Esophageal dysmotility and gastroesophageal reflux disease

Diener, Urs; Patti, Marco G.; Molena, Daniela; Fisichella, P. Marco; Way, Lawrence W.

doi:10.1016/s1091-255x(01)80046-9

Cited by 185 publications

(139 citation statements)

References 20 publications

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“…In addition, although gastro-oesophageal reflux disease (GORD) has been associated with IOM [5][6][7] , it is not known whether particular manometric subsets of IOM display a higher prevalence of GORD.…”

Section: Introductionmentioning

confidence: 99%

Ineffective oesophageal motility: Manometric subsets exhibit different symptom profiles

Haack¹,

Hansen²,

Malcolm³

et al. 2008

WJG

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AIM:To compare the demographic and clinical features of different manometric subsets of ineffective oesophageal motility (IOM; defined as ≥ 30% wet swallows with distal contractile amplitude < 30 mmHg), and to determine whether the prevalence of gastro-oesophageal reflux differs between IOM subsets. METHODS: Clinical characteristics of manometric subsets were determined in 100 IOM patients (73 female, median age 58 years) and compared to those of 100 age-and gender-matched patient controls with oesophageal symptoms, but normal manometry. Supine oesophageal manometry was performed with an eight-channel DentSleeve water-perfused catheter, and an ambulatory pH study assessed gastrooesophageal reflux. RESULTS: Patients in the IOM subset featuring a majority of low-amplitude simultaneous contractions (LASC) experienced less heartburn (prevalence 26%), but more dysphagia (57%) than those in the IOM subset featuring low-amplitude propagated contractions (LAP; heartburn 70%, dysphagia 24%; both P ≤ 0.01). LASC patients also experienced less heartburn and more dysphagia than patient controls (heartburn 68%, dysphagia 11%; both P < 0.001).The prevalence of heartburn and dysphagia in IOM patients featuring a majority of non-transmitted sequences (NT) was 54% (P = 0.04 vs LASC) and 36% (P < 0.01 vs controls), respectively. No differences in age and gender distribution, chest pain prevalence, acid exposure time (AET ) and symptom/reflux association existed between IOM subsets, or between subsets and controls. CONCLUSION: IOM patients with LASC exhibit a different symptom profile to those with LAP, but do not differ in gastro-oesophageal reflux prevalence. These findings raise the possibility of different pathophysiological mechanisms in IOM subsets, which warrants further investigation.

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Section: Introductionmentioning

confidence: 99%

Ineffective oesophageal motility: Manometric subsets exhibit different symptom profiles

Haack¹,

Hansen²,

Malcolm³

et al. 2008

WJG

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“…In another study performed by Vinjirayer et al (13), the authors do not illustrate that IEM was the major determinant of abnormal esophageal acid exposure, but they interpreted that their data did not disprove some association between GERD and IEM. Although it was not proven in all studies, in two large series of patients with confirmed GERD, mucosal injury was described to be more severe (6,14).…”

Section: Discussionmentioning

confidence: 96%

Ineffective esophageal motility and gastroesophageal reflux disease: A close relationship?

Ergün

Doğan²,

Ünal³

2012

Turk J Gastroenterol

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“…Most of the previous studies restricted the enrolled subjects to the GERD patients. IEM was associated with reflux esophagitis in some studies of patients with confirmed GERD [6,24] . However, other studies showed that the presence of reflux esophagitis was similar between the patients with IEM and those patients with normal esophageal peristalsis [20] and there was no difference in the severity of IEM when comparing the erosive and non-erosive GERD patients [23] .…”

Section: Discussionmentioning

confidence: 96%

“…Increased acid exposure in these patients is associated with the development of erosive esophagitis and GERD-Kim KY et al . Is IEM associated with GPRD 6031 associated respiratory symptoms [5,6] . Gastropharyngeal reflux, also called laryngopharyngeal reflux, is a term used to describe esophageal acid reflux into the laryngeal and pharyngeal areas.…”

Section: Introductionmentioning

confidence: 99%

Is ineffective esophageal motility associated with gastropharyngeal reflux disease?

Kim

Kim²,

Kim³

et al. 2008

WJG

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AIM:To evaluate the association between ineffective esophageal motility (IEM) and gastropharyngeal reflux disease (GPRD) in patients who underwent ambulatory 24-h dual-probe pH monitoring for the evaluation of supraesophageal symptoms. METHODS: A total of 632 patients who underwent endoscopy, esophageal manometry and ambulatory 24-h dual-pH monitoring due to supraesophageal symptoms (e.g. globus, hoarseness, or cough) were enrolled. Of them, we selected the patients who had normal esophageal motility and IEM. The endoscopy and ambulatory pH monitoring findings were compared between the two groups. RESULTS: A total of 264 patients with normal esophageal motility and 195 patients with the diagnosis of IEM were included in this study. There was no difference in the frequency of reflux esophagitis and hiatal hernia between the two groups. All the variables showing gastroesophageal reflux and gastropharyngeal reflux were not different between the two groups.

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Esophageal dysmotility and gastroesophageal reflux disease

Cited by 185 publications

References 20 publications

Ineffective oesophageal motility: Manometric subsets exhibit different symptom profiles

Ineffective oesophageal motility: Manometric subsets exhibit different symptom profiles

Ineffective esophageal motility and gastroesophageal reflux disease: A close relationship?

Is ineffective esophageal motility associated with gastropharyngeal reflux disease?

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