Escore eletrocardiográfico: aplicação em ergometria para avaliação do precondicionamento isquêmico

Uchida, Augusto Hiroshi; Moffa, Paulo Jorge; Hueb, Whady; Cesar, Luiz Antônio Machado; Ferreira, Beatriz Moreira Ayub; Ramires, José Antônio Franchini

doi:10.1590/s0066-782x2010005000122

Cited by 4 publications

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“…The parameters that will be used to evaluate IP will be: T-1.0 mm and RPP. An improvement of at least 30 s in T-1.0 mm between the two sequential tests will be used to consider IP present, as previously described [11]. In the case of an improvement less than 30 s, an improvement in RPP will also be used to indicate the presence of IP.…”

Section: Methodsmentioning

confidence: 99%

“…During these tests, ischemic parameters like the time to develop 1.0 mm ST depression in an electrocardiogram print-out, the time to develop angina, the morphology of ST depression, the total exercise time and the double-product at the time of 1.0 mm ST-depression are registered in these two sequential tests and compared [9]. Patients are considered to present ischemic preconditioning if they improve ischemic parameters in the second of two tests [9,11]. The most widely accepted parameter to consider the presence of IP is the improvement in the time to 1.0 mm ST depression [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…Patients are considered to present ischemic preconditioning if they improve ischemic parameters in the second of two tests [9,11]. The most widely accepted parameter to consider the presence of IP is the improvement in the time to 1.0 mm ST depression [11,12]. …”

Section: Introductionmentioning

confidence: 99%

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Hypotheses, rationale, design, and methods for evaluation of ischemic preconditioning assessed by sequential exercise tests in diabetic and non-diabetic patients with stable coronary artery disease – a prospective study

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Garcia

Uchida

et al. 2013

BMC Cardiovasc Disord

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BackgroundIschemic preconditioning is a powerful mechanism of myocardial protection and in humans it can be evaluated by sequential exercise tests. Coronary Artery Disease in the presence of diabetes mellitus may be associated with worse outcomes. In addition, some studies have shown that diabetes interferes negatively with the development of ischemic preconditioning. However, it is still unknown whether diabetes may influence the expression of ischemic preconditioning in patients with stable multivessel coronary artery disease.Methods/DesignThis study will include 140 diabetic and non-diabetic patients with chronic, stable coronary artery disease and preserved left ventricular systolic function. The patients will be submitted to two sequential exercise tests with 30-minutes interval between them. Ischemic parameters will be compared between diabetic and non-diabetic patients. Ischemic preconditioning will be considered present when time to 1.0 mm ST-segment deviation is greater in the second of two sequential exercise tests. Exercise tests will be analyzed by two independent cardiologists.DiscussionIschemic preconditioning was first demonstrated by Murry et al. in dog’s hearts. Its work was reproduced by other authors, clearly demonstrating that brief periods of myocardial ischemia followed by reperfusion triggers cardioprotective mechanisms against subsequent and severe ischemia. On the other hand, the demonstration of ischemic preconditioning in humans requires the presence of clinical symptoms or physiological changes difficult to be measured. One methodology largely accepted are the sequential exercise tests, in which, the improvement in the time to 1.0 mm ST depression in the second of two sequential tests is considered manifestation of ischemic preconditioning.Diabetes is an important and independent determinant of clinical prognosis. It's a major risk factor for coronary artery disease. Furthermore, the association of diabetes with stable coronary artery disease imposes worse prognosis, irrespective of treatment strategy. It’s still not clearly known the mechanisms responsible by these worse outcomes. Impairment in the mechanisms of ischemic preconditioning may be one major cause of this worse prognosis, but, in the clinical setting, this is not known.The present study aims to evaluate how diabetes mellitus interferes with ischemic preconditioning in patients with stable, multivessel coronary artery disease and preserved systolic ventricular function.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hypotheses, rationale, design, and methods for evaluation of ischemic preconditioning assessed by sequential exercise tests in diabetic and non-diabetic patients with stable coronary artery disease – a prospective study

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Garcia

Uchida

et al. 2013

BMC Cardiovasc Disord

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“…For ergospirometric evaluation, an interdisciplinary low chart from Obesity and Bariatric Surgery´s Program was followed, through previous medical approach and subsequent release for test, which was attended by a cardiologist that analyzed electrocardiographic records by an electrocardiograph from TEB ECGPC of twelve derivations with positioning proposed by Mason and Likar [20]. The room was prepared to guarantee calorimeter´s recommendations, from CAREFUSION, mode VMax 29N Encore, those are, minimum noise ambient and not more than three evaluators, with temperature ranging from 20 to 24 degrees and humidity between 50 and 60%.…”

Section: Instruments and Proceduresmentioning

confidence: 99%

Study of body composition, physiological variables in Grade III obese submitted to arm ergometer test

Linhares¹

2017

New Insights Obes Gene Beyond

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Introduction: Number of obese people is growing on a daily basis in Brazil, including morbid obese ones, but there is still a lack of studies with this subject. Due to this, the main goal of this study was to identify body profi le, physiological variables behavior and oxygen consumption in grade III obese women, submitted to an ergospirometric test in arm ergometer. Method: Take part in this study, thirteen (13) female grade III obese patients between 20 and 40 years. They were submitted to an electric bioimpedance test for body composition measurement and an Ergospirometric test in arm ergometer for oxygen consumption, heart rate, and oxygen saturation, systolic and diastolic arterial pressure, resting and after exercises, analysis. Results: The patients revealed a BMI of 46.5±3.81 kg/m², 51.9±1.59% of body fat percentage. The patients reached 168.2±4.57bpm of heart rate, didn't make any hypertensive response to the effort reaching an arterial pressure of 171.1±22.15mmHg x 87.5±4.18mmHg. Oxygen saturation was 98±0.71% and oxygen consumption peak was, also in average, 12.3±2.75ml.kg.min-1. Conclusion: It was verifi ed that there was no oxygen saturation drop nor hypertensive response and all of the patients reached the maximum heart rate.

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Comparação entre o teste ergométrico e a cintilografia miocárdica na avaliação do precondicionamento isquémico precoce.

Buglia¹

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Escore eletrocardiográfico: aplicação em ergometria para avaliação do precondicionamento isquêmico

Abstract: Background: The time for 1.0 mm ST-segment depression (T-1.0 mm) adopted to characterize ischemic preconditioning (IPC) in sequential exercise tests is consistent and reproducible; however, it has several limitations.

Cited by 4 publications

References 31 publications

Hypotheses, rationale, design, and methods for evaluation of ischemic preconditioning assessed by sequential exercise tests in diabetic and non-diabetic patients with stable coronary artery disease – a prospective study

Hypotheses, rationale, design, and methods for evaluation of ischemic preconditioning assessed by sequential exercise tests in diabetic and non-diabetic patients with stable coronary artery disease – a prospective study

Study of body composition, physiological variables in Grade III obese submitted to arm ergometer test

Comparação entre o teste ergométrico e a cintilografia miocárdica na avaliação do precondicionamento isquémico precoce.

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