Esophageal Atresia: Gastroesophageal functional follow-up in 5–15year old children

Pedersen, Rikke Neess; Markøw, Simone; Kruse-Andersen, S; Qvist, Niels; Hansen, Tine Plato; Gerke, Oke; Nielsen, Rasmus Gaardskær; Rasmussen, Lars Melholt; Husby, Steffen

doi:10.1016/j.jpedsurg.2013.07.019

Cited by 84 publications

(102 citation statements)

References 68 publications

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“…According to van Wijk et al [23], transient lower esophageal sphincter relaxation was the most common mechanism underlying gastroesophageal reflux disease in infants, delayed bolus clearance and delayed gastric emptying. Besides esophagitis, Barrett esophagus and adenocarcinoma may also develop [17,24,25]. In our study, in one child, gastric metaplasia was present in the lower part of the esophagus.…”

Section: Discussionmentioning

confidence: 52%

Assessment of Clinical Symptoms and Multichannel Intraluminal Impedance and pH Monitoring in Children After Thoracoscopic Repair of Esophageal Atresia and Distal Tracheoesophageal Fistula

Iwańczak¹,

Kosmowska-Miśków²,

Kofla-Dłubacz³

et al. 2016

Adv Clin Exp Med

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Section: Discussionmentioning

confidence: 52%

Assessment of Clinical Symptoms and Multichannel Intraluminal Impedance and pH Monitoring in Children After Thoracoscopic Repair of Esophageal Atresia and Distal Tracheoesophageal Fistula

Iwańczak¹,

Kosmowska-Miśków²,

Kofla-Dłubacz³

et al. 2016

Adv Clin Exp Med

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“…It is secondary to esophageal dysmotility, short esophagus, lower esophageal sphincter pressure, and chronic lung disease. 4,17,18 Dysmotility is the result of intrinsic factors related to abnormal esophagus development or partial denervation during surgery. Motor patterns were described in a cohort of children with EA using a high resolution manometry.…”

Section: Esophageal Atresiamentioning

confidence: 99%

“…The treatment of choice is surgical repair with potential late complications such as dysphagia, gastroesophageal reflux, strictures, and dysmotility. [3][4][5] An increased risk of EoE has been described in patients with successful repair of EA secondary to gastroesophageal reflux disease (GERD), esophageal dysmotility, and the genetic similarities common to both conditions: the mutations in the Forkhead box (FOX) gene cause congenital anomalies, such as EA. In addition, FOXF1 genes are present in the promoter region of inflammation, including eotaxin-3, which is increased in EoE; therefore, Gorter et al proposed that patients with EA may have a greater risk for developing EoE.…”

Section: Introductionmentioning

confidence: 99%

Eosinophilic esophagitis and esophageal atresia: coincidence or causality?

Salgado

Rocca

2018

Arch Argent Pediatr

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Eosinophilic esophagitis is an immune-mediated chronic disease of the esophagus characterized by symptoms related to esophageal dysfunction and tissue eosinophilia. In the endoscopy, the esophageal mucosa may appear normal or show exudates, rings, edema, furrows, and strictures. Its management is based on elimination diet, topical corticosteroids and/or esophageal dilation. Atresia is the most common congenital alteration of the esophagus; it requires surgical repair and poses potential complications, such as gastroesophageal reflux, strictures, and esophageal dysmotility. Up to 2015, 48 cases of eosinophilic esophagitis and esophageal atresia were reported, with dysmotility, reflux, and long-term acid suppression involvement. Prevalent clinical signs include dysphagia, difficulty eating, and reflux symptoms, so an esophagogastroduodenoscopy with biopsy is recommended to rule out associated eosinophilic esophagitis in patients with esophageal atresia and persistent symptoms before performing an esophageal dilation and/or anti-reflux surgery. If eosinophilic esophagitis is confirmed, it should be managed with the corresponding drugs, and the subsequent therapeutic approach will depend on its clinical course.

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“…Es secundaria a dismotilidad esofágica, un esófago corto, disminución de la presión del esfínter esofágico inferior y enfermedad pulmonar crónica. 4,17,18 La dismotilidad se debe a factores intrínsecos relacionados con el desarrollo anormal del esófago o con la denervación parcial durante la cirugía. Los patrones motores fueron descritos en una cohorte de niños con AE usando manometría de alta resolución.…”

Section: Atresia De Esófagounclassified

“…El tratamiento de elección es la corrección quirúrgica, con posibles complicaciones alejadas, como disfagia, reflujo gastroesofágico, estenosis y dismotilidad. [3][4][5] Se ha descrito un riesgo aumentado de EEo en pacientes con AE corregida secundario a enfermedad por reflujo gastroesofágico (ERGE), dismotilidad esofágica y a las similitudes genéticas que comparten ambas patologías: mutaciones en el gen Forkhead box (FOX) producen anomalías congénitas, como AE. Además, los genes FOXF1 están presentes en la región promotora de inflamación, que incluyen eotaxina-3, la cual está proponen que los pacientes con AE podrían tener mayor posibilidad de desarrollar EEo.…”

Section: Introductionunclassified

Esofagitis eosinofílica y atresia esofágica: ¿casualidad o causalidad?

Salgado¹,

Rocca²

2018

Arch Argent Pediatr

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RESUMENLa esofagitis eosinofílica es una enfermedad crónica del esófago, inmunomediada, caracterizada por síntomas de disfunción esofágica y eosinofilia tisular. Endoscópicamente, la mucosa esofágica puede ser normal o tener exudados, anillos, edema, surcos y estenosis. El tratamiento se basa en dieta de exclusión, corticoterapia tópica y/o dilatación esofágica. La atresia es la alteración congénita más frecuente del esófago, requiere corrección quirúrgica con posibles complicaciones, como reflujo gastroesofágico, estenosis y dismotilidad esofágica. Hasta el año 2015, fueron comunicados 48 casos de esofagitis eosinofílica en atresia esofágica, en los que tuvo participación la dismotilidad, el reflujo y la supresión ácida prolongada. Clínicamente, predominan la disfagia, las dificultades en la alimentación y los síntomas de reflujo, por tanto, se sugiere la endoscopía digestiva alta con biopsias para descartar esofagitis eosinofílica asociada en pacientes con atresia esofágica y síntomas persistentes antes de realizar dilatación esofágica y/o cirugía antirreflujo. Si se confirma esofagitis eosinofílica, debe tratarse con medicación apropiada y subsiguientes conductas terapéuticas dependerán de su evolución. Palabras clave: esofagitis eosinofílica, atresia esofágica, disfagia.

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Esophageal Atresia: Gastroesophageal functional follow-up in 5–15year old children

Cited by 84 publications

References 68 publications

Assessment of Clinical Symptoms and Multichannel Intraluminal Impedance and pH Monitoring in Children After Thoracoscopic Repair of Esophageal Atresia and Distal Tracheoesophageal Fistula

Assessment of Clinical Symptoms and Multichannel Intraluminal Impedance and pH Monitoring in Children After Thoracoscopic Repair of Esophageal Atresia and Distal Tracheoesophageal Fistula

Eosinophilic esophagitis and esophageal atresia: coincidence or causality?

Esofagitis eosinofílica y atresia esofágica: ¿casualidad o causalidad?

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