Esophageal atresia: Associated anomalies, mortality, and morbidity in Jordan

Abstract

Background: Esophageal atresia is a developmental disorder in which the upper and lower esophagus fail to connect. It has an estimated prevalence of 1 in 2,500-4,500 live births and has poorer outcomes in low-and middle-income countries than in high-income countries. This study focused on the disorder's epidemiology, morbidity, and mortality in Jordan to address the lack of data regarding esophageal atresia in this country. Methods: This was a retrospective study covering a 16-year period at a tertiary care academic hospital. Data were extracted from archived medical records and operative notes. All patients who had complete congenital esophageal atresia data were included. In total, the records of 55 patients were analyzed. Results: Of the included patients, 9% were diagnosed prenatally and 47% were diagnosed with polyhydramnios. The mean gestational age was 37 weeks, the mean birthweight was 2,550 g, and 60% of patients were male. Isolated cases of esophageal atresia were reported in 58.2% of patients. There was a high rate of associated congenital anomalies (41.8%), with cardiac lesions the most common (20%), and 5.5% were syndromic. Parental consanguinity was found in 18.2% of patients. Postoperative surgical-related morbidities included stricture (18/24; 75%) and leakage (5/24; 20.8%). Fistula recurrence occurred in one patient (4.2%). The mortality rate was 12.8%. Conclusion: Esophageal atresia causes a high rate of mortality and exhibits post-operative morbidities. Moreover, associated anomalies were frequently observed. A high level of the malformation was found among offspring from consanguineous marriages.

The effect of postoperative ventilation strategies on postoperative complications and outcomes in patients with esophageal atresia: Results from the Turkish Esophageal Atresia Registry

“…In addition, concomitant patient‐related risk factors such as prematurity and lung‐related respiratory tract problems may result in a respiratory support requirement. Although, it has been suggested that patients who had tensioned anastomosis, low birth weight or major accompanying anomalies were more likely to develop complications, we found no significant risk factor for necessitating IV mode in regression analysis 14 . Moreover, no clear relationship has been reported between anastomotic complications and respiratory support.…”

“…Although, it has been suggested that patients who had tensioned anastomosis, low birth weight or major accompanying anomalies were more likely to develop complications, we found no significant risk factor for necessitating IV mode in regression analysis. 14 Moreover, no clear relationship has been reported between anastomotic complications and respiratory support. It has been suggested that postoperative invasive and noninvasive respiratory support may either have a positive or negative effect on anastomosis.…”

Outcome of patients with esophageal atresia and tracheoesophageal fistula (Retrospective study)

“…While there was statistically significant difference between improved and died regarding GA( p value .019) , weight (p value . table (2).…”

Application value of high-frequency ultrasound combined with ultrasonography in the diagnosis of neonatal esophageal atresia

“…A study of 24 patients with EA found that low-frequency and high-frequency color Doppler ultrasonography was performed on the patients respectively. 79.1%, 75.0%, and 79.1% of low-frequency ultrasonography had certain advantages 14 . A study of 120 patients with EA found that the diagnostic accuracy rate of color Doppler ultrasonography for EA was 90.00%, the misdiagnosis rate was 3.57%, and the missed diagnosis rate was 6.25% 15 .…”