Esketamine versus Sufentanil Applied Prior to Placement of Suspension Laryngoscope

Abstract

ObjectiveIn laryngeal microsurgery, the insertion of the suspension laryngoscope is a strong stimulus that may cause hemodynamic fluctuations and adverse cardiovascular events. The purpose of this study was to compare the effect of preemptive treatment with esketamine and sufentanil on maintaining hemodynamics and reducing the occurrence of adverse cardiovascular events during the insertion of suspension laryngoscope.MethodsIn this double‐blind randomized controlled trial, patients undergoing general anesthesia for laryngeal microsurgery were randomly assigned (1:1) to esketamine 0.5 mg kg−1 (esketamine group) and sufentanyl 0.125 μg kg−1 (sufentanil group) before inserting the laryngoscope, respectively.ResultsDuring the insertion of suspension laryngoscope, the incidence of bradycardia (HR < 60 beats/min) was 39.3% (22/56) in esketamine group, lower than 60.0% (33/55) in sufentanil group (odds ratio [OR], 2.32 [95% CI, 1.11–5.08]; p = 0.029). The incidence of hypotension (MAP <65 mmHg) was 33.9% (19/56) in esketamine group, lower than 56.4% (31/55) in sufentanil group (odds ratio [OR], 2.52 [95% CI, 1.91–5.27]; p = 0.018). The frequency of hypotension in esketamine group was lower than that in sufentanil group (0.36 ± 0.52 vs. 0.56 ± 0.50, p = 0.035). The time‐weighted average of HR dropping above 30% of baseline was smaller in esketamine group than in sufentanil group (0.52 ± 2.06 vs. 1.08 ± 2.77, p = 0.006).ConclusionsThese findings showed that compared with preemptive treatment of sufentanil (0.125 μg kg−1), esketamine (0.5 mg kg−1) was effective in reducing the incidence of cardiovascular adverse events, including bradycardia and hypotension induced by the insertion of suspension laryngoscope during the laryngeal microsurgery.Level of Evidence2 Laryngoscope, 2023

The effects of esketamine on blood pressure and hypotension incidence during induction of bariatric surgery: A randomized controlled trial

“…[ 14 , 15 ] Previous studies observed that this effect of esketamine can be used to improve hemodynamic stability in patients undergoing procedures under general anesthesia. [ 15 – 22 ] In light of the evidence from previous studies, we hypothesize that esketamine may improve blood pressure during the induction phase of the procedure since it stimulates the sympathetic nervous system, making it an ideal drug for the induction of anesthesia in unstable patients. [ 23 , 24 ]…”