Introduction: Employee health was assured by regulation no. 27897 on 6 April 2011, in our country, Turkey. Health workers are periodically examined and controlled according to the risk in their duties. In this study, we aimed to analyze periodic examinations of physicians working in an educational research hospital and determine the findings that may pose a risk for malignant diseases. Methods: Periodic health examination (PHE) files of 227 physicians working in Haydarpaşa Numune Training and Research Hospital between 01.06.2018-31.12.2018 were examined in this study. Results: The files of 227 physicians who gave consent for the periodic examination were studied. Of the 221 physicians whose data were complete, 125 were female (56.6%), and 96 were male (43.4%). When smoking was questioned regarding the etiology of malignancy, the number of physicians smoking was 32 (14.1%), and no statistically significant difference was found between the genders. When another risk factor obesity rates were examined, 20.7% were overweighed (n: 47), 3.5% were obese (n: 8), and 0.4% were morbidly obese (n: 1). Male physicians were more likely to be overweighed or obese, and the difference was statistically significant compared to women. The rates of other findings that may be risk factors were much lower. Discussion and Conclusion: When PHE files are analyzed regarding risk factors that may be involved in the etiology of malignancy in the literature, it is concluded that physicians have positive results according to the data of the world and our country.