Esculetin inhibits proliferation, migration, and invasion of clear cell renal cell carcinoma cells

Duan, Junyao; Shi, Jing; Ma, Xin; Xuan, Yundong; Пин, Ли; Wang, Hanfeng; Yang, Fan; Gong, Huijie; Pang, Yuewen; Pang, Shaoqiang; Yan, Ye

doi:10.1016/j.biopha.2020.110031

Cited by 23 publications

(17 citation statements)

References 28 publications

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“…The results from our study suggested that AEL-sed showed reasonable anticancer effects. Several phytochemicals, such as diosmetin, esculetin, isoacteoside, baicalin, isoamericanol A, luteolin, apigenin, and genkwanin, among several others identified in the extract, have been reported as promising anticancer agents in several in vitro and in vivo studies [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. Therefore, A. ebracteatus extract contains several constituents with promising bioactivities that could be beneficial for the treatment of several disorders.…”

Section: Discussionmentioning

confidence: 99%

New Insights on Acanthus ebracteatus Vahl: UPLC-ESI-QTOF-MS Profile, Antioxidant, Antimicrobial and Anticancer Activities

et al. 2022

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This study investigated the antioxidant, antimicrobial, anticancer, and phytochemical profiling of extracts from the leaves and stem/root of Acanthus ebracteatus (AE). The total phenolic content (TPC), total flavonoid content (TFC), 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) radical-scavenging activity, 2, 2′-azino-Bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical-scavenging activity, metal chelating activities (MCA), ferric reducing antioxidant power (FRAP) and oxygen radical antioxidant capacity (ORAC) were used for antioxidant assessment. The ethanolic extracts of the leaves (AEL-nor) and stem/root (AEWP-nor) without chlorophyll removal and those with chlorophyll removal, using sedimentation process (AEL-sed and AEWP-sed), were prepared. Generally, AEL-sed showed the highest antioxidant activity (FRAP: 1113.2 µmol TE/g; ORAC: 11.52 µmol TE/g; MCA: 47.83 µmol EDTA/g; ABTS 67.73 µmol TE/g; DPPH 498.8 µmol TE/g; TPC: 140.50 mg/GAE g and TFC: 110.40 mg/CE g) compared with other extracts. Likewise, AEL-sed also showed the highest bacteriostatic (MIC) and bactericidal (MBC) effects, as well as the highest anticancer and antiproliferative activity against oral squamous carcinoma (CLS-354/WT) cells. UPLC-ESI-QTOF/MS analysis of AEL-sed and AEWP-sed tentatively identified several bioactive compounds in the extracts, including flavonoids, phenols, iridoids, and nucleosides. Our results provide a potentially valuable application for A. ebracteatus, especially in further exploration of the plant in oxidative stress-related disorders, as well as the application of the plant as potential nutraceuticals and cosmeceuticals.

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Section: Discussionmentioning

confidence: 99%

New Insights on Acanthus ebracteatus Vahl: UPLC-ESI-QTOF-MS Profile, Antioxidant, Antimicrobial and Anticancer Activities

et al. 2022

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“…Amygdalin extracted from Semen armeniacae Amarum inhibited cell adhesion, chemotactic activity and the invasion of ccRCC cells via the downregulation of integrin α5 and integrin α6, as well as suppression of integrin β1 to traffic to the plasma membrane, which has been shown to increase the metastatic potential of RCC cells [ 67 ]. Esculetin, extracted from Cortex fraxini , was shown to inhibit cell proliferation and block cell cycle progression, and to inhibit the migration of ccRCC cells by suppressing IGF-1/EGFR/PI3K/Akt pathway, downregulating the N-cadherin and vimentin, as well as upregulating the E-cadherin due to reversal of EMT activation [ 68 ]. Hsieh et al showed that fisetin, a natural flavonoid, inhibited invasion and migration in four different ccRCC cell lines in a dose-dependent manner through the downregulation of cyclin D1/E, cathepsin B, cathepsin S and cathepsin V accompanied with the increased phosphorylation of ERK [ 69 ].…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Potential of Natural Products in the Treatment of Renal Cell Carcinoma: A Review

et al. 2022

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Renal cell carcinoma (RCC) is a common cancer of the urinary system. The potential therapeutic effects of certain natural products against renal cell carcinoma have been reported both in vivo and in vitro, but no reviews have been published classifying and summarizing the mechanisms of action of various natural products. In this study, we used PubMed and Google Scholar to collect and screen the recent literature on natural products with anti-renal-cancer effects. The main mechanisms of action of these products include the induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis and reduction of drug resistance. In total, we examined more than 30 natural products, which include kahweol acetate, honokiol, englerin A and epigallocatechin-3-gallate, among others, have demonstrated a variety of anti-renal-cancer effects. In conclusion, natural products may have a wider application in kidney cancer than previously believed and are potential candidates for treatment in RCC.

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“…Esculetin was reported to prevent the proliferation, migration, and invasion of renal carcinoma cells by cell cycle arrest at G0/G1 and G2 phase, downregulating the expression of Cyclin D1, CDK4, CDK6, and c-Myc resulting in apoptosis. Levels of E-cadherin were increased whereas the expressions of N-Cadherin and vimentin were downregulated with esculetin treatment (Fig 1) [33].…”

Section: Esculetin In Cancermentioning

confidence: 86%

Mechanistic insights into the biochemical and pharmacological profile of esculetin

Garg¹,

Gupta²,

Sahu³

et al. 2022

Preprint

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Esculetin is a coumarin compound, which belongs to the class of benzopyrone enriched in various plants such as Sonchus grandifolius, Aesculus turbinata, and many others. Glycosides and caffeic acid conjugates are the common forms of esculetin present in medicinal plants. Esculetin acts as an antioxidant, anti-inflammatory, anti-diabetic, anti-hepatic, and anti-cancer agent by inhibiting the production of free radicals, inflammatory mediators, and genes that cause liver diseases and cancer. It also aids in the regulation of blood sugar. Scientists developing pharmaceutical formulations require some rationale and preliminary studies for drug design, but a small number of clinical studies on humans containing esculetin limit its potential for use as a safe alternative drug. Therefore, in this review article, the published studies have been reviewed to identify the pathogenesis of cancer, oxidative stress, inflammation, arthritis, diabetes and fatty liver along with the discussion on potential therapeutic strategies of esculetin. Advancements in our understanding of these diseases will aid in the development of new and innovative medications for treating many ailments. In conclusion, esculetin has immense potential to be used as a safe drug against many diseases but requires further testing and confirmation through clinical trials.

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Esculetin inhibits proliferation, migration, and invasion of clear cell renal cell carcinoma cells

Cited by 23 publications

References 28 publications

New Insights on Acanthus ebracteatus Vahl: UPLC-ESI-QTOF-MS Profile, Antioxidant, Antimicrobial and Anticancer Activities

New Insights on Acanthus ebracteatus Vahl: UPLC-ESI-QTOF-MS Profile, Antioxidant, Antimicrobial and Anticancer Activities

Therapeutic Potential of Natural Products in the Treatment of Renal Cell Carcinoma: A Review

Mechanistic insights into the biochemical and pharmacological profile of esculetin

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