ESE‐1 inhibits the invasion of oral squamous cell carcinoma in conjunction with MMP‐9 suppression

Abstract

These findings indicate that ESE-1 negatively regulates the invasion of oral SCC via transcriptional suppression of MMP-9.

Kaempferia pandurata Roxb. inhibits Porphyromonas gingivalis supernatant-induced matrix metalloproteinase-9 expression via signal transduction in human oral epidermoid cells

“…1A and 2A, it might be possible that Porphyromonas gingivalis supernatant induced MMP-9 expression via activation of MAPK signaling pathways. Our results showed that MMP-9 was not expressed in unstimulated KB cells, which is in agreement with the results of Iwai et al (2008). These results are in-line with Chang et al (2002aChang et al ( , 2004, who demonstrated that MMP-9 expression was also elevated by Porphyromonas gingivalis supernatant in human periodontal ligament fibroblasts and osteosarcoma cells in vitro.…”

Effects of Panduratin A Isolated from Kaempferia pandurata ROXB. on the Expression of Matrix Metalloproteinase-9 by Porphyromonas gingivalis Supernatant-Induced KB Cells

“…Our results were similar to a previous study demonstrating that MMP-9 expression was also elevated by P. gingivalis supernatant in human epithelial cells and human osteosarcoma cells. 7,27) In addition, we observed that MMP-9 was not detectable in unstimulated KB cells, which is in agreement with the results of Iwai et al 28) Therefore, P. gingivalis supernatant was added to KB cultures to stimulate MMP-9 secretion. Among several virulence factors in P. gingivalis supernatant, gingipains and lipopolysaccharides have been reported to enhance MMP-9 secretion from human oral epithelial cell models.…”

Loss of ELF3 immunoexpression is useful for detecting oral squamous cell carcinoma but not for distinguishing between grades of epithelial dysplasia

“…Studies in-vitro and in-vivo have associated ELF3 expression with genotypes and phenotypes that underlie and characterize epithelial to mesenchymal transformation [27,28]. Suppression of ELF3 expression by Snail (a gene that is implicated in epithelial to mesenchymal transformation and strongly associated with head and neck squamous cell carcinoma [29][30][31]) may underlie the disagreement between the low immunostaining of ELF3 reported here, and the elevated expression of ELF3 reported for breast, pancreatic, and ovarian cancers [32][33][34], noting that in-situ hybridization localizes ELF3 RNA to the intermediate (non invasive) layer of OSCC [35].…”