Esomeprazole‐induced ashy dermatosis‐like drug eruptions

Osimertinib-associated ashy dermatosis–like hyperpigmentation

“…This time interval is compatible with the reported drug-induced AD latency period of 2 to 12 months. 9 Because of its asymptomatic nature, cosmesis is the primary concern in patients affected by AD. In adults, lesions tend to persist, and no criterion standard treatment is currently available.…”

A case of generalized lichen planus pigmentosus: an atypical clinical variety

“…The present patient had no history of suspicious or doubtful medication before the onset and the brown macules are quite atypical to post-inflammatory hyperpigmentation. Clinically, ashy dermatosis is more often observed as disseminated macules initially with an asymptomatic active elevated red border and has a chronic course, lacking a well-defined histopathologic feature [ 2 ]. In the current patient, the eruptions were asymmetrically diffused over the trunk and flexures, suggesting LPP and not ashy dermatosis.…”

Dermatologic adverse reactions to proton‐pump inhibitors: A synthetized review

“…Erythema dyschromicum perstans (EDP), also called ashy dermatosis, is an uncommon, slowly progressive dermatosis characterized by ash gray hyperpigmented macules of variable size and shape symmetrically distributed over the neck, trunk and proximal arms. 6 cases of EDP have been described so far; 4 cases following the use of omeprazole, 49,50 1 case with esomeprazole 51 and 1 case with lansoprazole 52 . The latency between drug initiation and onset of the skin rash ranged between 2 to 12 months.…”