Esophageal cancer in Iran; a population-based study regarding adequacy of cancer surgery and overall survival

Harirchi, Iraj; Kolahdoozan, Shadi; Hajizadeh, Sohrab; Safari, Fatemeh; Sedighi, Zahra; Nahvijou, Azin; Mir, Mohammad-Reza; Mousavi, Seyed Mohsen; Zendehdel, Kazem

doi:10.1016/j.ejso.2013.10.011

Cited by 17 publications

(22 citation statements)

References 17 publications

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“…Samadi et al (2007) reported a median survival of 9 months for EC patients from North-West of Iran. Similarly, a median survival time of 8.5 months was reported in a nation-wide study from Iran (Harirchi et al, 2014). Mir et al (2013) reported a median survival of 11.5 months and a 5-year survival rate of 10% for EC patients from Tehran, Iran.…”

Section: Discussionsupporting

confidence: 54%

Predictors of survival in oesophageal cancer patients in a high-risk area in Northern Iran: the role of health services utilisation

et al. 2016

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We aimed to determine predictors of survival in oesophageal cancer (EC) patients in a high-risk area. This study was conducted on EC patients diagnosed in 2007-2008 in Golestan province, Iran. Diagnostic (DU) and Therapeutic (TU) services utilisation indices were determined. DU and TU indices of 1 were considered as good utilisation. EC-specific survival rates were calculated. Multivariate Cox-regression model was used to calculate adjusted hazard ratios (AHRs). Two hundred and twenty-three EC subjects were enrolled. The median survival time was 10.47 months and the 5-year survival rate was 11%. Cox-regression analysis suggested that stage of tumour (AHR = 3.75, 95% confidence interval [CI]: 2.34-6.00; AHR = 12.21, 95% CI: 7.42-20.08) and TU (AHR = 1.78, 95% CI: 1.25-2.52) were the strongest variables related to EC survival. The median survival time in patients with good and poor TU were 14.37 and 8.53 months respectively (p < .01). There was no significant relationship between DU and EC survival. We found relatively low survival rates in our EC patients when compared with developed countries. Our results also suggested an increasing trend for EC survival rate during recent years. Good TU could predict higher survival rates. Patients' access to therapeutic services may be considered as an important indicator in decision-making for controlling EC.

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Section: Discussionsupporting

confidence: 54%

Predictors of survival in oesophageal cancer patients in a high-risk area in Northern Iran: the role of health services utilisation

et al. 2016

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“…In contrast to the situation in other parts of the world, esophageal cancer was found to be more common in women than men, as shown both in this and other studies conducted in the same region (the Lake Van region, in eastern Turkey) (1,2,18). The average age in this study was lower (56 years old) than the mean age reported in other studies from Eastern and Western countries (3,19). Most of our patients' performance scores were good (the ASA scores of 78.4% of all patients were ASA-1 or ASA-2).…”

Section: Discussioncontrasting

confidence: 49%

“…The situation is nearly the same for Middle Eastern countries (3). Although multimodal therapies are accepted as standard treatment, there are still controversies surrounding both surgical and chemoradiotherapy strategies (4).…”

Section: Introductionmentioning

confidence: 97%

Changing trends and experience with esophageal cancer surgery in a single university hospital: are the results similar or not?

Çelik¹,

Doğan²,

Arslan³

et al. 2017

Bagcilar Medical Bulletin

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Objective:The main treatment modality for esophageal cancer remains to be surgery. Over the last decades, surgical strategies have evolved remarkably. When neoadjuvant chemoradiotherapy became standard, discussions about the role, type, and timing of surgery began. In this study, we share results we obtained after operating our patients using various surgical techniques. Material and Methods: Reliable data from 51 esophageal cancer patients were evaluated retrospectively. Of the 51 cases, 31 were operable. These operable cases were further classified according to surgical method and neoadjuvant therapy status. Median survival time in months, complications, hospital mortality, length of hospital stay, and pathology results (total lymph nodes harvested and pathologic tumor node metastasis stage [p_TNM]) were documented for the different surgical approaches. Results: Open surgical methods were performed in 21 cases, while in 10 cases the Minimally Invasive Surgery (MIS) method was used. The MIS group received neoadjuvant therapy more frequently than the open surgical methods group (p=0.013). Although more complications were observed in the MIS group, the difference to the open esophagectomy methods group was not significant. Patients in the MIS group also had longer hospital stays, but again the difference was not significant. Although a pathologic complete response was seen in 8 of the 11 (72.7%) patients in our study who received chemoradiotherapy as neoadjuvant treatment, the surgical results of patients who received chemoradiotherapy were worse, although not to a statistically significant extent. Conclusion: Despite changing trends and treatment options in esophageal cancer surgery, we have yet to see the expected improved results. Keywords: esophagus cancer, minimally invasive surgery, neoadjuvant therapy ÖZETÖzofagus kanser cerrahisinde tek üniversite hastanesi deneyimleri ve değişen trendler; sonuçlar değişti mi?Amaç: Özofagus kanserinin temel tedavi yöntemi cerrahi olarak devam etmektedir. Son dekatlarda cerrahi yöntemlerde ciddi ilerlemeler olmuştur. Neoadjuvan kemoradioterapinin stantdart hale gelmesi ile beraber, cerrahinin tedavideki yeri, cerrahi yöntemin tipi ve zamanlaması tartışılmaya başlanmıştır. Bu çalış-mada, farklı cerrahi yöntemler ile tedavi edilen vakalarımızın sonuçları paylaşıldı. Yöntem: Özofagus kanserli 51 vakanın verileri retrospektif olarak değerlendirildi. Bu 51 vakanın 31 tanesi operable idi. Ameliyat edilen 31 vaka, ayrıca cerrahi yönteme ve neoadjuvant kemoradioterapiye göre alt gruplara ayrıldı. Ay olarak median sağ-kalım süreleri, komplikasyonlar, hastane mortaliteleri, yatış süreleri ve patoloji sonuçları (toplam çıkarılan lenf nodu sayısı, TNM sınıflaması) farklı cerrahi tekniklere göre yorumlandı. Bulgular: Açık cerrahi teknikler ile 21 vaka ameliyat edilirken, 10 vaka minimal invazif yöntemler (MİY) ile ameliyat edildi. Açık cerrahi yöntemlere göre MİY ile ameliyat olanlar daha sıklıkla neoadjuvant tedavi almış idi (p=0.013). MİY ile ameliyat olan grupta daha fazla ...

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“…Studies have shown that the 5-year survival rate is less than 20% in men. For instance, Harirchi et al showed that it was less than 15% in Iran (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Burden of Esophageal Cancer According to World Health Organization Regions: Review of Findings from the Global Burden of Disease Study 2015

et al. 2019

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Background: Esophageal carcinoma is regarded as a malignant disease with fatal consequences. In cancers, it was the sixth cause of death in the world, with an estimated 439025 deaths in 2015. Objectives: We conducted a research to evaluate the esophageal carcinoma burden based on the World Health Organization regions, during 2000 to 2015.Methods: Global Burden of Disease (GBD) was used to retrospectively collect the data from 2000 to 2015. The Institute for Health Metrics and Evaluation publishes the data. We utilized disability adjusted life years (DALY), incidence rate and prevalence rate to describe the esophageal cancer burden in the world. Results: In 2015, there were a total of 9854406 DALYs attributed to esophageal cancer where the majority were related the years of life lost (YLL) (9725791), and 128613 of the total were concerned with years lost due to disability (YLD). The highest of DALYs was in the Western Pacific region with 4773660 of the total. The Eastern Mediterranean region, with 516412 DALYs, shows the lowest number. Conclusions: The esophageal carcinoma is still a public health problem in high incidence countries. In all countries, the majority of the DALYs is related to YLL, indicating that prevention and early detection should be taken seriously. The burden of esophageal cancer is different in geographical regions. Therefore, a suitable and specific program in every region and country should be developed.

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Esophageal cancer in Iran; a population-based study regarding adequacy of cancer surgery and overall survival

Cited by 17 publications

References 17 publications

Predictors of survival in oesophageal cancer patients in a high-risk area in Northern Iran: the role of health services utilisation

Predictors of survival in oesophageal cancer patients in a high-risk area in Northern Iran: the role of health services utilisation

Changing trends and experience with esophageal cancer surgery in a single university hospital: are the results similar or not?

Burden of Esophageal Cancer According to World Health Organization Regions: Review of Findings from the Global Burden of Disease Study 2015

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