnt/β-Catenin pathway in nucleus pulposus cells of adult degenerative scoliosis combined with intervertebral disc degeneration

Cai¹,

Luo²,

Xi³

et al. 2023

Mol Biol Rep

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Background Intervertebral disc degeneration (IVDD) is the initiating factor of adult degenerative scoliosis (ADS), and ADS further accelerates IVDD, creating a vicious cycle. Nevertheless, the role of the Wnt/β-Catenin pathway in ADS combined with IVDD (ADS-IVDD) remains a mystery. Accordingly, this study was proposed to investigate the effect of axial stress on the Wnt/β-Catenin pathway in nucleus pulposus cells (NPCs) isolated from DS-IVDD patients. Methods Normal NPCs (N-NPC) were purchased and the NPCs of young (25–30 years; Y-NPC) and old (65–70 years; O-NPC) from ADS-IVDD patients were primary cultured. After treatment of NPC with overloaded axial pressure, CCK-8 and Annexin V-FITC kits were applied for detecting proliferation and apoptosis of N-NPC, Y-NPC and O-NPC, and western blotting was performed to assess the expression of Wnt 3a, β-Catenin, NPC markers and apoptosis markers (Bax, Bcl2 and Caspase 3). Results N-NPC, Y-NPC and O-NPC were mainly oval, polygonal and spindle-shaped with pseudopods, and the cell morphology tended to be flattened with age. N-NPC, Y-NPC and O-NPC were capable of synthesizing proteoglycans and expressing the NPC markers (Collagen II and Aggrecan). Notably, the expression of Wnt 3a, β-Catenin, Collagen II and Aggrecan was reduced in N-NPC, Y-NPC and O-NPC in that order. After overload axial stress treatment, cell viability of N-NPC and Y-NPC was significantly reduced, and the percentage of apoptosis and expression of Wnt 3a and β-Catenin were significantly increased. Conclusions Overloaded axial pressure activates the Wnt/β-Catenin pathway to suppress proliferation and facilitate apoptosis of NPC in ADS-IVDD patients.

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L1-pelvic angle: a convenient measurement to attain optimal deformity correction

Chanbour,

Waddell,

Vickery

et al. 2023

Eur Spine J

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Escoliose degenerativa do adulto

Cited by 4 publications

References 33 publications

Self-management in patients with adult spinal deformity: a best practice implementation project

Self-management in patients with adult spinal deformity: a best practice implementation project

Overloaded axial stress activates the Wnt/β-Catenin pathway in nucleus pulposus cells of adult degenerative scoliosis combined with intervertebral disc degeneration

L1-pelvic angle: a convenient measurement to attain optimal deformity correction

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