Esophageal and Gastric Dysmotilities are Associated with Altered Glucose Homeostasis and Plasma Levels of Incretins and Leptin

Hammersjö, Rebecka; Roth, Bodil; Höglund, Peter; Ohlsson, Bodil

doi:10.1900/rds.2016.13.79

Cited by 8 publications

(7 citation statements)

References 36 publications

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“…This finding is in accordance with the work of Hammersjö et al [9] who showed autonomic neuropathy to be more common in women compared to men. Furthermore, the present results indicated no significant difference in dysphagia according to the type of diabetes mellitus.…”

Section: Discussionsupporting

confidence: 93%

Oropharyngeal Dysphagia and Diabetes Mellitus: Screening of 200 Type 1 and Type 2 Patients in Cairo, Egypt

Zakaria

Bekhet

Khodeir

et al. 2018

Folia Phoniatr Logop

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Background: Although diabetes mellitus is a well-researched systemic endocrinal disease, literature is scarce addressing the co-occurrence of oropharyngeal dysphagia with diabetes. Objective: The aim of this work was to screen Egyptian diabetic patients for symptoms suggestive of oropharyngeal dysphagia using the validated Arabic version of the Eating Assessment Tool (A-EAT-10). Participants and Methods: 200 Egyptian adult diabetic patients, aged from 18 to 59 years participated in the study. The inclusion criteria were being diabetic patients of type 1 or type 2. Patients were asked to complete the A-EAT-10 questionnaire. Results: Age progression and being female were found to be risk factors for dysphagia among diabetic patients participating in this study. The most common symptom among diabetic patients who complained of dysphagia was “I cough when I eat.” Conclusion: The present study suggests the presence of oropharyngeal swallowing problems among patients with diabetes mellitus.

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Section: Discussionsupporting

confidence: 93%

Oropharyngeal Dysphagia and Diabetes Mellitus: Screening of 200 Type 1 and Type 2 Patients in Cairo, Egypt

Zakaria

Bekhet

Khodeir

et al. 2018

Folia Phoniatr Logop

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“…Several research teams found a direct relationship between the rate of gastric emptying and postprandial serum glucose levels [ 6 , 7 , 48 , 49 ]. In patients with type 1 diabetes, altered rates of gastric emptying may impair efforts to adjust doses of prandial insulin according to the amounts of ingested nutrients.…”

Section: Glycemic Responses Induced By Fluctuations Of Gastric Empmentioning

confidence: 99%

“…In diabetic patients, gastric emptying may be either accelerated or delayed, with irregular intra- and interindividual fluctuations in the rate and clinical expression [ 4 , 5 ]. Gastric emptying also interacts with overall and postprandial glycemic control [ 6 , 7 ]. Therapeutic approaches aiming to correct both gastric emptying and variations of serum glucose levels include diet changes in meal sequence or content and incretin-based medications [ 8 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Bidirectional Relationship between Gastric Emptying and Plasma Glucose Control in Normoglycemic Individuals and Diabetic Patients

Mihai

Craiu

Cijevschi-Prelipcean

et al. 2018

Journal of Diabetes Research

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Gastric emptying and glycemic control pathways are closely interrelated processes. Gastric chyme is transferred into the duodenum with velocities depending on its solid or liquid state, as well as on its caloric and nutritional composition. Once nutrients enter the intestine, the secretion of incretins (hormonal products of intestinal cells) is stimulated. Among incretins, glucagon-like peptide-1 (GLP-1) has multiple glycemic-regulatory effects that include delayed gastric emptying, thus triggering a feedback loop lowering postprandial serum glucose levels. Glycemic values also influence gastric emptying; hyperglycemia slows it down, and hypoglycemia accelerates it, both limiting glycemic fluctuations. Disordered gastric emptying in diabetes mellitus is understood today as a complex pathophysiological condition, with both irreversible and reversible components and high intra- and interindividual variability of time span and clinical features. While limited delays may be useful for reducing postprandial hyperglycemias, severely hindered gastric emptying may be associated with higher glycemic variability and worsened long-term glycemic control. Therapeutic approaches for both gastric emptying and glycemic control include dietary modifications of meal structure or content and drugs acting as GLP-1 receptor agonists. In the foreseeable future, we will probably witness a wider range of dietary interventions and more incretin-based medications used for restoring both gastric emptying and glycemic levels to nearly physiological levels.

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“…Targeting the MLT receptor has therapeutic potential to treat hypomotility disorders, modulate hunger, and affect glucose metabolism [ 47 ]. The concentrations of GLP-1 [ 48 ] and 5-HT [ 49 ] were lower in diabetes patients with gastroparesis, and exogenous provision of 5-HT reversed delayed gastric emptying. Smiley, Smiley et al reported that the level of SP was significantly decreased in DGP rats [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Effects and Components of Herb Pair Huanglian-Banxia on Diabetic Gastroparesis by Network Pharmacology

Liang

Zhang

Jiang

et al. 2021

BioMed Research International

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Diabetic gastroparesis (DGP) is a serious and chronic complication of long-standing diabetes mellitus, which brings a heavy burden to individuals and society. Traditional Chinese medicine (TCM) is considered a complementary and alternative therapy for DGP patients. Huanglian (Coptidis Rhizoma, HL) and Banxia (Pinelliae Rhizoma, BX) combined as herb pair have been frequently used in TCM prescriptions, which can effectively treat DGP in China. In this article, a practical application of TCM network pharmacological approach was used for the research on herb pair HL-BX in the treatment of DGP. Firstly, twenty-seven potential active components of HL-BX were screened from the TCMSP database, and their potential targets were also retrieved. Then, the compound-target network and PPI network were constructed from predicted common targets, and several key targets were found based on the degree of the network. Next, GO and KEGG enrichment analyses were conducted to obtain several significantly enriched terms. Finally, the experimental verification was made. The results demonstrated that network pharmacological approach was a powerful means for identifying bioactive ingredients and mechanisms of action for TCM. Network pharmacology provided an effective strategy for TCM modern research.

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Esophageal and Gastric Dysmotilities are Associated with Altered Glucose Homeostasis and Plasma Levels of Incretins and Leptin

Cited by 8 publications

References 36 publications

Oropharyngeal Dysphagia and Diabetes Mellitus: Screening of 200 Type 1 and Type 2 Patients in Cairo, Egypt

Oropharyngeal Dysphagia and Diabetes Mellitus: Screening of 200 Type 1 and Type 2 Patients in Cairo, Egypt

Bidirectional Relationship between Gastric Emptying and Plasma Glucose Control in Normoglycemic Individuals and Diabetic Patients

Effects and Components of Herb Pair Huanglian-Banxia on Diabetic Gastroparesis by Network Pharmacology

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