Esofagites em pacientes com síndrome de imunodeficiência adquirida: estudo histológico e imunoistoquímico

Vidal, Ana Paula Aguiar; Pannain, Vera Lúcia; Bottino, Adriana

doi:10.1590/s0004-28032007000400006

Cited by 7 publications

(3 citation statements)

References 38 publications

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“…The diagnosis of this condition is usually suggested at upper digestive endoscopy in the presence of white patches on erythematous oesophageal mucosa Confirmatory biopsies after gram staining indicate the presence of mycelial filaments and pseudo hyphae with invasion of mucosal cells. In addition, culture makes it possible to identify the type of mycosis, which is most often Candida albicans [16] [17]. These examinations were not carried out in our patients.…”

Section: Discussionmentioning

confidence: 97%

Oesophageal Mycosis: Epidemiological and Clinical Aspects and Risk Factors for Occurrence in the Digestive Endoscopy Unit of the Donka National Hospital, Conakry CHU

Sarifou,

Oumarou,

Abdoulatif

et al. 2024

OJGas

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Introduction: Oesophageal mycosis (OM) is one of the most common opportunistic infections in patients infected with HIV (Human Immunodeficiency Virus). However, this condition is increasingly observed in immunocompetent subjects. The aim of this study was to determine the endoscopic prevalence, clinical characteristics and risk factors for the occurrence of oesophageal mycosis in our department. Patients and Method: This was a prospective cross-sectional study of all patients who underwent oeso-gastroduodenal fibroscopy during the period from 1 st January to 31 st

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Section: Discussionmentioning

confidence: 97%

Oesophageal Mycosis: Epidemiological and Clinical Aspects and Risk Factors for Occurrence in the Digestive Endoscopy Unit of the Donka National Hospital, Conakry CHU

Sarifou,

Oumarou,

Abdoulatif

et al. 2024

OJGas

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“…No entanto, 15% dos pacientes com SK visceral não apresentam envolvimento cutâneo. 5 Estudo realizado por Friedman SL 14 , também relata que o envolvimento do trato gastrointestinal pelo sarcoma de Kaposi pode preceder ou ser sincrônico com o desenvolvimento de lesões cutâneas ou pode ocorrer sem lesões cutâneas e, o envolvimento gastrointestinal ocorre no momento do diagnóstico em 40% dos homens homossexuais com AIDS e é visto em até 80% em autópsias.…”

Section: Discussionunclassified

Dispepsia funcional como manifestação inicial em Sarcoma de Kaposi Gástrico

De Souza,

Pinto

2023

Braz. J. Hea. Rev.

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O sarcoma de Kaposi é um tumor vascular de baixo grau de origem endotelial que está comumente associado ao HIV, tendo a infecção por HHV8 como um dos fatores responsáveis pelo seu desenvolvimento. É classificado em quatro grupos: clássico, endêmico (africano), iatrogênico (associado a transplantes) e epidêmica (associada ao Vírus da Imunodeficiência Humana (HIV/AIDS). O presente relato objetiva apresentar o caso de um paciente jovem com diagnóstico de sarcoma de Kaposi associado ao HIV. O caso em questão trata-se de um paciente masculino, 25 anos, homoafetivo, com história de epigastralgia e saciedade e plenitude pós-prandial há quatro meses, sem associação com lesões cutâneas e outras queixas, não responsivo à terapia medicamentosa. A sorologia era positiva para o vírus HIV. Foi submetido a exames que diagnosticaram sarcoma de Kaposi do tubo digestivo além de estudo imuno-histoquimico revelou expressão para CD31, além de expressão nuclear para HHV8. O sarcoma de Kaposi possui acometimento multifocal, especialmente da pele e do trato gastrointestinal, estando relacionada principalmente à síndrome da imunodeficiência adquirida. A extensão e a agressividade dos tumores SK dependem da epidemiologia e imunidade do hospedeiro. Representa 60% dos tumores que se desenvolvem em pacientes com HIV/AIDS e também é a neoplasia intra-abdominal mais frequente neles.

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“…3 The viral agents most frequently associated with esophageal ulcers (EU) in HIV-infected patients are cytomegalovirus (CMV) and herpes simplex virus (HSV). 4,5 Upper gastrointestinal (UGI) endoscopy with biopsies is fundamental for the diagnosis of EU in patients with AIDS, 6,7 although there is controversy about whether the routine histologic method based on hematoxylin-eosin (HE) staining is sufficient for the etiologic characterization of the process or whether there is the need to use immunohistochemistry (IH) as a complement to HE.…”

Section: Introductionmentioning

confidence: 99%

Esophageal Ulcer in Brazilian Patients with HIV: Prevalence and Comparative Analysis Among Diagnostic Methods

Brunaldi

Rezende

Garcia

et al. 2010

AIDS Patient Care and STDs

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Esophageal ulcer (EU) represents an important comorbidity in AIDS. We evaluated the prevalence of EU, the accuracy of the endoscopic and histologic methods used to investigate viral EU in HIV-positive Brazilian patients and the numerical relevance of tissue sampling. A total of 399 HIV-positive patients underwent upper gastrointestinal (UGI) endoscopy. HIV-positive patients with EU determined by UGI endoscopy followed by biopsies were analyzed by the hematoxylin-eosin (HE) and immunohistochemical (IH) methods. EU was detected in 41 patients (mean age, 39.2 years; 23 males), with a prevalence of 10.27%. The median CD4 count was 49 cells/mm(3) (range, 1-361 cells/mm(3)) and the viral load was 58,869 copies per milliliter (range, 50-77,3290 copies per milliliter). UGI endoscopy detected 29 of 41 EU suggestive of cytomegalovirus (CMV) infection and 7 of 41 indicating herpes simplex virus (HSV) infection. HE histology confirmed 4 of 29 ulcers induced by CMV, 2 of 7 induced by HSV, and 1 of 7 induced by HSV plus CMV. IH for CMV and HSV confirmed the HE findings and detected one additional CMV-induced case. UGI endoscopy showed 100% sensitivity and 15% specificity for the diagnosis of EU due to CMV or HSV compared to HE and IH. HE proved to be an adequate method for etiologic evaluation, with 87% sensitivity and 100% specificity compared to IH. The number of samples did not influence the etiologic evaluation. The data support the importance of IH as a complementary method for HE in the diagnosis of EU of viral etiology.

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Esofagites em pacientes com síndrome de imunodeficiência adquirida: estudo histológico e imunoistoquímico

Cited by 7 publications

References 38 publications

Oesophageal Mycosis: Epidemiological and Clinical Aspects and Risk Factors for Occurrence in the Digestive Endoscopy Unit of the Donka National Hospital, Conakry CHU

Oesophageal Mycosis: Epidemiological and Clinical Aspects and Risk Factors for Occurrence in the Digestive Endoscopy Unit of the Donka National Hospital, Conakry CHU

Dispepsia funcional como manifestação inicial em Sarcoma de Kaposi Gástrico

Esophageal Ulcer in Brazilian Patients with HIV: Prevalence and Comparative Analysis Among Diagnostic Methods

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