Esophageal achalasia secondary to mesothelioma

Goldschmiedt, Markus; Peterson, Walter L.; Spielberger, Ricardo; Lee, Edward L.; Kurtz, Stanley F.; Feldman, Mark

doi:10.1007/bf01537280

Cited by 17 publications

(1 citation statement)

References 27 publications

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“…Pleural mesothelioma is a rare cause of malignant pseudoachalasia, accounting for 7.5% of all diagnoses [3] . Goldschmiedt et al [18] reported of a 64-year-old male presenting with progressive dysphagia and radiological and manometric findings sug gestive of achalasia. Thoracentesis and pleural biopsy were performed for a left pleural effusion and no malignant cells were found.…”

Section: Discussionmentioning

confidence: 98%

Laparoscopic diagnosis of pleural mesothelioma presenting with pseudoachalasia

Saino¹,

Bona²,

Nencioni³

et al. 2009

WJG

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Pseudoachalasia due to pleural mesothelioma is an extremely rare condition. A 70-year-old woman presented with progressive dysphagia for solid and liquids and a mild weight loss. A barium swallow study revealed an esophageal dilatation and a smoothly narrowed esophagogastric junction. An esophageal manometry showed absence of peristalsis. Endoscopy demonstrated an extrinsic stenosis of the distal esophagus with negative biopsies. A marked thickening of the distal esophagus and a right-sided pleural effusion were evident at computed tomography (CT) scan, but cytological examination of the thoracic fluid was negative. Endoscopic ultrasound showed the disappearance of the distal esophageal wall stratification and thickening of the esophageal wall. The patient underwent an explorative laparoscopy. Biopsies of the esophageal muscle were consistent with the diagnosis of epithelioid type pleural mesothelioma. An esophageal stent was placed for palliation of dysphagia. The patient died four months after the diagnosis. This is the first reported case of pleural mesothelioma diagnosed through laparoscopy.

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Section: Discussionmentioning

confidence: 98%

Laparoscopic diagnosis of pleural mesothelioma presenting with pseudoachalasia

Saino¹,

Bona²,

Nencioni³

et al. 2009

WJG

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Achalasia

Richter¹,

Roberts²

2012

The Esophagus

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Epidemiology of hospitalization for achalasia in the United States

et al. 1993

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Achalasia is an uncommon esophageal motility disorder of unknown etiology. To gain insights into possible etiologic risk factors, demographic and comorbidity data were obtained from Medicare hospital discharge data files from 1986-1989 on patients aged 65 and older. Age-adjusted sex- and race-specific occurrence rates were calculated for each US state. The rate of comorbid illness occurrence in achalasia patients was compared to that of the entire hospitalized Medicare population. Records of 15,000 achalasia discharges were available for analysis. Achalasia discharge rates increased linearly from age 65 to 94 years. They were similar in males and females as well as whites and nonwhites. High rates were observed in the South and low rates in most states of the East North Central region around the Great Lakes and in the Pacific region. The same geographic pattern was observed in men and women as well as in the two separate subsets of data representing the periods 1986-1987 and 1988-1989. Achalasia was associated with a significantly increased risk for pulmonary complications, malnutrition, and gastroesophageal cancer. The concordant occurrence of achalasia in patients with Parkinson's disease, depressive disorder, and various other myoneural disorders indicated a possible etiologic relationship. Achalasia appears to represent the clinical end point of several different pathways. Besides aging, different neurologic diseases may contribute to a loss in control of esophageal motility. The geographic pattern could suggest the influence of environmental factors.

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Esophageal achalasia secondary to mesothelioma

Cited by 17 publications

References 27 publications

Laparoscopic diagnosis of pleural mesothelioma presenting with pseudoachalasia

Laparoscopic diagnosis of pleural mesothelioma presenting with pseudoachalasia

Achalasia

Epidemiology of hospitalization for achalasia in the United States

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