Esophageal cancer

Thompson, William M.

doi:10.1016/0360-3016(83)90329-2

Cited by 27 publications

(3 citation statements)

References 109 publications

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“…Before 1987, the AJCC staging system used tumor length (T1, <5 cm; T2, >5 cm; and T3, evidence of extraesophageal spread) to predict patient prognosis (14). However, at the 1987 AJCC annual meeting, the current TNM staging system was adopted, in which tumor length is not a staging criterion (15,16).…”

Section: Discussionmentioning

confidence: 99%

Tumor length in elderly patients with esophageal squamous cell carcinoma: Is it a prognostic factor?

Feng¹,

Huang²,

Zhou³

2013

Upsala Journal of Medical Sciences

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BackgroundSeveral researchers have determined the tumor length to be an important prognostic indictor of esophageal cancer (EC). However, controversy exists concerning the optimal cut-off points for tumor length to predict overall survival. The aim of this study was to determine the prognostic value of tumor length and propose the optimum cut-off point for tumor length in predicting survival difference in elderly patients with esophageal squamous cell carcinoma (ESCC).MethodsFrom January 2001 to December 2009, a retrospective analysis of 132 consecutive patients older than 70 years with ESCC was conducted. A receiver-operating characteristic (ROC) curve for survival prediction was plotted to verify the optimum cut-off point for tumor length. Univariate and multivariate analyses were performed to evaluate prognostic parameters for survival.ResultsA ROC curve for survival prediction was plotted to verify the optimum cut-off point for tumor length, which was 4.0 cm. Patients with tumor length ≤4.0 cm had significantly better 5-year survival rate than patients with a tumor length >4.0 cm (60.7% versus 31.6%, P = 0.007). Multivariate analyses showed that tumor length (>4.0 cm versus ≤4.0 cm, P = 0.036), differentiation (poor versus well/moderate, P = 0.032), N staging (N1-3 versus N0, P = 0.018), and T grade (T3-4 versus T1-2, P = 0.002) were independent prognostic factors.ConclusionTumor length is a predictive factor for long-term survival in elderly patients with ESCC, especially in T3-4 grade or nodal-negative patients. We conclude that 4.0 cm may be the optimum cut-off point for tumor length in predicting survival in elderly patients with ESCC.

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Section: Discussionmentioning

confidence: 99%

Tumor length in elderly patients with esophageal squamous cell carcinoma: Is it a prognostic factor?

Feng¹,

Huang²,

Zhou³

2013

Upsala Journal of Medical Sciences

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“…Historically tumor length has been used as a part of the staging criteria. In the 1983 version of TNM (AJC) staging system for esophageal tumors, a clinical criteria was used, which included tumor length [22]. Tumors less than 5 cm in length which were causing no obstruction and were not circumferential were considered T1, whereas tumors greater than 5 cm in length or that were causing obstruction or were circumferential were designated T2.…”

Section: Multivariate Survival Analysismentioning

confidence: 99%

Tumor length as a prognostic factor in esophageal malignancy: Univariate and multivariate survival analyses

Griffiths

Brummell

Gorthi

et al. 2006

Journal of Surgical Oncology

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“…Currently there is no universally accepted method to accurately define the cranial and caudal limits of the primary oesophageal tumour when delineating the gross tumour volume (GTV) for radiotherapy planning. Oesophagography was once routinely used to determine the cranial and caudal extent of the tumour; however it does not define the radial extent of disease [1] . With computed tomography (CT) planning, it is possible to better define the radial extent of the primary tumour but it is less accurate in defining the cranial and caudal extent of the tumour than oesophagography [2] .…”

Section: Introductionmentioning

confidence: 99%

Follow up results of a prospective study to evaluate the impact of FDG-PET on CT-based radiotherapy treatment planning for oesophageal cancer

Tan

Osbourne

et al. 2017

Clinical and Translational Radiation Oncology

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BackgroundThis prospective study aims to determine the impact of PET/CT on radiotherapy planning and outcomes in patients with oesophageal cancer.MethodsAll patients underwent PET/CT scanning in the radiotherapy treatment position, and received treatment planned using the PET/CT dataset. GTV was defined separately on PET/CT (GTV-PET) and CT (GTV-CT) datasets. A corresponding PTV was generated for each patient. Volumetric and spatial analysis quantified the proportion of FDG-avid disease not included in CT-based volumes. Clinical data was collected to determine locoregional control and overall survival rates.Results13 (24.1%) of 57 accrued patients had metastatic disease detected on PET. Median follow up was 4 years. FDG-avid disease would have been excluded from GTV-CT in 29 of 38 patients (76%). In 5 patients, FDG-avid disease would have been completely excluded from the PTV-CT. GTV-CT underestimated the cranial and caudal extent of FDG-avid tumour in 14 (36%) and 10 (26%) patients. 4-Year overall survival and locoregional failure free survival were 37% and 65%.ConclusionsPET/CT altered the delineation of tumour volumes when compared to CT alone, and should be considered standard for treatment planning. Although clinical outcomes were not improved with PET/CT planning, it did allow the use of smaller radiotherapy volumes.

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Esophageal cancer

Cited by 27 publications

References 109 publications

Tumor length in elderly patients with esophageal squamous cell carcinoma: Is it a prognostic factor?

Tumor length in elderly patients with esophageal squamous cell carcinoma: Is it a prognostic factor?

Tumor length as a prognostic factor in esophageal malignancy: Univariate and multivariate survival analyses

Follow up results of a prospective study to evaluate the impact of FDG-PET on CT-based radiotherapy treatment planning for oesophageal cancer

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