2006
DOI: 10.1016/j.jcrs.2006.02.021
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ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery

Abstract: Intracameral cefuroxime administered at the time of surgery significantly reduced the risk for developing endophthalmitis after cataract surgery.

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Cited by 388 publications
(172 citation statements)
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“…The study of 13 698 patients was terminated early and unmasked because the beneficial effect of cefuroxime was notably significant. 14 Intracameral cefuroxime significantly reduced the total risk of endophthalmitis, as well as proven infective endophthalmitis (P-values of 0.002 and 0.008, respectively). 14 The effect of intracameral antibiotics was not assessed in this study.…”
Section: Discussionmentioning
confidence: 89%
“…The study of 13 698 patients was terminated early and unmasked because the beneficial effect of cefuroxime was notably significant. 14 Intracameral cefuroxime significantly reduced the total risk of endophthalmitis, as well as proven infective endophthalmitis (P-values of 0.002 and 0.008, respectively). 14 The effect of intracameral antibiotics was not assessed in this study.…”
Section: Discussionmentioning
confidence: 89%
“…The incidence rate of endophthalmitis varies widely in different locations, and is influenced by the use of prophylactic measures [1]. In a recent study by the European Society of Cataract & Refractive Surgeons (ESCRS), intracameral injection of an antibiotic agent at the close of cataract surgery was reported to decrease the incidence of postoperative endophthalmitis by about 5-fold [2]. Although cefuroxime was used in this large multicenter study, other antibiotics are likely to be potentially useful agents, based on differences in the spectrum of antibacterial activity or for specific indications [3].…”
Section: Introductionmentioning
confidence: 99%
“…It was suggested that this treatment helps prevent bacterial POE by sterilizing the ocular surface and by penetrating the ocular tissues to provide intracameral antibiotic concentrations to eliminate bacteria that may enter the eye during surgical intervention. Recently, intracameral administration of cefuroxime at the time of surgery was shown to significantly reduce the risk of developing endophthalmitis after cataract surgery [20]. The EVS study[21]found that the most common pathogen isolated from clinical postoperative endophthalmitis cases was Staphylococcus epidermidis.…”
Section: Discussionmentioning
confidence: 99%