Esketamine Combined with Dexmedetomidine to reduce Visceral Pain During elective Cesarean Section Under Combined Spinal-Epidural Anesthesia: A double-Blind Randomized Controlled Study

Yang, Ji-Rong; Li, Ying-Yuan; Ran, Tao-Jia; Lin, Xiao-Yu; Xu, Jin-Yan; Zhou, Shao-Li; Huang, Pin-Jie

doi:10.2147/dddt.s460924

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2024

2025

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Effect of esketamine on reducing postpartum pain and depression

Lucke-Wold,

Karamian

2025

World J Clin Cases

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In this editorial, we comment on a recent article by Chen et al , that addressed the effect of intraoperative injection of esketamine on postoperative analgesia and postoperative rehabilitation after cesarean section. Poor management of post-cesarean pain is associated with decreased maternal care for the baby, longer hospitalization, and higher risk of developing postpartum depression. Esketamine is a more potent S-enantiomer of ketamine which has shown promising analgesic and antidepressant properties for managing post-cesarean pain and depression in clinical studies. However, due to its potential adverse effects on the neurological and hemodynamic status of patients, it is recommended that its usage in low doses should be limited to cesarean candidates experiencing unbearable pain. Before any recommendation for routine perioperative use of esketamine, more standardized clinical trials are needed to strengthen our existing knowledge of its effectiveness in reducing postpartum pain and depression.

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