Esophageal Function and Gastroesophageal Reflux during Sleep and Waking in Patients with Chronic Obstructive Pulmonary Disease

Orr, William C.; Shamma-Othman, Zeina; Allen, Melvin L.; Robinson, Malcolm

doi:10.1378/chest.101.6.1521

Cited by 28 publications

(33 citation statements)

References 18 publications

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“…In agreement with the presented data, pulmonary function tests in the study by DUCULONÉ et al [13] did not show any differences between patients with and without reflux. In the only report where patients were studied with 24 h pH monitoring, ORR et al [14] did not find GERD in 12 patients with COPD, even though the majority of the patients had a positive history of reflux-related symptoms. However, the population in the study by ORR et al [14] was not comparable with the present study because nine of the 12 COPD patients had a positive bronchodilator response in the spirometry test and may have had asthma.…”

Section: Discussionmentioning

confidence: 93%

“…In the only report where patients were studied with 24 h pH monitoring, ORR et al [14] did not find GERD in 12 patients with COPD, even though the majority of the patients had a positive history of reflux-related symptoms. However, the population in the study by ORR et al [14] was not comparable with the present study because nine of the 12 COPD patients had a positive bronchodilator response in the spirometry test and may have had asthma. Recently, MOKHLESSI et al [15], using a modified version of a validated GERD questionnaire given to w100 patients, observed a high prevalence of mild GERD symptoms in patients with COPD.…”

Section: Discussionmentioning

confidence: 93%

“…Although it is believed that COPD is associated with peptic ulcer disease, this association has not been systematically evaluated. Furthermore, the true prevalence of GERD in COPD patients has to date been evaluated in only four studies [12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…To the knowledge of the present authors, only four prospective studies have investigated the relationship between GERD and COPD [12][13][14][15]. Three of these studies showed an increased prevalence.…”

mentioning

confidence: 99%

“…In the other [15], GERD was evaluated only by survey. Moreover, only one study used 24 h pH monitoring in 12 COPD patients without a control population [14]. The authors of the latter study found no increased prevalence of GERD [14].…”

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confidence: 99%

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Increased gastro-oesophageal reflux disease in patients with severe COPD

Casanova¹,

Baudet²,

Velasco³

et al. 2004

Eur Respir J

151

126

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The prevalence and clinical consequences of gastro-oesophageal reflux disease (GERD) in chronic obstructive pulmonary disease (COPD) are not well characterised.The present study prospectively studied 42 males with COPD (forced expiratory volume in one second % predicted: 35%, range 20-49) and 16 healthy volunteers of similar age without respiratory or gastro-oesophageal symptoms. The diagnosis of GERD was confirmed using oesophageal 24 h pH monitoring. In the current study group, reflux symptoms were measured using the Vigneri score, cough and dyspnoea with the modified Medical Research Council questionnaire, and pulmonary function with bronchodilator response and health status using St George9s Respiratory Questionnaire.Pathological reflux was documented in 26 out of 42 patients (62%) and in three volunteers (19%). In patients with GERD, 15 patients (58%) did not report any reflux symptoms. There were no differences in symptoms, health status, bronchodilator treatment and pulmonary function test between patients with and without GERD. Oxygen desaturation coincided with episodes of increased oesophageal acidity in 40% of patients with GERD.Patients with severe chronic obstructive pulmonary disease have a high prevalence of asymptomatic gastro-oesophageal reflux. The association between this reflux and oxygen desaturation deserves further attention. Eur Respir J 2004; 23: 841-845.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Increased gastro-oesophageal reflux disease in patients with severe COPD

Casanova¹,

Baudet²,

Velasco³

et al. 2004

Eur Respir J

151

126

View full text Add to dashboard Cite

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Gastro‐Oesophageal Reflux

DiBaise¹

2007

Chronic Obstructive Pulmonary Disease

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Aims-To study the epidemiology and natural history of gastro-oesophageal reflux disease (GORD). Methods-Retrospective cohort study involving all 172 hospitals of the Department of Veterans AVairs. A total of 194 527 patients with GORD were followed between 1981 and 1994. Distribution of oesophagitis, oesophageal ulcer, oesophageal stricture, strictured hiatus hernia, hiatus hernia, and pyrosis by age, sex, and ethnicity were determined. The comorbid occurrence of various forms of GORD in identical patients was analysed by an age and race standardised morbidity ratio. The population of all hospitalised veterans was used for comparison. Results-Severe forms of GORD associated with oesophageal erosions, ulcers, or strictures, aVected elderly, white, male patients more often than their corresponding opposite demographic group. All forms of GORD clustered in the same patient population; on average, any form of GORD was 10 times more likely to occur in a patient with another form of GORD than without. The highest morbidity ratio (22) was found in oesophageal ulcer and stricture. About one third of all patients with oesophageal erosions, ulcers, or strictures also had hiatus hernia; 46% of patients with hiatus hernia were diagnosed as having other forms of GORD. While one third of all oesophageal strictures appeared in patients without other forms of GORD diagnosed at any time, oesophageal ulcers were always associated with some other form of GORD. No clear cut progression in diVerent forms of GORD was found. Conclusions-Older age, male sex, and white ethnicity are risk factors in the development of severe forms of GORD. The most severe grade of GORD is reached at the onset of the disease.

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GER in Asthma and COPD

Akkanti

Hanania

2012

Gastroesophageal Reflux and the Lung

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Esophageal Function and Gastroesophageal Reflux during Sleep and Waking in Patients with Chronic Obstructive Pulmonary Disease

Cited by 28 publications

References 18 publications

Increased gastro-oesophageal reflux disease in patients with severe COPD

Increased gastro-oesophageal reflux disease in patients with severe COPD

Gastro‐Oesophageal Reflux

GER in Asthma and COPD

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