Esmolol hydrochloride: An ultrashort-acting, β-adrenergic blocking agent

Angaran, David M.; Schultz, Nathan J.; Tschida, Victor H.

doi:10.1093/ajhp/43.5.1322

Cited by 26 publications

(21 citation statements)

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“…Esmolol, on the other hand, is a very short-acting ␤-blocker that decreases heart rate, Hypertensive Crisis myocardial contractility, and cardiac output. 52 It can be used cautiously in patients with an acute MI concomitantly with nitroglycerin. Nicardipine is a dihydropyridine derivative calcium channel blocker with cerebral and coronary vasodilatory activity.…”

Section: Management/treatmentmentioning

confidence: 99%

Hypertensive Crisis

Rodriguez

Kumar

2010

Cardiology in Review

140

116

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Hypertension is a common chronic medical condition affecting over 65 million Americans. Uncontrolled hypertension can progress to a hypertensive crisis defined as a systolic blood pressure >180 mm Hg or a diastolic blood pressure >120 mm Hg. Hypertensive crisis can be further classified as a hypertensive urgency or hypertensive emergency depending on end-organ involvement including cardiac, renal, and neurologic injury. The prompt recognition of a hypertensive emergency with the appropriate diagnostic tests and triage will lead to the adequate reduction of blood pressure, ameliorating the incidence of fatal outcomes. Severely hypertensive patients with acute end-organ damage (hypertensive emergencies) warrant admission to an intensive care unit for immediate reduction of blood pressure with a short-acting titratable intravenous antihypertensive medication. Hypertensive urgencies (severe hypertension with no or minimal end-organ damage) may in general be treated with oral antihypertensives as an outpatient. Rapid and short-lived intravenous medications commonly used are labetalol, esmolol, fenoldopam, nicardipine, sodium nitroprusside, and clevidipine. Medications such as hydralazine, immediate release nifedipine, and nitroglycerin should be avoided. Sodium nitroprusside should be used with caution because of its toxicity. The risk factors and prognosticators of a hypertensive crisis are still under recognized. Physicians should perform complete evaluations in patients who present with a hypertensive crisis to effectively reverse, intervene, and correct the underlying trigger, as well as improve long-term outcomes after the episode.

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Section: Management/treatmentmentioning

confidence: 99%

Hypertensive Crisis

Rodriguez

Kumar

2010

Cardiology in Review

140

116

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“…13 The large reductions in heart rate and blood pressure confirm that beta blockade can be achieved with a 3O-min infusion. Specifically, its rapid onset of action and ultrashort half life (9 min) allows for a rapid dose titration which permits more complete beta blockade than can be achieved acutely with other intravenous agents.…”

Section: Response To Esmololmentioning

confidence: 83%

“…13 This trial was designed to determine whether cardioselective beta blockade could be safely achieved in predominantly hospitalized, acutely ill patients with COPD. Esmolol is a cardioselective agent with a rapid onset ofaction and an ultrashort halflife (9 min), allowing more complete beta blockade during a titrated short-term infusion.…”

mentioning

confidence: 99%

Esmolol and Ventilatory Function in Cardiac Patients with COPD* *Cardiac and Critical Care Units, Massachusetts General Hospital, Boston.

Gold

Dec

Cocca-Spofford

et al. 1991

Chest

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“…ESM may produce systolic hypotension as a side effect, but this is usually seen in high doses. The most common side effects associated with the use of ESM are hypotension, confusion, bradycardia and phlebitis . Therefore, it is important to develop a sensitive method that could detect ESM precisely and rapidly in biological fluids and pharmaceutical preparations.…”

Section: Introductionmentioning

confidence: 99%

Development of a Surfactant/Platinum Composite for Sensitive Cardio‐selective Beta Blocker Detection and their Theoretical Studies

et al. 2019

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An electrooxidative behavior of beta‐blocker drug esmolol was thoroughly investigated by using glassy carbon electrode modified with sodium dodecyl sulfate‐based platinum nanoparticles. The designed nanosensor exhibited remarkable electro‐catalytic effect by dramatically boosting the signal of the esmolol as compared to the bare electrode with detection limit up to picomolar. The effects of pH, scan rate, temperature, deposition potential, deposition time, effect of electrolyte and interfering agents were investigated to optimize conditions for getting intense signal of the analyte. Under optimized experimental conditions, a linear calibration plot for esmolol with a detection limit of 60 pM was obtained. The analyte sensing ability of the modified electrode was supported by the application of theoretical studies that showed favorable interaction between sodium dodecyl sulfate/platinum nanoparticles composite and esmolol. In this study, our aim was to developed a nanosensor for the sensitive detection of esmolol by electrochemical assay. We tried a lot of different modification style and modifiers for creating a sensitive nanosensor for esmolol. This nanosensor can be applied to the esmolol in serum sample without using any further separation, evaporation or precipitation steps. Application could apply in serum sample to test accuracy of our sensor and method. The high recovery results were observed in serum study.

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Esmolol hydrochloride: An ultrashort-acting, β-adrenergic blocking agent

Cited by 26 publications

References 0 publications

Hypertensive Crisis

Hypertensive Crisis

Esmolol and Ventilatory Function in Cardiac Patients with COPD* *Cardiac and Critical Care Units, Massachusetts General Hospital, Boston.

Development of a Surfactant/Platinum Composite for Sensitive Cardio‐selective Beta Blocker Detection and their Theoretical Studies

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