Esophageal Involvement in Scleroderma: Clinical, Endoscopic, and Manometric Features

Lahcene, M.; Oumnia, N.; Matougui, N.; Boudjella, M.; Tebaibia, A.; Touchene, B.

doi:10.5402/2011/325826

Cited by 38 publications

(36 citation statements)

References 25 publications

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“…This feature is especially prevalent in scleroderma-spectrum CTD. 37 While GER is non-specific and commonly encountered in patients with IPF 38 , some have suggested that esophageal dysmotility may be more specific for CTD and should be reconsidered in subsequent IPAF criteria iterations. 39,40 Similarly, because proximal muscle weakness and myalgia are among the most common clinical manifestations in patients with polymyositis and dermatomyositis as a whole 41 , some have advocated for inclusion of these features in the IPAF clinical domain.…”

Section: Unanswered Questionsmentioning

confidence: 99%

Interstitial Pneumonia With Autoimmune Features: Overview of Proposed Criteria and Recent Cohort Characterization

Lee

Oldham

2017

Clinical Pulmonary Medicine

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The accurate diagnosis of interstitial lung disease (ILD) is essential for optimal prognostication and management. While connective tissue disease (CTD) is among the most common causes of ILD, some patients have features suggestive of autoimmunity without meeting criteria for a specific CTD. To help define and study this disease entity more uniformly, a 2015 research statement proposed consensus-based criteria and coined the term “interstitial pneumonia with autoimmune features” (IPAF). In this review, we summarize and compare previously proposed criteria to characterize these patients, provide an overview of the IPAF criteria and highlight recent investigations aimed at characterizing IPAF cohorts. We then call attention to questions that have arisen with the application of the IPAF criteria and discuss future areas of study.

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Section: Unanswered Questionsmentioning

confidence: 99%

Interstitial Pneumonia With Autoimmune Features: Overview of Proposed Criteria and Recent Cohort Characterization

Lee

Oldham

2017

Clinical Pulmonary Medicine

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“…As a result, GERD develops in patients with scleroderma. In many cross-sectional studies using different methodologies, the prevalence of GERD has been reported to be at rates of up to 70% (9)(10)(11)(12)(13)(14)(15). (18), GERD prevalence was found to be 40.7%.…”

Section: Systemic Sclerosismentioning

confidence: 99%

Which diseases are risk factors for developing gastroesophageal reflux disease?

Akyüz

Soyer²

2017

Turk J Gastroenterol

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Gastroesophageal reflux disease (GERD) is known to present with various extraesophageal symptoms and complications. In contrast, several diseases affecting the motility of the esophagus and some approaches that alter the upper gastrointestinal tract anatomy may result in GERD. Certain diseases and conditions often mentioned with GERD will be briefly discussed in this section. Systemic SclerosisEsophageal motility is impaired in 70-90% of patients with systemic sclerosis (1-3). On histological examination, smooth muscle atrophy and fibrosis causing motor activity abnormalities in two-thirds of the distal esophagus are often determined (4). Motility studies have shown that the amplitude of peristaltic contractions decreases or that there is no peristaltic contraction in this region (5-7). Abnormal peristalsis and decreased lower esophageal sphincter (LES) pressure reduce acid clearance and prolong the contact of acid with the mucosa (8). As a result, GERD develops in patients with scleroderma. In many cross-sectional studies using different methodologies, the prevalence of GERD has been reported to be at rates of up to 70% (9-15). Diabetes MellitusFurthermore, various factors showing tendency to GERD were identified in diabetes mellitus. Among these,• Reduced salivary secretion associated with diabetic neuropathy, • Delayed gastric emptying, • Decreased acid clearance due to reduced motor activity of the esophagus/stomach related motor/autonomic neuropathy, • Increased sensory thresholds associated with sensory nerve damage of the esophagus, • Acid regurgitation caused by the increased frequency of transient LES relaxations related to neuropathy, CholecystectomyThe reservoir function of the gallbladder disappears after cholecystectomy, and bile flow becomes continuous (20,21). Qualitative changes may appear at the levels of gastrointestinal hormones (22,23). Consequently, alterations in the qualitative bile content and more frequent transient LES relaxation may occur (24). Moreover, it was thought that reflux symptoms in these patients worsen with increased biliary symptoms after cholecystectomy due to a high-fat diet intake and weight gain. Alterations in the motility of the upper gastrointestinal tract and delayed stomach emptying caused by duodenal adhesions may also contribute to GERD (25). There was no significant increase in reflux after cholecystectomy in the limited number of studies based on these data. Uyanıkoğlu et al. (26) used the impedance method and reported increased reflux after surgery and that the pH was <4% higher than that before surgery; however, it was similar to the control group. In another study, Lin et al. (27) compared patients with hernia surgery and cholecystectomy. Reduction in the reflux symptom score was 35% in patients, while it was 39% in controls (p=0.11). Sleeve GastrectomyMechanisms that may induce increased GERD in patients with GERD with sleeve gastrectomy include hypotensive LES (28), blunting of the angle of His (29), decreased gastric compliance (30), delayed gastric em...

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“…Конечно, многие зарубежные авторы оперируют в своих работах существен-но большим материалом. Так, японские исследователи представили данные, полученные при наблюдении 302 больных ССД [15], а в недавно опубликованной статье уче-ных из Алжира изучаемую группу составляли 194 пациента с этим заболеванием [16]. Но эти группы были набраны за многие годы, поэтому данные, полученные нашими колле-гами, не могут считаться одномоментным «срезом» попу-ляции больных ССД.…”

Section: Discussionunclassified

The Real Prevalence of Erosive Esophagitis and Barrett's Esophagus in Systemic Scleroderma: Data From 12-Months Prospective Study

Каратеев¹,

Movsisyan²,

Раденска-Лоповок³

et al. 2012

rsp

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Esophageal Involvement in Scleroderma: Clinical, Endoscopic, and Manometric Features

Cited by 38 publications

References 25 publications

Interstitial Pneumonia With Autoimmune Features: Overview of Proposed Criteria and Recent Cohort Characterization

Interstitial Pneumonia With Autoimmune Features: Overview of Proposed Criteria and Recent Cohort Characterization

Which diseases are risk factors for developing gastroesophageal reflux disease?

The Real Prevalence of Erosive Esophagitis and Barrett's Esophagus in Systemic Scleroderma: Data From 12-Months Prospective Study

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