Esophageal Adenocarcinoma in a First Degree Relative Increases Risk for Esophageal Adenocarcinoma in Patients with Barrett's Esophagus

Systematic review with meta‐analysis: the effects of family history on the risk of Barrett's oesophagus and oesophageal adenocarcinoma

“…A significant higher pooled prevalence of familial OAC was found in the three studies 33,35,45 that confirmed the positive family history (10.0%; 95% CI: 6.4‐15.4; I 2 = 8%) compared with the four studies 32,36,37,40 with no confirmation of family history (2.5%; 95% CI: 1.6‐3.9; I 2 = 8%, P < 0.001). The prevalence for familial BO in the three studies that verified a positive family history 33,35,45 was also higher than in the three studies that did not verify family history 32,43,44 (10.6%; 95% CI: 3.7‐26.6; I 2 = 90% vs 7.3%; 95% CI: 5.6‐9.3; I 2 = 0%), but this difference was not statistically significant ( P = 0.48).…”

“…Nonetheless, one study including 26 OAC patients showed a significantly lower proportion of males in the familial OAC group, 44 whereas the remaining studies found no differences in gender between sporadic and familial BO/OAC. Two studies reported a lower age at BO or OAC diagnosis for patients with familial BO/OAC compared with sporadic BO (mean age: 58 vs 64 years) 32,44 . This was not found in three other studies 34,35,45 .…”

“…Agreement between investigators for assessment of study eligibility was good (kappa statistic = 0.79) 50 . Our final data set included 14 unique articles: 9 addressed prevalence of familial BO/OAC, 4 addressed prevalence of BO in first‐degree relatives and 7 addressed risk of having/developing BO or OAC 32‐45 …”

“…Nine studies including 1623 BO and 998 OAC patients assessed the prevalence of having at least one first‐degree relative with BO or oesophageal cancer 32,33,35‐37,40,43‐45 . A family history of BO or OAC was present in 1% to 10% of BO or OAC cases, except in one study, 33 in which a higher prevalence of familial BO (29%) and OAC (17%) was reported (Figure 2).…”

“…Of the 14 included articles, five studies addressed differences between patients with familial BO/OAC and sporadic cases 32,34,35,44,45 . No differences in ethnicity, smoking, alcohol consumption and obesity or body mass index were found.…”