Esophageal and Gastric Lesions in the Alcoholic

Wienbeck, M; Berges, W

doi:10.1007/978-3-642-70048-4_20

Cited by 12 publications

(7 citation statements)

References 64 publications

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“…the mucosal injury found in the majority of alcoholics [6][7][8]. In some studies an increased incidence of chronic gastritis in alcoholics has been dem onstrated [6,9] whereas other studies [8,10] did not reveal any evidence of alcohol play ing a role in the etiology of chronic gastritis.…”

mentioning

confidence: 99%

Effect of Alcohol Consumption on the Risk of <i>Helicobacter pylori </i>Infection

Höök‐Nikanne

1991

Digestion

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To investigate the effect of alcohol consumption on the risk of Helicobacter pylori infection, standardized questionnaires on drinking habits were used to interview 451 patients, whose H. pylori status was determined both by culture and serology. Reported alcohol consumption did not increase the risk of H. pylori infection (a 1.0 odds ratio, CI₉₅ 0.6–1.6). However, when the patients were divided into two age-groups, those under 35 years who reported to use alcohol seemed to have a slightly higher risk of H. pylori infection (a 3.3 odds ratio CI₉₅ 0.9–12.2) compared to those over 35 years (a 1.0 odds ratio, CI₉₅ 0.5–2.2). This phenomenon did not reach statistical significance. The type of alcohol consumed did not affect the age-adjusted risk of H. pylori infection. If pathologically defined chronic gastritis was found, the risk for H. pylori was high (a 26.7 odds ratio, CI₉₅ 12.1–59.0, for those under 35 years, and a 12.8 odds ratio, CI95 6.7–24.3, for those over 35 years of age).

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mentioning

confidence: 99%

Effect of Alcohol Consumption on the Risk of <i>Helicobacter pylori </i>Infection

Höök‐Nikanne

1991

Digestion

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“…These basic pathological conditions are malnutrition and obesity, fatty liver, alcoholic hepatitis, and liver cirrhosis (9-11), esophagitis (12), gastritis (13), enterocolitis (14), pancreatitis (15), liver cancer, cardiomyopathy (16), pulmonary infections (17,18), polyneuritis, myelitis, encephalitis and delirium tremens (19), some blood diseases (20), etc. Mortality in alcoholics is increased, although, according to other statistics, those who drink up to 35 g alcohol per day present lower mortality than those who do not drink at all.…”

Section: Addiction To Alcohol (Alcoholism)mentioning

confidence: 99%

The alcoholic lung disease: Historical background and clinical features

et al. 2007

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Summary. The purpose of this review article is to prove the damage that alcohol causes to the respiratory system. We will make a brief review of alcohols history in the course of the centuries till nowadays. The problem of addiction to alcohol (alcoholism) will be examined for several countries.Alcohol's metabolism is another topic to be discussed parallel to its pharmacological action. In addition, alcohol's impact on the respiratory system varies from damaging the mucociliary system to the regulation of breathing and from the sleep apnea syndrome to diffusion disorders. "Alcoholic lung disease" constitutes a syndrome despite the fact that the damage of the lung due to concurrent smoking and drug use is often indistinguishable.

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“…Dysfunction of oesophageal motility occurs secondary to alcohol, and this can lead to gastro-oesophageal reflux disease, oesophagitis, oesophageal ulcers and Barrett's oesophagus [27,28]. Oesophagitis occurs in about 40%, of chronic alcohol misusers whilst histological evidence of dysplasia has been reported at approximately 2% in men attending various gastroenterology clinics; a lower incidence rate for women is noted [29].…”

Section: Effects Of Alcohol On the Gastrointestinal Tractmentioning

confidence: 99%

Alcohol as a toxic and disease‐forming agent: Not just the liver and brain and not every drinker

Srirajaskanthan

Preedy

2007

Journal of Nutritional & Environmental Medicine

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Purpose: Excessive alcohol, defined as beyond the limits suggested by various government and statutory bodies, is damaging. This article aims to show that there may be as many as 120-200 adverse medical conditions and pathologies associated with alcohol misuse. Design and method: This review examines the different organ systems within the body and the effect of alcohol on nutrition, bone, skin, the gastrointestinal tract and skeletal muscle. Results: We identified that nearly all organ systems have the potential to be affected by alcohol or its ensuing metabolite acetaldehyde; as a result, the presence of two or more pathologies or conditions in alcohol misusers is not unusual. However, there are genetic factors that make individuals more susceptible to developing alcoholism and alcohol-related disease. These include genes for acetaldehyde formation and oxidation and possibly some neurotransmitters such as GABA, dopamine and 5-HT. For example, in simple terms, subjects with the dysfunctional ALDH2*2 allele which oxidises acetaldehyde less effectively than those with the ALDH2*1 allele generate high concentrations of acetaldehyde. This acts as a deterrent to alcoholism as acetaldehyde produces nausea and adverse cardiovascular symptoms. At the same time those with the ALDH2*2 allele who do consume alcohol have poorer outcome measures than those with the ALDH2*1 allele, due to the cytotoxic effects of acetaldehyde. Conclusions: Excessive ethanol consumption can lead to development of disease in many different organs, through its direct effect and also its toxic metabolites. However, not all individuals are susceptible and there are likely to be genetic as well as environmental factors that increase individuals' predisposition to develop alcohol related co-morbidity.Abbreviations: ADH: alcohol dehydrogenase, ALDH: aldehyde dehydrogenase, GABA: caminobutyric acid, 5-HT: serotonin

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Esophageal and Gastric Lesions in the Alcoholic

Cited by 12 publications

References 64 publications

Effect of Alcohol Consumption on the Risk of <i>Helicobacter pylori </i>Infection

Effect of Alcohol Consumption on the Risk of <i>Helicobacter pylori </i>Infection

The alcoholic lung disease: Historical background and clinical features

Alcohol as a toxic and disease‐forming agent: Not just the liver and brain and not every drinker

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