Esophageal, Gastric, and Duodenal Histologic Findings in Patients with Feeding Difficulties

Edwards, J. A. C.; Friesen, Craig A.; Issa, Amy; Edwards, Sarah

doi:10.3390/nu12092822

Cited by 3 publications

(1 citation statement)

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“…A recent study in pediatric patients with rumination syndrome demonstrated increased eosinophil and mast cell densities in the gastric antrum [12]. Reports indicate a high proportion of patients with feeding difficulties who have undergone esophagogastroduodenoscopy (EGD), demonstrate some degree of inflammation on biopsies [4,13], with a subset including those with eosinophilia [14]. It is unknown whether mast cell density and eosinophilia contribute to symptoms of decreased volume or variety of foods ingested in these children.…”

Section: Introductionmentioning

confidence: 99%

Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake

et al. 2022

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Background: Reports indicate patients with feeding difficulties demonstrate signs of inflammation on biopsies, notably eosinophilia, but it is unknown whether mast cell density contributes to variety or volume limitation symptoms. The aim of our study was to evaluate eosinophil and mast cell density of EGD biopsies in pediatric patients with symptoms of decreased volume or variety of ingested foods. Methods: We conducted a single-center, retrospective chart review of EMRs for all new feeding clinic patients between 0 and 17 years of age. Patients were categorized by symptoms at the initial visit as well as eosinophil and mast cell densities in those with EGD biopsies. Ten patients were identified as controls. Results: We identified 30 patients each with volume and variety limitation. Antral mast cell density was increased in 32.1% of variety-limited patients, 37.5% of volume limited patients, and in no controls; Duodenal mast cell density was increased in 32.1% of variety-limited patients, 40.6% of volume-limited patients, and in no controls. Conclusions: In both variety- and volume-limited patients, antral and duodenal mast cell densities were increased. These associations warrant further investigation of the mechanism between mast cells and development of feeding difficulties, allowing more targeted pediatric therapies.

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Section: Introductionmentioning

confidence: 99%

Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake

et al. 2022

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Feeding Characteristics in Children With Food Allergies: A Scoping Review

Kefford,

Marshall,

Packer

et al. 2024

J Speech Lang Hear Res

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Background: Food allergy (FA) affects approximately 8% of children and may be immunoglobulin E (IgE)-mediated or non-IgE-mediated. It is recognized clinically that children with both subtypes of FA may present with features of pediatric feeding disorder (PFD); however, there is currently a limited detail of presenting characteristics. Objective: The objective of this study was to synthesize the current evidence regarding the feeding characteristics of children with FA, with a focus on the feeding skills and psychosocial domains of PFD. Method: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines. Papers published between 2001 and 2022 describing feeding characteristics in the feeding skills and psychosocial domains in children with FA/history of FA were included. Papers that focused solely on characteristics from the medical or nutritional domains were excluded. Descriptive information regarding demographics, methodology, allergy profile and history, and the characteristics of PFD observed was extracted using a preconceived data extraction form. Results: Overall, 40 papers contained descriptions of feeding characteristics of children with non-IgE-mediated FA ( n = 22) and IgE-mediated FA ( n = 11), while four were nonspecific. In the psychosocial domain, food refusal/aversion, anxiety with eating, and poor intake were the most frequently reported, regardless of FA subtype. Less information was reported regarding feeding skills, although slowness in eating, immature diet, and delays in oral sensory-motor skills were described. Conclusions: Children with FA/history of FA may present with a range of characteristics that map across the feeding skill and psychosocial domains of PFD. Systematic research is needed to fully describe the feeding characteristics of children with FA. Supplemental Material: https://doi.org/10.23641/asha.24562732

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Multifocal neuromuscular hamartoma with smooth muscle and Schwannian components

Atchison,

Ilyas,

Satturwar

et al. 2024

BMJ Case Rep

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A male in his early 20s with gastro-oesophageal reflux disease and severe weight loss was found to have two intrabdominal masses causing his symptoms: one in the gastro-oesophageal junction and the other occupying the coeliac plexus in the cardiophrenic region. These masses were surgically removed and sent to pathology where they were found to be smooth muscle hamartomas with Schwannian components. These represent a unique presentation of benign smooth muscle tumours that is not typically seen in young adults, especially in the cardiophrenic region involving the coeliac plexus.

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Esophageal, Gastric, and Duodenal Histologic Findings in Patients with Feeding Difficulties

Cited by 3 publications

References 10 publications

Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake

Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake

Feeding Characteristics in Children With Food Allergies: A Scoping Review

Multifocal neuromuscular hamartoma with smooth muscle and Schwannian components

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